Project details


Influence of allergy on bronchial parameters from low-dose CT in a general Dutch population

CT imaging Radiology image biomarker

dr. R. Vliegenhart
drs. I. Dudurych

Type of project:
Pilot project (year 2 or 3) of Stage Wetenschap / Researchproject

Nature of the research:
Retrospective study based on chest CT scans from a population-based study, called Imaging in Lifelines (ImaLife).

Fields of study:

Background / introduction
Lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (COPD) are called the “big 3” diseases. The “big 3” are on the rise in developed countries, contributing to an increasing health and economic burden. Early detection of respiratory illness may help reduce the development of disease and improve population health. For accurate assessment of airway changes, reference imaging biomarkers require establishment.
Previous research has indicated that atopy has a significant influence on bronchial parameters in the asthma and COPD populations, however the impact of allergic traits is unclear in the general population.
Research question / problem definition
We propose to investigate whether there are differences in bronchial parameters of the general population due to allergic traits such as hay-fever.
Artificial intelligence methods have been developed to automatically quantify bronchial parameters such as the airway luminal area and percentage wall area. These tools can be used on Imaging in Lifelines scans (ImaLife) to measure bronchial parameters in the general population. This unique dataset is linked with data from the Lifelines project and allows for investigation into the change in bronchial parameters in an individual based on multiple factors. The results of this study give insight into the influence of allergy on bronchial parameters, and how this relates to pulmonary disease.
Xia C, Rook M, Pelgrim GJ, et al (2019) Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study. Eur J Epidemiol.
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