Factors of recurrence and progression in meningiomas: DRUM cohort study

Neurosurgery Meningioma Recurrence

Prof. dr. R.J.M. Groen
mw. B.M Dijkstra
Mevrouw Q.C.F. Cordia

Type of project:
Pilot project (year 2 or 3) of Stage Wetenschap / Researchproject

Nature of the research:
This project is part of an ongoing cohort study. The student can gain experience with reviewing literature, data collection and data analysis.

Fields of study:

Background / introduction
Meningiomas are the most common primary intracranial tumours in adults. Treatment is only curative with complete surgical resection, which is currently not possible in all cases. Our knowledge regarding the predisposition for recurrence and progression is limited to the extent of resection (EoR) and WHO grade. This study will analyse meningioma patients operated on in the UMCG between 1993 and 2022. Patient and tumor characteristics will be collected, recorded and analysed.
Research question / problem definition
What factors determine the recurrence and progression of intracranial meningiomas after surgical resection?
The DRUM study is a single-center cohort study of approximatly 2000 intracranial meningioma patients. The student will help with data extraction from the electronic patient system EPIC and with the import into the online data collection tool REDCap. The research question for a tailored pilot project can be designed in consultation with the supervisors.
1. Wiemels , Wrensch M, Claus EB Epidemiology and etiology of meningioma. J Neurooncol. 2010 Sep;99(3):307-14. doi: 10.1007/s11060-010-0386-3.
2. Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology. 2021;23(8):1231–1251.
3. Simpson D. The recurrence of intracranial meningiomas after surgical treatment. Journal of Neurology, Neurosurgery & Psychiatry. 1957;20(1):22–39.
4. Sotoudeh H, Yazdi HR. A review on dural tail sign. World J Radiol. 2010 May 28;2(5):188-92. 10.4329/wjr.v2.i5.188
5. Nassiri F, Wang JZ, Au K, Barnholtz-Sloan J, Jenkinson MD, Drummond K, et al. Consensus core clinical data elements for meningiomas (V2021.1). Neuro-Oncology. 2021;24(5):683–93.
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