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allergology (8)
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cardiology (35)
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cell biology (47)
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epidemiology and statistics (20)
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medical education (2)
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Patient Related Research (5)
pediatrics (70)
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urology (9)
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(medical)genetics (5)
5jaars overleving (1)
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abdomen (1)
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Achilles tendinopatie (1)
ACS-NSQIP surgical risk calculator (1)
activated clotting time (1)
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acute myocardial infarction (2)
adpkd (1)
Advanced cell culture (1)
Advanced imaging (1)
Advanced Microscopy (2)
Advice (1)
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ageing (4)
ageing lungs (1)
Ageing, Nuclear Envelope, Nuclear Pore Complex (1)
aging (1)
airway epithelium (1)
Alcohol (1)
Allergen immunotherapy (1)
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Allergy (1)
allogene stam cel transplantatie (1)
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Amalgaam (2)
ambulance (1)
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anesthesia (5)
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anesthesiology (2)
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Animal research (1)
ankylosing spondylitis (2)
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antibiotics (2)
anticoagulants (2)
antidepressants (2)
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anxiety (1)
Aorta (2)
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arrhythmia (1)
arterioveneuze fistel, dialyse shunt (1)
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asthma (6)
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astma (1)
asylum seekers (1)
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autoantibodies (2)
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autoimmune disease (6)
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Autophagy (2)
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basic research (2)
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beta cell destruction (1)
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brain metastases (1)
brain tumour (2)
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Breast augmentation mammoplasty (2)
breast cancer (3)
breast conserving surgery (1)
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bronchial epithelium (1)
built environment (1)
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Calprotectin (2)
cancer (27)
cancer cell apoptosis (1)
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cancer cells (1)
cancer patients (2)
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Cardiac Amyloidosis (2)
cardiac differentiation (1)
cardiac output (1)
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cardiogenetics (2)
cardiology (10)
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cardiovascular (4)
cardiovascular disease (5)
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care outside the guideliness (1)
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Catheterization lab (1)
celiac disease (4)
cell biology (1)
cell cycle (2)
cell death (3)
cell saver (1)
cellbiology (1)
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Cervical spine (2)
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children (6)
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cholesterol fluxes (1)
