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allergology (12)
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cardiac differentiation (1)
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cell cycle (1)
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children (12)
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clinical epidemiology (2)
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Clinical retrospective patient outcome study (1)
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coagulation (1)
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cochlear implants (1)
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cognition and outcome (2)
cognitive function (1)
cognitive impairment (1)
colonic stenting (1)
colonisation (1)
colonoscopy (2)
colorectal (1)
colorectal cancer (2)
colorectal livermetastases (1)
colorectal surgery (2)
Community Mental Health (1)
comorbidity (1)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (2)
competency development (1)
complement (3)
compliance (3)
complications (4)
Comprehensice geriatric assessment (1)
Comprehensive geriatric assessment (1)
Congenital anomalies (1)
congenital heart disease (3)
connective tissue disease (1)
continue glucose monitoring (3)
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COPD (16)
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coronary artery bypass grafting (1)
Coronary Artery Disease (1)
coronary calcium score (2)
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Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
crosscultural (1)
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crystallography (4)
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data management (1)
database (3)
database registry (2)
Deep brain stimulation (DBS) (3)
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delirium (1)
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dementia (6)
dementie / cognitie (1)
depressie (1)
depression (5)
Depression, (1)
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dermatology (2)
Descriptive and retrospective study with clinical results (1)
development (1)
Developmental coordination disorder (1)
developmental disorder (1)
developmental disorders (1)
Developmental Dysplasia of the Hip (DDH) (2)
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diabetes (9)
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diffuse Large B-cell lymphoma (DLBCL) (1)
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endothelial cells (2)
endoveneuze laser behandeling (1)
energy metabolism (3)
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epidemiology (10)
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epinephrine auto-injector (1)
epithelial cells (1)
epithelial disorders (1)
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esophageal carcinoma (1)
esophagus surgery (2)
Essential tremor (1)
ethical issues (1)
ethics (3)
evidence-based medicine (2)
EVLT (1)
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exercise testing (2)
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exome sequencing (1)
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First Episode Psychosis (1)
first trimester anomaly scan (1)
first trimester ultrasound (1)
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fluid administration, hemodynamic monitoring (2)
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functional genetics (2)
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Gender (1)
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gene enrichment (1)
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general practice (4)
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genetic testing (1)
genetics (8)
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hematology, cancer, critical care, outcome (2)
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hospital Deventer (14)
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imaging (8)
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laboratory animals (5)
laparoscopy (2)
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late effects of treatment (1)
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liver diseases (1)
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liver transplantation (7)
local recurrence (2)
locally advanced rectal caner (1)
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Long non-coding RNAs (1)
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lung (1)
lung cancer (3)
Lung function (2)
lung mechanics (2)
lung nodules (1)
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multidisciplinairy regional team meetings (1)
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Multimorbidity (5)
multiple myeloma (1)
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myocardial perfusion (2)
myoclonus (1)
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NaF PET/CT (1)
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NASH (2)
nasopharyngeal carcinoma (1)
Near-Infrared Spectroscopy (1)
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necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
Neglected Tropical Diseases (1)
neoadjuvant chemoradiotherapy (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
Neonatal outcome (1)
neonates (2)
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neuroblastoma (1)
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neurodegenerative diseases (1)
neurodevelopmental outcome (1)
neuroendocrine tumor (1)
Neuroimaging (4)
neuroinflammation (1)
neurological development (1)
neurology (1)
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neuropathy (2)
neuropsychiatric symptoms (1)
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neutropenia (1)
nier (1)
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novel cancer drug (1)
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nutrient addiction (1)
nutrition (7)
nutritional status (1)
nutritition (1)
obesitas (1)
obesity (6)
observational scale (1)
obstetrics (1)
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oesofaguscarcinoom (1)
oesophagectomy (1)
Older adults (1)
oligodendrocytes (2)
Oncologic emergencies (1)
oncological epidemiology (2)
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oncology (8)
onderwijskunde (1)
ongeplande heropname (1)
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ontwikkelen (reken)model (1)
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opthalmologic problems (1)
Organ failure (1)
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ototoxicity (1)
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outcome (3)
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Outcome measurement (4)
Outcomes (2)
ovarian cancer (6)
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overweight (2)
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Adverse side-effects of antidepressants: are all patients at the same risk?
Keywords: antidepressants
Personalized medicine
adverse side effects
Researchers:
Prof. dr. M.Y. Berger
dr. H. Burger
prof. dr. R.A. Schoevers
S.M. van Belkum
prof.dr. ND Scherpbier
Type of project: Stage Wetenschap / Research project
Nature of the research:
Prospective cohort study
Fields of study:
GP medicine
psychiatry
Background / introduction
Over 1 million Dutch people currently get an antidepressant prescribed, with depression as the main indication. Although the effectiveness of antidepressant medication (AD) in the treatment of depression is well-established, long-term AD use also results in several adverse side effects. They include sexual dysfunction, emotional flattening, dry mouth, headache, weight gain, increased autonomic tone and metabolic dysregulation. These adverse side effects are not only disturbing to the patient, they are also associated with treatment failure by discontinuation of AD, including Selective Serotonin Reuptake Inhibitors (SSRI’s).
Therefore, it is key to know which type of patients are at risk of adverse side effects in particular, as to be able to provide optimally personalized treatment for depression. Yet, the determinants of adverse side effects of AD remain poorly understood. In this project we will investigate in a large cohort of SSRI users (N ~ 600) who participated in the Optimal, PERsonalized Antidepressant (OPERA) study whether there are subgroups of patients with an increased risk of adverse side effects.
Research question / problem definition
What are demographic and clinical determinants of an increased risk of adverse side effects among long term users of SSRI’s?
Workplan
1. Understand the study OPERA study on the course of depression in a naturalistic cohort of adults with depression who started with antidepressants (citalopram or sertraline) at most two years before inclusion and perform some exploratory data analyses.
2. Formulate hypotheses in line with the research question and based on literature
3. Define determinants and outcomes and create a database for the analyses
4. Perform the analyses with help of a senior epidemiologist
5. Write the report
References
Bet PM, Hugtenburg JG, Penninx BW, Hoogendijk WJ. Side effects of antidepressants during long-term use in a naturalistic setting. Eur Neuropsychopharmacol. 2013;23(11):1443-51.
Reichenpfader U, et al. Sexual dysfunction associated with second-generation antidepressants in patients with major depressive disorder: results from a systematic review with network meta-analysis. Drug Saf. 2014;37(1):19-31.