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allergology (9)
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epidemiology and statistics (20)
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haematology (25)
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health sciences (22)
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intensive care (28)
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laboratory medicine (8)
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medical education (6)
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microbiology (23)
molecular biology (34)
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movement sciences (15)
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obstetrics (4)
oncology (77)
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Patient Related Research (10)
pediatrics (83)
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Stamcelbiologie (3)
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surgery (94)
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urology (10)
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(Epi)genetic epidemiology (1)
(medical)genetics (5)
5jaars overleving (1)
:psychosocial and lifestyle determinants (4)
aanhoudende lichamelijke klachten (ALK) (1)
abdomen (1)
access to medicine (1)
ACE-inhibitor (1)
Acetabular fracture (1)
Acetylcholine (1)
Achilles tendinopathy (1)
Achilles tendinopatie (1)
ACS-NSQIP surgical risk calculator (1)
activated clotting time (1)
Acute flaccid myelitis (1)
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Acute Myeloid Leukemia (1)
acute myocardial infarction (2)
adpkd (3)
Advanced cell culture (1)
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adverse side effects (1)
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ageing (4)
ageing lungs (1)
Ageing, Nuclear Envelope, Nuclear Pore Complex (1)
aging (1)
airway epithelium (1)
Alcohol (3)
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Allergic asthma (1)
Allergologie (1)
Allergy (1)
allogene stam cel transplantatie (2)
Allogeneic stem cell transplantation (1)
Amalgaam (2)
ambulance (1)
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ANCA associated vasculitis (1)
anesthesia (5)
Anesthesiologie (1)
anesthesiology (2)
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Animal research (2)
ankylosing spondylitis (2)
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antibiotics (3)
anticoagulants (2)
antidepressants (4)
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anxiety (1)
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aortic stenosis (1)
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Appendicitis (2)
arrhythmia (1)
arterioveneuze fistel, dialyse shunt (1)
Artificial Intelligence (3)
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asthma (7)
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astma (1)
asylum seekers (1)
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atherosclerosis (3)
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autoimmune blistering diseases (1)
autoimmune disease (6)
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Autophagy (2)
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beta cell destruction (1)
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biofilm (1)
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brain (3)
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brain tumour (2)
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Breast augmentation mammoplasty (2)
breast cancer (5)
breast conserving surgery (1)
Breast implants (1)
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bronchial epithelium (1)
built environment (1)
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Calorie restriction (1)
Calprotectin (2)
cancer (30)
cancer cell apoptosis (1)
Cancer cell metabolism (1)
cancer cells (1)
cancer patients (2)
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Cardiac Amyloidosis (2)
cardiac differentiation (1)
