Project details


Cardiopulmonary bypass during cardiac surgery and the obesity epidemic.

obesity cardiac surgery cardiopulmonary bypass

M. Dries
R.F. Hoffmann
G. Jansma

Type of project:
TTT project (year 1), Pilot project (year 2 or 3) of Stage Wetenschap / Researchproject

Nature of the research:
Retrospective study using observational data of cardiopulmonary bypass during cardiac surgery.

Fields of study:
cardiology and thoracic surgery medical physiology

Background / introduction
Cardiopulmonary bypass (CPB) flow rate required for optimal perfusion during cardiac surgery is calculated using body surface area (BSA). However, obese patients with higher BSA may require an altered flow rate. In obese patients BSA reflects partly body fat that is hypothesized to require less perfusion than internal (organ)tissue. Current CPB flow rate calculations are inconsiderate of excessive body fat. It is likely that this leads to excessive CPB flow rate. It is yet unknown how obese patients are affected by current CPB flow calculations. Albeit that the current obesity epidemic demands to investigate the optimal cardiopulmonary bypass flow rate in obese patients.
Research question / problem definition
We aim to investigate cardiopulmonary bypass flow and postoperative morbidity and mortality in obese patients undergoing cardiac surgery.
- (Completion of) data colletion
- Perform analyses
- co-authorship on publication of data
Murphy et al. Optimal perfusion During Cardiopulmonary Bypass: An Evidence-Based Approach. Anesthesia & Analgesia 108(5):p 1394-1417, May 2009. | DOI: 10.1213/ane.0b013e3181875e2e

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