chromosomal abnormalities (1)
chromosome (1)
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Chronic Kidney Disease (5)
chronic lung allograft dysfunction (1)
chronic ventilatory support (1)
Chronische pijn (2)
Circadian rhythmicity (1)
cirrhosis (2)
Clinical decision making (1)
clinical decision-making (1)
clinical diagnostics (4)
Clinical Severity Score (1)
co-morbidity (1)
coagulation (1)
coating (1)
coccygodynie (1)
cochlear implant users (1)
cognition and outcome (2)
cognitive function (3)
cognitive impairment (1)
cognitive testing (1)
collect clinical information (1)
Colon carcinoma (1)
colonisation (1)
colorectal cancer (3)
colorectal cancer, CEA value, CT-scan, follow up (1)
colorectal surgery (1)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (1)
competency development (1)
complement (3)
complex congenital heart disease (1)
compliance (1)
complications (3)
Comprehensice geriatric assessment (1)
computed tomography (CT) (3)
Congenital anomalies (1)
congenital heart disease (3)
connective tissue disease (1)
Constipation (1)
continue glucose monitoring (2)
contraction (1)
contrastmiddel (1)
COPD (15)
Coronair angiografie (1)
coronary arteries (1)
coronary artery bypass grafting (1)
Coronary Artery Disease (3)
cosmetic outcome (1)
costs (2)
COVID-19 (5)
craniopharyngioma (2)
Craniotomy (1)
Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
CT (1)
CT-scan (1)
cystic fibrosis (4)
cytokines (1)
data management (1)
database (3)
database registry (1)
Deep brain stimulation (DBS) (4)
deletion (2)
delirium (1)
delivery agent (1)
dementia (3)
dental erosion (1)
dental hygiene (1)
dentist (1)
depression (4)
Depression, (1)
Depression, translational neuroscience (1)
dermatology (2)
development (3)
Developmental coordination disorder (1)
developmental disorder (1)
developmental disorders (1)
developmental psychopathology (1)
Dexamethasone (1)
diabetes (3)
Diabetes mellitus (4)
diabetis (1)
diagnostic importance (1)
diagnostic test (1)
diagnostics (2)
dialysis (3)
Diaphragm paralysis (2)
Diet (1)
dilated cardiomyopathy (1)
disease activity (1)
disease models (1)
DNA (1)
DNA damage (1)
DNA damage response (1)
DNA methylation signatures (1)
donor (1)
Drosophila (2)
drug delivery (1)
Drug Interactions (1)
dry eye (1)
duplication (1)
Dupuytren's disease (1)
Dystonia (4)
e-health (5)
early detection (1)
Early Onset Ataxia (2)
echo duplex, diagnotische waarde (1)
echocardiography (2)
echogenic bowel (1)
Education (2)
EEG-EMG (1)
effects (1)
Ehealth (9)
Elder (1)
elderly (5)
elderly cancer patients (1)
elderly patients (2)
electroconvulsive therapy (1)
Electronic Nose (1)
EMG (1)
EMG-analysis (1)
emphysema (1)
EMSA (1)
enamel (1)
end-expiratory lung volume (1)
endocrine disrupting chemicals (1)
endocrine therapy (1)
endometriosis (2)
Endophenotypes (1)
Endothelial Cell (2)
endothelial cells (1)
endoveneuze laser behandeling (1)
energy metabolism (3)
engineering (1)
enkelletsel (1)
eNose (1)
epidemiology (8)
epidermolysis bullosa (1)
epigenetics (4)
epithelial cells (1)
epithelial disorders (1)
errors (1)
erythropoietin (1)
Esophageal cancer (1)
esophageal carcinoma (2)
Esophageal pressure (1)
esophagus surgery (1)
Essential tremor (2)
ESWL (2)
ethics (1)
evidence-based medicine (1)
EVLT (1)
Ex vivo lung perfussion (1)
exercise testing (1)
exercise therapy (1)
Exercise training (1)
Exergames (1)
exome sequencing (3)
Extreme prematuur (1)
Faecalibacterium prausnitzii (1)
familial hypercholesterolemia (1)
Family history (2)
Farmacologie (1)
farmacology (1)
fatigue (2)
fatty acids (1)
fatty liver disease (1)
FDG PET/CT (2)
fecal incontinence (1)
fertility (1)
fetal gender (1)
fibrosis (3)
filling (2)
First Episode Psychosis (2)
first trimester anomaly scan (1)
