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Project properties
Title | Molecular Fluorescence Guided Surgery in intracranial meningiomas |
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Keywords | Neurosurgery Meningioma Molecular Fluorescence Guided Surgery |
Researchers |
prof.dr. F.A.E. Kruyt Prof. dr. R.J.M. Groen mw. B.M Dijkstra |
Nature of the research | This project is part of an ongoing clinical trial. The student can gain experience with intra- and post-operative study procedures, labwork and reviewing literature. |
Fields of study | neurosurgery |
Background / introduction |
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Meningiomas are the most frequently occurring intracranial brain tumors in adults. Treatment can be curative with complete surgical resection. To safely increase the extent of resection, improving the intra-operative identification of meningioma tissue is necessary. The approach studied in this project is Molecular Fluorescence Guided Surgery (MFGS). This technique is based on a “red flag” mechanism by fluorescently labelling tumor cells with a tracer. We previously identified Somatostatin Receptor Type 2 (SSTR2) and Vascular Endothelial Growth Factor (VEGF) as candidate biomarkers for MFGS in meningiomas. SSTR2 can be targeted with the novel preclinically evaluated tracer 800CW-TATE, and targeting of VEGF is being done with the already clinically applicable Bevacizumab-IRDye800CW. |
Research question / problem definition |
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Currently, we are investigating the feasibility of using Bevacizumab-IRDye800CW in meningioma patients in a clinical study called the LUMINA trial. |
Workplan |
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The LUMINA trial is open for patient inclusion. The student will help with conducting the clinical trial under supervision of the PI and an MD/PhD student. Depending on the interests of the student, this could mean involvement in the intra-operative study procedures, postoperative tumor analysis at the department of Pathology or reviewing literature. These contributions may lead to co-authorship and potentially to a MD/PhD project. This current project is a collaboration between the departments of Neurosurgery, Medical Oncology, and Pathology & Medical Biology, and the Optical Molecular Imaging Groningen (OMIG) in the UMCG, and the department of Radiology & Nuclear Medicine and Molecular Genetics in the ErasmusMC. |
References |
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Dijkstra, B. M., Jeltema, J. R., Kruijff, S. & Groen, R. J. M. The application of fluorescence techniques in meningioma surgery—a review. Neurosurgical Review 42, 799–809 (2019). Dijkstra, B. M. et al. SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery. Acta Neurochirurgica 160, 1539–1546 (2018). Dijkstra, B. M. et al. Evaluation of Ac-Lys(0)(IRDye800CW)Tyr(3)-octreotate as a novel tracer for SSTR(2)-targeted molecular fluorescence guided surgery in meningioma. Journal of neuro-oncology (2021) doi:10.1007/s11060-021-03739-1. Koller, M. et al. Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers. Nature communications 9, 3739 (2018). |