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cardiac output (1)
cardiac surgery (1)
cardio-pulmonary toxicity (1)
cardiogenetics (2)
cardiology (10)
cardiometabolic health (1)
cardiopulmonary bypass (1)
Cardiovasculaire effecten (1)
cardiovascular (4)
cardiovascular disease (6)
cardiovascular risk (1)
cardiovascular risk management (1)
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caries (1)
carriers (1)
cartilage (2)
Catheterization lab (1)
celiac disease (4)
cell biology (1)
cell cycle (2)
cell death (3)
cell saver (1)
cellbiology (1)
cellular interactions (1)
Central Sensitization (nociplasticity) (1)
cerebral palsy (1)
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Cervical spine (2)
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child (2)
Child development (1)
child outcome (2)
childbirth (1)
children (9)
ChIP assay (1)
cholangiocyte (1)
cholestasis (1)
cholesterol fluxes (1)
chromosome (1)
chronic depression (2)
chronic disease (2)
Chronic Kidney Disease (5)
chronic lung allograft dysfunction (1)
Chronic rhinosinusitis (1)
chronic ventilatory support (1)
Chronische pijn (2)
Circadian rhythmicity (1)
cirrhosis (2)
Clinical decision making (1)
clinical decision-making (1)
clinical diagnostics (4)
clinical epidemiology (1)
clinical genetics (1)
Clinical retrospective patient outcome study (1)
Clinical Severity Score (1)
co-morbidity (1)
coagulation (1)
coating (1)
coccygodynie (1)
cochlear implant users (1)
Cognition (1)
cognition and outcome (2)
cognitive decline (1)
cognitive function (3)
cognitive impairment (1)
cognitive testing (1)
collect clinical information (1)
Colon carcinoma (1)
colonisation (1)
colorectal cancer (2)
colorectal cancer, CEA value, CT-scan, follow up (1)
colorectal surgery (3)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (1)
competency development (1)
complement (3)
complex congenital heart disease (1)
compliance (1)
complications (4)
Comprehensice geriatric assessment (1)
computed tomography (CT) (3)
Congenital anomalies (1)
congenital heart disease (3)
connective tissue disease (1)
Constipation (1)
continue glucose monitoring (1)
contraction (1)
contrastmiddel (1)
COPD (14)
Coronair angiografie (1)
coronary arteries (1)
coronary artery bypass grafting (1)
Coronary Artery Disease (3)
cosmetic outcome (1)
costs (3)
cough (1)
COVID-19 (6)
craniopharyngioma (2)
Craniotomy (1)
Critically ill children (3)
Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
CT (1)
CT imaging (2)
CT-scan (1)
cystic fibrosis (4)
cytokines (1)
Damage (1)
database (3)
database registry (1)
Deep brain stimulation (DBS) (6)
deletion (2)
delirium (1)
delivery agent (1)
dementia (3)
dental erosion (1)
dental hygiene (1)
dentist (1)
Deprescribing (1)
depression (4)
Depression, (2)
Depression, translational neuroscience (1)
dermatology (3)
Descriptive and retrospective study with clinical results (1)
development (3)
Developmental coordination disorder (1)
developmental disorder (1)
developmental disorders (1)
Developmental Dysplasia of the Hip (DDH) (2)
developmental psychopathology (1)
Dexamethasone (1)
diabetes (3)
Diabetes mellitus (4)
diabetis (1)
diagnostic importance (1)
diagnostic test (1)
diagnostics (3)
dialysis (3)
Diaphragm paralysis (1)
Diet (2)
dilated cardiomyopathy (1)
disease activity (1)
disease models (1)
Disease modifying therapy (1)
DNA (1)
DNA damage (1)
DNA damage response (1)
DNA methylation signatures (1)
donor (1)
Drosophila (2)
drug delivery (1)
Drug Interactions (1)
dry eye (2)
duplication (1)
Dupuytren's disease (1)
Dupuytren's disease (1)
Dystonia (6)
e-health (5)
early detection (1)
early life experiences (1)
Early Onset Ataxia (2)
eating disorders (1)
echo duplex, diagnotische waarde (1)
echocardiography (2)
eco-anxiety (1)
Education (2)
EEG-EMG (1)
effects (1)
Ehealth (10)
Elder (1)
elderly (6)
elderly cancer patients (1)
elderly patients (2)
electroconvulsive therapy (1)
Electronic Nose (1)
EMG (2)
EMG-analysis (1)
emphysema (1)
EMSA (1)
enamel (1)
end-expiratory lung volume (1)
