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allergology (12)
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(medical)genetics (5)
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aanhoudende lichamelijke klachten (ALK) (1)
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cancer cell apoptosis (1)
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cell cycle (1)
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cell-cell junction (1)
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children (14)
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chromosomal aberration (1)
Chromosomal instability (3)
chromosome (1)
chronic depression (1)
chronic disease (4)
Chronic Kidney Disease (5)
chronic lung allograft dysfunction (1)
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chronic ventilatory support (1)
Circadian rhythmicity (1)
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clinical decision-making (1)
clinical diagnostics (3)
clinical epidemiology (2)
clinical genetics (1)
Clinical retrospective patient outcome study (1)
co-morbidity (2)
coagulation (1)
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cochlear implants (1)
Cognition (4)
cognition and outcome (2)
cognitive decline (1)
cognitive function (1)
cognitive impairment (1)
colonic stenting (1)
colonisation (1)
colonoscopy (2)
colorectal (1)
colorectal cancer (2)
colorectal livermetastases (1)
colorectal surgery (2)
Community Mental Health (1)
comorbidity (1)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (2)
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complement (3)
compliance (3)
complications (4)
Comprehensice geriatric assessment (1)
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computed tomography (CT) (1)
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congenital heart disease (3)
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coronary artery bypass grafting (1)
Coronary Artery Disease (1)
coronary calcium score (2)
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COVID-19 (4)
craniopharyngioma (2)
Critically ill children (3)
Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
crosscultural (1)
crosscultural comparison (1)
crystallography (4)
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CVRM (1)
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database (3)
database registry (2)
Deep brain stimulation (DBS) (5)
Deep learning (1)
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dementia (6)
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depression (5)
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dermatology (2)
Descriptive and retrospective study with clinical results (1)
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Developmental Dysplasia of the Hip (DDH) (2)
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elderly (12)
elderly cancer patients (1)
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Endothelial Cell (2)
endothelial cells (2)
endoveneuze laser behandeling (1)
energy metabolism (3)
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eNose (3)
epidemiology (10)
epidermolysis bullosa (2)
epigenetics (5)
epinephrine auto-injector (1)
epithelial cells (1)
epithelial disorders (1)
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esophagus surgery (2)
Essential tremor (2)
ethical issues (1)
ethics (3)
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EVLT (1)
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exercise testing (2)
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exome sequencing (1)
extracellular matrix (1)
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factor VIII (1)
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fluid administration, hemodynamic monitoring (2)
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frailty (5)
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Function Endoscopic Sinus Surgery (1)
functional genetics (2)
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gene enrichment (1)
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genetics (8)
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hand function test (4)
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health-related quality of life (2)
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hematology, cancer, critical care, outcome (2)
hematopoiesis (6)
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hip and knee prothesis (3)
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HIV (3)
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Home mechanical ventilation (3)
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hospital Deventer (14)
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human genetics (1)
human hematopoietic stem cells (3)
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hydrogen sulfide (2)
hyperbare zuurstoftherapie (2)
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imaging (10)
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immune system (1)
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immunohistochemistry (1)
immunology (8)
immunotherapy (7)
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ischemia/reperfusion injury (2)
ischemic stroke (2)
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kidney transplantation (6)
kidneydonor (1)
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knockout mouse (1)
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kwaliteit van zorg (3)
laboratory animals (5)
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levenseinde (2)
LifeLines (2)
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liver diseases (1)