first trimester ultrasound (1)
fitness (1)
fluid administration, hemodynamic monitoring (1)
Fluorescence imaging (1)
fNIRS-monitoring (1)
Follow-up (1)
foot ulcers (1)
frailty (2)
Frailty screening (2)
functional genetics (2)
Functional stroke mimic (1)
Fungal Infections (1)
fysiotherapie (1)
gait (1)
galectin-3 (1)
Galgangatresie (1)
game (1)
gangliosides (1)
GECKO (3)
Gender (1)
gene enrichment (1)
gene expression (1)
gene regulation (1)
general movements (1)
general practice (2)
general practitioner (1)
genetic diseases (1)
Genetic sequencing (1)
genetic testing (1)
genetics (5)
genome analysis (1)
genomic instability (1)
genotype-phenotype correlation (1)
geriatric oncology (1)
geriatrics (2)
glaucoma (2)
Glioblastoma (1)
Gliomas (1)
global child health (1)
global health (1)
Glomerular filtration rate (1)
Glucocorticoids (1)
glucose homeostasis (1)
Group antenatal care (1)
growth hormone deficiency (1)
Guidelines (2)
Gunanine Nucleotide Exchange Factor (1)
Gut Microbiota Composition (2)
gut-liver acis (1)
gyneacological oncology (1)
haemophilia (2)
hand (1)
Head and neck cancer (5)
Health care utilization (1)
health economics (1)
Health indicators (1)
Health literacy (1)
health-related quality of life (4)
hearing impairment (1)
hearing rehabilitation (1)
heart (14)
heart failure (7)
heart transplantation (1)
heart valve replacement (1)
heat shock proteins (1)
Heel prick Screening (1)
hematology, cancer, critical care, outcome (3)
hematopoiesis (5)
hemodynamic monitoring (2)
hemodynamics (1)
hemostasis (2)
heparin induced thrombocytopenia (1)
hepatitis (2)
hereditary kidney disease (1)
hereditary tumours (1)
herniated discs (1)
HFOV (2)
Hibernation (4)
Hidradenitis suppurativa (1)
hip and knee prothesis (2)
Hip artroplasty (1)
Historical controls (1)
HIV (3)
HNPCC (1)
Hodgkin lymphoma (2)
Home mechanical ventilation (2)
home treatment (1)
Honours education (1)
hormone receptors (1)
HPB surgery (1)
huisarts (1)
Huisartsgeneeskunde (1)
human genetics (1)
human hematopoietic stem cells (3)
Humeral Fractures (1)
hydrochlorothiazide (1)
hydrogen sulfide (1)
hymenoptera venom allergy (1)
Hypertensie (1)
hypoglycemia (1)
hypophospatemic rickets (1)
hypoplastic left heart syndrome (1)
hypotension (1)
IBD (1)
IGF-1 (1)
imaging (7)
imaging, biomarkers (2)
Immune checkpoint inhibitors (3)
immune response (1)
immune suppression (1)
Immune-related adverse events (1)
immunity (1)
immunology (10)
immunosuppression (1)
immunotherapy (4)
implant infection (2)
in vitro (1)
in vitro fertilization (1)
incidence (1)
incontinence (2)
individualised treatment (1)
infant (2)
infant assessment (2)
infant development (3)
Infant Stool Colour Card (1)
infection (3)
Infectious diseases (1)
Infective Endocarditis (1)
inflammation (5)
Inflammatory bowel disease (3)
Inflammatory rheumatic disease (2)
Informatie-uitwisseling (1)
Information technology (1)
Inguinal Hernia Surgery (1)
innovatie van zorg (1)
insulin (1)
insuline-glucose metabolism (1)
insulitis (1)
intellectual disability (1)
interactie (1)
interventions in obstetrics (1)
intestinal disease (2)
intestinal disorder (1)
intestinal integrity (1)
intestinal transplantation (2)
Intestinal wall permeability (1)
intestine (1)
Intracraniele druk (1)
iPSC (1)
iron deficiency (1)
ischemia (3)
ischemia/reperfusion injury (2)
ischemic stroke (1)
Isolation (1)
isotopes (1)
IVF (3)
jaundice (2)
Ki67 proliferation index (1)
kidney (6)
kidney disease (5)
Kidney Donation (3)
kidney transplantation (12)
kidneydonor (1)
kinetic modeling (1)
Klinische onderzoeksstage (1)
knockout mouse (1)
kwaliteit van leven (2)
kwaliteit van zorg (1)
laboratory animals (10)
language development (1)
language screening (1)
laparoscopy (1)
laryngectomy (3)