endocrine disrupting chemicals (1)
endocrine therapy (1)
endocrinology (1)
endometriosis (1)
Endophenotypes (1)
Endothelial Cell (2)
endothelial cells (1)
endoveneuze laser behandeling (1)
energy metabolism (3)
engineering (1)
enkelletsel (1)
eNose (1)
epidemiology (9)
epidermolysis bullosa (2)
epigenetics (4)
epithelial cells (1)
epithelial disorders (1)
ercp (1)
errors (1)
erythropoietin (1)
Esophageal cancer (1)
esophageal carcinoma (2)
Esophageal pressure (1)
esophagus surgery (2)
Essential tremor (3)
ESWL (2)
ethics (1)
evidence-based medicine (1)
EVLT (1)
Ex vivo lung perfussion (1)
exercise testing (1)
exercise therapy (1)
Exercise training (1)
Exergames (1)
exome sequencing (3)
Faecalibacterium prausnitzii (1)
familial hypercholesterolemia (1)
Family history (2)
Farmacologie (1)
farmacology (1)
fatigue (4)
fatty acids (1)
fatty liver disease (1)
FDG PET/CT (2)
fecal incontinence (1)
fertility (1)
fetal gender (1)
fibrosis (3)
filling (2)
First Episode Psychosis (2)
first trimester anomaly scan (1)
first trimester ultrasound (1)
fitness (1)
fluid administration, hemodynamic monitoring (1)
fluid management (1)
Fluorescence imaging (1)
fMRI (1)
fNIRS-monitoring (1)
foot ulcers (1)
frailty (3)
Frailty screening (2)
Function Endoscopic Sinus Surgery (1)
functional genetics (2)
functional somatic symptoms (1)
Functional stroke mimic (1)
functionele symptomen (1)
Fungal Infections (1)
fysiotherapie (1)
gait (1)
galectin-3 (1)
Galgangatresie (1)
game (1)
gangliosides (1)
GBA1-gene (1)
GECKO (1)
Gender (1)
gene enrichment (1)
gene expression (1)
gene regulation (1)
general movements (1)
general practice (3)
general practitioner (1)
genetic diseases (1)
Genetic sequencing (1)
genetic testing (1)
genetics (5)
genome analysis (1)
genomic instability (1)
genotype-phenotype correlation (1)
geriatric oncology (1)
geriatrics (2)
glaucoma (2)
Glioblastoma (1)
Gliomas (1)
global child health (1)
global health (2)
Glomerular filtration rate (1)
Glucocorticoids (1)
glucose homeostasis (1)
growth hormone deficiency (1)
Guidelines (2)
Guillain-Barré syndrome (1)
Gunanine Nucleotide Exchange Factor (1)
Gut Microbiota Composition (2)
gut-liver acis (1)
haemophilia (2)
hand (1)
Head and neck cancer (5)
Health care professionals (1)
Health care utilization (1)
health economics (3)
Health indicators (1)
Health literacy (1)
Health Related Quality of Life (1)
health-related quality of life (4)
healthcare education (1)
healthcare transformation (1)
hearing impairment (1)
hearing rehabilitation (1)
heart (14)
heart failure (7)
Heart rate variability (1)
heart transplantation (1)
heart valve replacement (1)
heat shock proteins (1)
Heel prick Screening (1)
hematology, cancer, critical care, outcome (3)
hematopoiesis (5)
hemodynamic monitoring (2)
hemodynamics (1)
hemostasis (2)
heparin induced thrombocytopenia (1)
hepatitis (2)
hepatocellular carcinoma (1)
hereditary cancer (1)
hereditary kidney disease (1)
HFOV (2)
Hibernation (4)
Hidradenitis suppurativa (1)
hip (1)
hip and knee prothesis (2)
Hip artroplasty (1)
Historical controls (1)
HIV (3)
Hodgkin lymphoma (2)
Home mechanical ventilation (3)
Honours education (1)
hormone receptors (1)
HPB surgery (1)
huisarts (1)
Huisartsgeneeskunde (1)
human genetics (1)
human hematopoietic stem cells (3)
Humeral Fractures (1)
hydrochlorothiazide (1)
hydrogen sulfide (1)
hymenoptera venom allergy (1)
hyperglycaemia (1)
Hyperkinetic movement disorders (2)
Hypertensie (1)
hypoglycemia (1)
hypophospatemic rickets (1)
hypoplastic left heart syndrome (1)
hypotension (1)
IBD (4)
IGF-1 (1)
image biomarker (2)
imaging (12)
imaging, biomarkers (1)
Immune checkpoint inhibitors (3)
immune response (1)
immune suppression (1)
Immune-related adverse events (1)
immunity (1)
immunology (10)
immunosuppression (1)
immunotherapy (4)
impact (1)
implant infection (2)
in vitro (1)
in vitro fertilization (1)
Inborn Error of Metabolism (1)
incidence (1)
incontinence (2)
individualised treatment (1)
infant (2)
infant assessment (2)