liver metastases (1)
liver resection (2)
liver surgery (1)
liver transplantation (8)
local recurrence (2)
locally advanced rectal caner (1)
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Long non-coding RNAs (1)
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lung mechanics (2)
lung nodules (1)
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molecular biology (3)
molecular chaperones (2)
Molecular Fluorescence Guided Surgery (1)
molecular genetics (1)
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molecular microbiology (1)
molecular typing (1)
monocytes (2)
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Mouse models (4)
movement disorders (2)
MRI (5)
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MRI / magnetic resonance imaging (1)
MRS (1)
mucosal melanoma (1)
multi-morbidity (1)
Multi-organ failure (1)
Multi-phase CT (1)
multidisciplinairy regional team meetings (1)
multidrug resistance (1)
Multimorbidity (5)
multiple myeloma (1)
multiple sclerosis (4)
multitrauma (1)
Musculoskeletal pain (1)
Music (2)
music intervention (1)
music therapy (4)
mutations (1)
myelin (1)
myocardial infarction (1)
myocardial perfusion (2)
myoclonus (1)
myoclonus dystonia (1)
naadlekkage (1)
NaF PET/CT (1)
nasality (1)
NASH (2)
nasopharyngeal carcinoma (1)
Near-Infrared Spectroscopy (1)
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necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
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neoadjuvant chemoradiotherapy (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
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neonatale icterus (1)
neonates (2)
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neuroblastoma (1)
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neurodegenerative diseases (1)
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neuroendocrine tumor (1)
Neuroimaging (6)
neuroinflammation (1)
neurological development (1)
neurology (1)
neuromuscular blockade (1)
neuropathic pain (1)
neuropathy (2)
neuropsychiatric symptoms (1)
Neurosurgery (4)
neutropenia (1)
nier (1)
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non-alcoholic fatty liver disease (1)
non-coding RNA (1)
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Non-motor symptoms (3)
Non-small cell lung cancer (2)
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novel cancer drug (1)
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nursing home (1)
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nutrient addiction (1)
nutrition (8)
nutritional status (1)
nutritition (1)
obesitas (3)
obesity (6)
observational scale (1)
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Older adults (1)
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oncological epidemiology (1)
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oncology (10)
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ongeplande heropname (1)
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Organ failure (1)
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orthopedics (5)
orthopedie (1)
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outcome (4)
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Outcomes (2)
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Overactieve blaas (2)
overweight (2)
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Improving personalized treatment in oncology (IPTO). Effects of integrated oncological decision making
Keywords: oncology
shared decision making
personalized treatment
Researchers:
dr. B.L. van Leeuwen
drs. H. van der Wal- Huisman
Vera Hanewinkel
Type of project: Stage Wetenschap / Research project
Nature of the research:
Clinical trial
Fields of study:
surgery
Background / introduction
Currently, oncological treatment plans and decision-making are predominantly based on medical information following strict guidelines. Based on the conviction that oncological treatment plans can and should be more tailored to the individual, an outline for the Integrated Oncological Decision-making Model (IODM) has been developed. The IODM aims to individualize treatment decisions through the integration of patient’s health status and goals/preferences in formulating treatment decisions.
Research question / problem definition
The primary objective of the current study is to evaluate the effect of the IODM on personalized decision-making. We hypothesize that with the use of the IODM, decisions will
more often differ from the MDT recommendation based on guidelines/expertise, and that use
of the IODM intervention will lead to more personalized decisions for Dutch cancer patients.
Workplan
This project integrates the IODM in gynecologic oncology and oncologic urology in two hospitals. Patients in the participating tumor boards included. Both quantitative data (clinical data, patient characteristics, patient reported outcomes) and qualitative data (audio tapes) will be collected during the patient's care trajectory. Analyzes will be performed on both cohorts in order to evaluate the effect of the IODM.
References
Kader Passende zorg, Zorginstituut Nederland. 28-06-2022
Festen S, Kok M, Hopstaken JS, et al. How to incorporate geriatric assessment in clinical decision making for older patients with cancer. An implementation study. J Geriatr Oncol. 2019;10(6):951-
959. doi:10.1016/j.jgo.2019.04.006
Festen S, van der Wal-Huisman H, van der Leest AHD, et al. The effect of treatment modifications by
an onco-geriatric MDT on one-year mortality, days spent at home and postoperative complications. J Geriatr Oncol. 2021;12(5):779-785. doi:10.1016/j.jgo.2020.12.003