learning curve sonologist (1)
leefstijl (1)
leukemia (3)
leukemic stem cells (2)
LifeLines (2)
lifestyle (3)
lifestyle intervention (1)
liposomes (1)
lipotoxicity (1)
liver (3)
liver cancer (1)
liver disease (5)
liver diseases (1)
liver failure (1)
liver fibrosis (1)
liver metastases (1)
liver resection (1)
liver transplantation (9)
livercirrhosis (1)
locally advanced rectal caner (1)
locomotion (1)
long-term survival (1)
lumg transplantation (1)
lung (3)
lung cancer (4)
lung mechanics (2)
lung nodules (2)
lung recruitment (1)
lung transplantation (4)
lymphoma (2)
machine learning (Matlab/Rstudio) (1)
machine perfusion (2)
major depressive disorder (1)
mass spectrometry (2)
mast cells (1)
mastocytosis (3)
mechanical ventilation (9)
medical comorbidity (1)
medical device (4)
medical education (1)
medical imaging (7)
medically unexplained symptoms (2)
medication (3)
Medication reviews (1)
medication safety (1)
medicine (1)
melanoma (4)
Meningioma (1)
meno-pauze (1)
mental retardation (1)
metabolic diseases (4)
Metabolic signaling (1)
metabolic syndrome (3)
metabolism (3)
metabool syndroom (3)
metformin (1)
method development (3)
microbiome (1)
microbiota (3)
microcephaly (1)
Microglia (1)
microRNA (2)
microsatellite instability (1)
Minimally invasive parathyroidectomy (1)
mismatch repair (1)
mitochondria (1)
MitraClip (1)
Mobile electrocardiogram devices (1)
Mobility (1)
Modus partus (1)
molecular biology (2)
molecular chaperones (1)
Molecular Fluorescence Guided Surgery (1)
molecular mechanisms (1)
molecular microbiology (1)
Molecular tumour board (1)
molecular typing (1)
monocytes (1)
mood disorders (1)
Motor development (2)
Mouse models (1)
movement disorders (3)
MRI (7)
MRI / CT (1)
MRI / magnetic resonance imaging (3)
MRS (1)
mucus clearance (1)
multi-morbidity (1)
Multi-organ failure (1)
Multi-phase CT (1)
multidrug resistance (1)
Multimorbidity (2)
multiple myeloma (2)
multiple sclerosis (3)
Musculoskeletal pain (1)
Music (1)
mutations (2)
myelin (1)
myocardial infarction (2)
myoclonus (1)
NASH (1)
nasopharyngeal carcinoma (1)
Necrotische Enterocolitis (1)
necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
neoadjuvant chemoradiotherapy (1)
Neonatal growth (1)
neonatal hypoglycemia (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
Neonatal outcome (1)
neonates (2)
nephrology (1)
neuro-endocrine tumors (1)
neurobiology (1)
neurocognition (1)
neurodegeneration (4)
neurodegenerative diseases (3)
neurodevelopmental impairment (1)
neurodevelopmental outcome (1)
neuroendocrine tumor (1)
Neuroimaging (2)
neurological development (1)
neurology (1)
neuromuscular blockade (1)
neuropathic pain (1)
neuropathy (1)
neuropsychiatric symptoms (1)
Neurosurgery (1)
neurotransmitters (1)
neutropenia (1)
new genes (1)
nier (1)
non-Hodgkin's disease (1)
Non-invasive ventilation (4)
Non-motor symptoms (2)
Noordzeeziekte (1)
nuclear receptors (1)
nursing home (1)
Nursing home residentss (1)
nutrient addiction (1)
nutrition (6)
obesity (6)
Occupational exposures (1)
Occupational health (1)
Older adults (1)
oligodendrocytes (1)
oncological epidemiology (1)
oncology (4)
oncoplastic surgery (1)
ongeplande heropname (1)
online wearables (1)
operative surgical procedure (1)
opthalmologic problems (1)
organ preservation (3)
organ transplant (1)
organ transplantation (1)
orthopedics (3)
osteomyelitis (1)
otolaryngology (1)
Ouderen (1)
outcome and cognition (1)
Outcome Assessment (1)
Outcome measurement (5)
Outcomes (2)
ovarian cancer (3)
Overactieve blaas (2)
overweight (3)
Overweight/obesity (1)
oxidative stress (2)
oxygenation (1)
pain (2)
palliatief (1)
Palliatieve zorg (3)
palliative care (1)
pancreatic resection (1)
pancreatoduodenectomie (1)
parental support (1)
Parkinson disease (4)