infant development (3)
Infant Stool Colour Card (1)
infection (3)
Infection and inflammation (1)
Infectious diseases (1)
Infective Endocarditis (1)
inflammation (5)
Inflammatory bowel disease (3)
Inflammatory rheumatic disease (3)
Informatie-uitwisseling (1)
Information technology (1)
Inguinal Hernia Surgery (1)
innovatie van zorg (2)
insulin (1)
insulitis (1)
Integrative care (1)
intellectual disability (1)
Intensive care (1)
interactie (1)
interprofessional education (1)
Interviews (1)
Interviewstudie (1)
intestinal disease (2)
intestinal disorder (1)
intestinal integrity (1)
intestinal transplantation (2)
Intestinal wall permeability (1)
intestine (1)
Intracraniele druk (1)
Intraoperative neurophysiology (1)
IONM (1)
iPSC (1)
iron deficiency (2)
ischemia (3)
ischemia-reperfusion injury (1)
ischemia/reperfusion injury (2)
ischemic stroke (2)
Isolation (1)
isotopes (1)
IVF (3)
jaundice (2)
joint (2)
Ki67 proliferation index (1)
kidney (6)
kidney disease (5)
Kidney Donation (3)
kidney transplantation (13)
kidneydonor (1)
Kindergeneeskunde (1)
kinetic modeling (1)
Klinische onderzoeksstage (1)
knockout mouse (1)
kwaliteit van leven (2)
kwaliteit van zorg (1)
laboratory animals (10)
language development (1)
language screening (1)
laparoscopy (1)
laryngectomy (3)
late effects of treatment (1)
Leadership (1)
learning curve sonologist (1)
learning organization (1)
leefstijl (1)
leukemia (3)
leukemic stem cells (2)
LifeLines (2)
lifestyle (4)
liposomes (1)
lipotoxicity (1)
liver (3)
liver cancer (1)
liver disease (5)
liver diseases (1)
liver failure (1)
liver fibrosis (1)
liver metastases (1)
liver resection (1)
liver transplantation (10)
livercirrhosis (1)
locally advanced rectal caner (1)
locomotion (1)
long-term survival (1)
longitudinal (1)
lumg transplantation (1)
lung (4)
lung cancer (5)
Lung function (1)
lung mechanics (2)
lung nodules (2)
lung recruitment (1)
lung transplantation (5)
lymphoma (2)
lynch syndrome (1)
machine learning (Matlab/Rstudio) (1)
machine perfusion (2)
major depressive disorder (1)
mass spectrometry (2)
mast cells (1)
mastocytosis (3)
measurement tool (1)
mechanical ventilation (10)
medical comorbidity (1)
medical device (4)
medical education (2)
medical imaging (8)
medically unexplained symptoms (2)
medication (3)
Medication reviews (1)
medication safety (1)
medication treatment (1)
medicine (1)
melanoma (5)
Meningioma (2)
meno-pauze (1)
mental retardation (1)
metabolic diseases (5)
Metabolic signaling (1)
metabolic syndrome (3)
metabolism (3)
metabolites (1)
metabool syndroom (3)
metformin (1)
method development (2)
microbiome (1)
microbiota (3)
microcephaly (1)
Microglia (1)
microRNA (2)
Minimally invasive parathyroidectomy (1)
mitochondria (1)
MitraClip (1)
Mobile electrocardiogram devices (1)
Mobility (1)
molecular biology (2)
molecular chaperones (1)
Molecular Fluorescence Guided Surgery (1)
molecular mechanisms (1)
molecular microbiology (1)
Molecular tumour board (1)
molecular typing (1)
Monoclonal antibodies (1)
monocytes (1)
mood disorders (1)
Motor development (2)
Mouse models (1)
movement disorders (3)
MRI (8)
MRI / CT (1)
MRI / magnetic resonance imaging (3)
MRI brain (1)
MRS (1)
mucosal melanoma (1)
mucus clearance (1)
multi-morbidity (1)
Multi-organ failure (1)
Multi-phase CT (1)
multidrug resistance (1)
Multimorbidity (3)
multiple myeloma (2)
multiple sclerosis (4)
Musculoskeletal pain (1)
Music (1)
music intervention (1)
music therapy (4)
mutations (2)
myelin (1)
myocardial infarction (2)
myoclonus (1)
myoclonus dystonia (1)
NASH (1)
nasopharyngeal carcinoma (1)
Necrotische Enterocolitis (1)
necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
Neglected Tropical Diseases (1)
neoadjuvant chemoradiotherapy (1)
neonatal hypoglycemia (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
Neonatal outcome (1)
neonatale icterus (1)
neonates (2)
neonatology (1)
nephrology (2)
neuro-endocrine tumors (1)
neurobiology (1)
neurocognition (1)
neurodegeneration (4)
neurodegenerative diseases (3)
