Projectdetails

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What are the predictors of advanced (multiple) cutaneous squamous cell carcinoma in organ transplant recipients?

Keywords:
Skin cancer organ transplant

Researchers:
prof. dr. S.J.L. Bakker
dr. E. Racz

Nature of the research:
Retrospective cohort study

Fields of study:
dermatology epidemiology oncology

Background / introduction
Organ transplant recipients have a minimal 65x higher risk to develop cutaneous squamous cell carcinoma. These tumors generally have a good prognosis and are easy to remove with little discomfort for the patients. Some patients, however, develop multiple and high risk tumors which can on the long term become a serious burden, and might lead by the development of distant metastases to the death of the patients.
Research question / problem definition
What are the predictors of the development of multiple/high risk cutaneous squamous cell carcinoma’s in organ transplant recipients?
Workplan
1. Extract additional data from PALGA to obtain complete information on skin cancer development amongst Transplantlines participants.
2. Construct database with skin cancer data.
3. Form hypotheses on possible relevant predictors (dialysis duration, data on transplantation, donor match, comorbidity, medication, lifestyle, frailty)
4. Check hypothesis by performing Cox regression analysis
References
Garrett et al. Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013. J Am Acad Dermatol. 2016; 75(1):106-12.
Tokez et al. Cumulative incidence and disease-specific survival of metastatic cutaneous squamous cell carcinoma: A nationwide cancer registry study. J Am Acad Dermatol. 2021 Oct 13; S0190-9622(21)02644-X. doi: 10.1016/j.jaad.2021.09.067

Lanz et al. Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients. JAMA Dermatol. 2019 Jan 1; 155(1):66-71.
Frie et al. Health-Related Quality of Life in Solid Organ Transplant Recipients With vs Without Keratinocyte Carcinoma. JAMA Dermatol. 2020 Apr 1;156(4):464-466.
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