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Project properties
| Title | 1. PET myocardial perfusion analysis in patients with paroxysmal and persistern atrial fibrillation 2. PET myocardial perfusion analysis in patients with left bundle brach block |
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| Keywords | Atrial fibrillation pet scintigraphy |
| Researchers |
A Elvan, MD PhD F. Daniels M. Mouden |
| Nature of the research | Analaysis of PET data (quantitative analysis of global and regional myocardial perfusion and coronary flow reserve). Analysis of clinical follow up data. |
| Fields of study | nuclear medicine cardiology |
| Background / introduction |
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| Prospective database of >1200 patients referred for ischemia analyis at Isala Heart Centre |
| Research question / problem definition |
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| Clinical outcome and gender differences in perfusionin patients with atrial fibrillation in patients with a "normal" PET scintigraphy. |
| Workplan |
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Collection of clinical data from the hospital database using dedicated software programs like CTcue. Propensity score matching of patients with sinus rhythm and atrial fibrillation. Analysis of data. Report (preferably a scientific paper). |
| References |
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Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T. Eur Heart J. 2007 Sep;28(18):2223-30. doi: 10.1093/eurheartj/ehm246. Epub 2007 Jun 29. PMID: 17604290 Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure: a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography. Byrne C, Hasbak P, Kjær A, Thune JJ, Køber L. Eur Heart J Cardiovasc Imaging. 2019 Feb 1;20(2):233-240. doi: 10.1093/ehjci/jey089. PMID: 29992262 Rapid rest/stress regadenoson ungated perfusion CMR for detection of coronary artery disease in patients with atrial fibrillation. Bieging ET, Haider I, Adluru G, Chang L, Suksaranjit P, Likhite D, Shaaban A, Jensen L, Wilson BD, McGann CJ, DiBella E. Int J Cardiovasc Imaging. 2017 Nov;33(11):1781-1788. doi: 10.1007/s10554-017-1168-1. Epub 2017 May 20. |
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