neurodevelopmental impairment (1)
neurodevelopmental outcome (1)
neuroendocrine tumor (1)
Neuroimaging (5)
neuroinflammation (1)
neurological development (1)
neurology (1)
neuromuscular blockade (1)
neuropathic pain (1)
neuropathy (1)
neuropsychiatric symptoms (1)
Neurosurgery (4)
neurotransmitters (1)
neutropenia (1)
new genes (1)
nier (1)
non-Hodgkin's disease (1)
Non-invasive ventilation (2)
Non-motor symptoms (2)
Noordzeeziekte (1)
Nuclear Medicine (1)
nuclear receptors (1)
nursing home (1)
Nursing home residentss (1)
nutrient addiction (1)
nutrition (8)
obesity (6)
Occupational exposures (1)
Occupational health (1)
Older adults (1)
oligodendrocytes (1)
oncological epidemiology (1)
oncology (6)
oncoplastic surgery (1)
ongeplande heropname (1)
online wearables (1)
opthalmologic problems (1)
organ preservation (3)
organ transplant (1)
organ transplantation (2)
orthopedics (3)
osteomyelitis (1)
otolaryngology (1)
Ouderen (1)
outcome (2)
outcome and cognition (1)
Outcome Assessment (1)
Outcome measurement (4)
Outcomes (2)
Outocome (1)
ovarian cancer (1)
Overactieve blaas (2)
overweight (2)
Overweight/obesity (1)
oxidative stress (2)
oxygenation (1)
pain (2)
Pain (Chronic) (1)
PALB2 mutation (1)
palliatief (1)
Palliatieve zorg (3)
palliative care (1)
pancreatic resection (1)
pancreatoduodenectomie (1)
paralysis (1)
parental support (1)
Parkinson disease (4)
Parkinson's disease (4)
Parkinson's disease (2)
Parkinson’s disease (1)
Parkinson's disease (4)
Participation restriction (1)
pathological complete response (1)
pathology (1)
pathway analysis (1)
Patiënt-gerichtheid (1)
patient centered care (1)
patient experiences (2)
Patient perspective (1)
patient related research (1)
patient satisfaction (1)
Patient-Reported-Outcomes (1)
PD-L1 immunohistochemistry (1)
pediatric cardiology (2)
Pediatric gastroenterology (1)
Pediatric rehabilitation (1)
pediatrics (6)
Percutane Nefro-Litholapaxy (2)
Percutaneous coronary intervention (PCI) (1)
Percutaneous intervention (2)
Peri-Acetabular Osteotomy (PAO) or Bernese/Ganz osteotomy (2)
perinatal care and psychiatry (1)
perineal wound healing (1)
periodontitis (1)
perioperative care (1)
Periprosthetic joint infection (1)
peritonitis (1)
Persistent somatic symptoms (1)
personal medicine (1)
personalized (1)
Personalized medicine (3)
personalized treatment (1)
PET (6)
pet scintigraphy (1)
PET-tracer (1)
Peyronie disease (1)
pharmacodynamics (1)
pharmacokinetics (1)
pharmacology (4)
Phelan-McDermid syndrome (1)
phenomenology (1)
phenotype-genotype study (1)
phenylketonuria (1)
photometry (1)
physical activity (3)
physical and mental functioning (1)
physical therapy (1)
physiology (2)
placenta (1)
plasmacytoma (1)
plastic surgery (1)
platelet (1)
polisomnography (1)
Polycomb (1)
polypharmacy (7)
population cohort study (1)
population screening (2)
portal hypertension (1)
Positron Emission Tomography (1)
Postgraduate Medical Education (2)
postoperative complications (2)
postoperative outcome (1)
postoperative pain (1)
posttraumatic (1)
postural control (1)
potassium (1)
pre-clinical imaging (1)
Precision medicine (1)
predictiemodel (1)
Predictiemodellen (1)
prediction (1)
prediction modeling (2)
pregnancy (8)
Prehabilitation (1)
Prematuren (1)
prenatal diagnosis (1)
prenatal diagnostics (2)
prenatal programming (1)
preservation fluids (1)
preterm (1)
preterm birth (1)
Prevalence of cancer (1)
prevention (3)
preventive cardiovascular medication (1)
primairy health care (1)
primary care (7)
primary care, gastro-enteritis, children, out-of-hours service, pediatrics. (2)
Primary Hyperparathyroidism (1)
probiotics (1)
Proefschrift (1)
prognosis (3)
Prolapse surgery (1)
proliferation (1)
Promoveren (1)
prospective cohort study (1)
prostate cancer (1)
Prosthetic Valve (1)
protein aggregation (1)
protein kinase inhibitors (1)
protein restoration therapy (1)
proteomics (3)
prothrombin complex concentrate (1)
PSMA PET/CT (1)
Psychiatric symptoms (1)
psychiatry (1)
psychiatry, high-field MRI (1)
psychological stress (1)
Psychology (1)
