Project details

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Alterations in ECV in Living Kidney Donors after Nephrectomy

Keywords:
physiology Kidney Donation

Researchers:
Prof. dr. G.J. Navis
Prof. dr. S.P. Berger
Dr. M.H. de Borst
Drs. M. van Londen

Nature of the research:
This longitudinal cohort study is designed to study the alterations in ECV in living kidney donors after nephrectomy

Fields of study:
nephrology

Background / introduction
This research is a part of a larger study program on living kidney donation in the UMCG, embedded in the longitudinal cohort TransplantLines. The UMCG is the only center in the Netherlands which has the license to perform all kind of organ transplantations. The living kidney donation program of the UMCG has steadily increased, with ~100 living donations yearly. In this study we use advanced methods, namely bioelectrical impedance analysis (BIA), to measure several body composition parameters. One of these parameters is extracellular fluid volume ECV, which is associated with blood pressure and sodium regulation in humans. When donating a kidney, donors suddenly lose approximately 50% of their renal mass. Since the kidney is the main regulator of water and sodium homeostasis, we think that donors undergo an acute volume challenge, which may have effects on their body water regulation. This may result in changes in ECV. It is currently unknown if ECV changes after donation and if change in ECV can be linked to GFR, sodium regulation and hypertension post-donation.
Research question / problem definition
1. Does ECV change after nephrectomy?
2. What are the donor determinants of this change?
References
Reese PP, Boudville N, Garg AX. Living kidney donation: Outcomes, ethics, and uncertainty. Lancet, 2015;385(9981):2003–13.
Roos JC, Koomans HA, Dorhout Mees EJ, Delawi IM. Renal sodium handling in normal humans subjected to low, normal, and extremely high sodium supplies. Am J Physiol. 1985; 249: F941-7.
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