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Make a choice prf. dr. B. van Munster S.G. Brederoo

Project properties

Title	Automatic speech analysis for early detection of delirium
Keywords	delirium
Researchers	prf. dr. B. van Munster S.G. Brederoo
Nature of the research	Prospective cohort study
Fields of study	health psychology geriatrics

Background / introduction

Older patients, especially frail older patients are at risk for postoperative delirium. In daily practice delirium is frequently missed leading to negative outcomes like complications and long term cognitive impairment. Often prodromal symptoms precede the full-blown syndrome, providing an ideal opportunity to optimize non-pharmacological preventive interventions for delirium. Diagnosis of delirium is based on psychiatric examination using among others impressions of speech. Automatically extracted speech parameters have been shown to accurately discriminate patients with a schizophrenia-spectrum disorder from healthy controls and might be able to classify delirium as well.

Research question / problem definition
1. Are automatically extracted speech parameters able to discriminate delirious from non-delirious patient? 2. Are automatically extracted speech parameters able to predict delirium?

Workplan

We will include 100 patients aged >70 years after a planned surgical procedure. Inclusion criterium is an increased risk for delirium based on the VMS criteria for delirium and the Dutch language as mother tongue. Exclusion criteria: no informed consent, speech disorder (e.g. stutter), uncorrected hearing impairment. Patients will be monitored daily by the delirium observations scale (DOS). In case of DOS>3 a physician will diagnose delirium according to the DSM5 criteria. Speech will be recorded daily with a structured interview of 5 minutes. Acoustic parameters will be extracted with OpenSMILE, including a range of acoustic features such as speech quality and pauses. Speech parameters will be fed into a random forest algorithm with leave-ten-out cross-validation to assess their value for a delirium diagnosis. You will write a report on the results, which can be optionally submitted for publication in a scientific journal.