psychosis (1)
psychosocial (2)
psychosocial and lifestyle determinants (1)
psychotherapy (1)
Publiceren (1)
pulmonary embolism (1)
pulmonary hypertension (2)
pulmonary rehabilitaion (1)
Pulmonary rehabilitation (1)
QST (1)
qualitative research (3)
quality improvement (1)
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The Impact of Performance Variability in Safety in Healthcare
Keywords: surgery
Safety
team
Researchers:
prof dr JKG Wietasch
M.J. van der Laan
D.A. Dongelmans
Jop Groeneweg
Type of project: MD/PhD programme
Nature of the research:
The total project consists of three fases;
- systematic evaluation of the current impact of performance variability of team performance in healthcare
- developbent of an improvement bundle of interventions
- implementatation and evaluation of the interventions
Fields of study:
anesthesiology
surgery
intensive care
Background / introduction
Beyond doubt stress and fatigue have impact on clinical performance and personal health. Our stress response’ and is governed by a complex interplay of nervous, endocrine, and immunological mechanisms. Fatigue is more intricately linked to three main factors: the work demands of the task at hand; the effort required to sustain performance; and the degree of controllability over the work conditions, which includes the perception of control over the work conditions and the opportunity to execute tasks in various ways. Under conditions of low control, prolonged efforts to maintain performance and the associated high invested effort lead to an adaptive mode of strain (effort with distress) as well as feelings of fatigue. Fatigue could therefore better be conceptualized as a state resulting from the extended use of high-effort control strategies, rather than a mere lack of energy.
In situations of high demand and low control, individuals may react in different ways as the tasks progresses. Firstly, over time, their performance levels may decline as attention wanes, and they may begin to explore alternative, more rewarding possibilities. Secondly, individuals may adjust their goal aspirations for the current task, enabling them to maintain current effort levels while accepting a reduction in performance. Lastly, individuals may choose to increase their level of effort invested, thereby safeguarding task goals.
In the fast-paced and high-stress enviorment like high performance teams in healthcare, the impact of stress and fatigue on performance has been topic of interest. The lack of consensus on the effects of fatigue might underestimate fatigue as cause of physician impairment. Notably, reports indicate that surgeon can be fatigued up to 50% of their time awake, underscoring the importance of evaluating the potential impact of fatigue on performance to ensure a high quality of care.
Research question / problem definition
How can we improve personal and team performance and protect patient safety in high risk high demand settings in healthcare
References
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Dongelmans DA. Grading recommendations for enhanced patient safety in sentinel
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fatigue in surgeons on performance and patient outcome: systematic review. Br J
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PMCID: PMC10771255.
3: Lentz CM, De Lind Van Wijngaarden RAF, Willeboordse F, Hooft L, van der Laan
MJ. Dedicated teams to optimize quality and safety of surgery: A systematic
review. Int J Qual Health Care. 2022 Oct 27;34(4):mzac078. doi:
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4: Koelemay MJW, van der Laan MJ. Opereren van abdominaal aorta aneurysma kan
nog veiliger [Safer surgery for abdominal aortic aneurysm]. Ned Tijdschr
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5: Reijmerink IM, Bos K, Leistikow IP, Groeneweg J, Cnossen F, Dongelmans DA,
van der Laan MJ. Performance variability in perioperative sentinel events:
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