Project details


Medical comorbidity in patients with bipolar disorder

bipolar disorder metabolic syndrome medical comorbidity

M. Chrispijn

Type of project:
Stage Wetenschap / Researchproject

Nature of the research:
Retrospective cohort research

Fields of study:
general internal medicine psychiatry diabetes

Background / introduction
Patients with bipolar disorder have a shorter life expectancy than healthy controls. This largely due to cardiovascular disease, which seems to be more prevalent in this patient group.
Research question / problem definition
What is the prevalence of metabolic syndrome in patients with bipolair disorder in comparison with healthy controls? Can predictive factors be identified?
Writing a research and analysis plan for obtaining data from a large Dutch database. Analysing data together with researchers connected to the database. If interested you can help publishing the article.
1. Erlangsen A, Andersen PK, Toender A, Laursen TM, Nordentoft M, Canudas-Romo V. Cause-specific life-years lost in people with mental disorders: a nationwide, register-based cohort study. Lancet Psychiatry. 2017;4:937–45.
2. Hjorthøj C, Stürup AE, McGrath JJ, Nordentoft M. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. The lancet Psychiatry [Internet]. 2017 [cited 2019 Nov 17];4(4):295–301. Available from:
3. Kessing LV, Vradi E, Andersen PK. Life expectancy in bipolar disorder. Bipolar Disord. 2015 Aug 1;17(5):543–8.
4. Forty L, Ulanova A, Jones L, Jones I, Gordon-Smith K, Fraser C, et al. Comorbid medical illness in bipolar disorder. Br J Psychiatry [Internet]. 2014 Dec [cited 2019 Nov 16];205(6):465–72. Available from:
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