Parkinson's disease (4)
Parkinson's disease (1)
Parkinson’s disease (1)
Parkinson's disease (4)
Participation restriction (1)
pathological complete response (1)
pathology (1)
pathway analysis (1)
patient centered care (1)
patient experiences (2)
Patient perspective (1)
patient related research (1)
patient satisfaction (1)
Patient-Reported-Outcomes (1)
PD-L1 immunohistochemistry (1)
pediatric cardiology (2)
Pediatric rehabilitation (1)
pediatrics (4)
Percutane Nefro-Litholapaxy (2)
Percutaneous coronary intervention (PCI) (1)
Percutaneous intervention (2)
perinatal care and psychiatry (1)
perineal wound healing (1)
periodontitis (1)
perioperative care (1)
Periprosthetic joint infection (1)
peritonitis (1)
personal medicine (1)
Personalized medicine (1)
PET (4)
pet scintigraphy (1)
PET-tracer (1)
Peyronie disease (1)
pharmacodynamics (1)
pharmacokinetics (1)
pharmacology (1)
Phelan-McDermid syndrome (1)
phenomenology (1)
phenotype-genotype study (1)
photometry (1)
physical activity (4)
physical and mental functioning (1)
physical therapy (1)
physiology (2)
placenta (1)
plasmacytoma (1)
plastic surgery (1)
platelet (1)
polisomnography (1)
Polycomb (1)
polypharmacy (6)
population screening (2)
portal hypertension (1)
Positron Emission Tomography (1)
Postgraduate Medical Education (1)
postoperative complications (2)
postoperative outcome (1)
posttraumatic (1)
postural control (1)
potassium (1)
pre-clinical imaging (1)
predictiemodel (1)
Predictiemodellen (1)
prediction (1)
prediction modeling (2)
preeclampsia (1)
pregnancy (6)
Prematuren (1)
prenatal diagnosis (2)
prenatal diagnostics (2)
prenatal programming (1)
preservation fluids (1)
preterm (1)
preterm birth (1)
Prevalence of cancer (1)
prevention (3)
primairy health care (1)
primary care (4)
primary care, gastro-enteritis, children, out-of-hours service, pediatrics. (2)
Primary Hyperparathyroidism (1)
probiotics (2)
prognosis (2)
Prolapse surgery (1)
proliferation (1)
Prosthetic Valve (1)
protein aggregation (1)
protein kinase inhibitors (1)
protein restoration therapy (1)
proteomics (3)
prothrombin complex concentrate (1)
Psychiatric symptoms (1)
psychiatry (1)
psychiatry, high-field MRI (1)
Psychology (1)
psychosis (1)
psychosocial (2)
psychotherapy (1)
pulmonary embolism (1)
pulmonary hypertension (1)
pulmonary rehabilitaion (1)
QST (1)
qualitative research (2)
quality of life (7)
quality of reduction (1)
Quantification (1)
quantitative sensory testing (1)
questionnaire (3)
questionnaire research (1)
Radiology (9)
radiotherapy (27)
Randomized comparative trial (1)
randomized controlled trial (1)
raynaud (1)
real world dosing (1)
Recommendation (1)
rectal cancer (1)
rectum carcinoma (1)
referral (1)
Refugee women (1)
refugees (1)
regeneration (2)
rehabilitation (5)
Relatives (2)
renal disease (2)
renal transplantation (1)
renal tubular epithelium (1)
reperfusion (2)
Reproducibility of Results (1)
Reproduction (1)
reproductive health (1)
reproductive immunology (2)
respiratory failure (1)
respiratory viruses (1)
restoration (1)
retina (2)
retinal physiology (1)
retrospective (1)
revision surgery (1)
rheologic and oxygen transport capacity (1)
risk factors (1)
RNA (1)
Robot-assisted surgery (1)
ROC curve (1)
running (1)
saliva (1)
SARS-CoV-2 vaccination (1)
Schildklierkanker (1)
schizophrenia (3)
screening (2)
Screening tools (2)
Seating devices (1)
Second opinion (1)
Self - Determination Theory (1)
self-management (1)
self-renewal (2)
sensitisatie van het centraal zenuwstelsel (1)
Sentinel lymph node (1)
Sepsis (2)
serious gaming (1)
severe mental disorders (1)
sex-specific (1)
shared decision making (1)
signal transduction (1)
Single Nucleotide Polymorphisms (SNP) (1)
siRNA (1)
Sjögren's syndrome (1)
skeletal muscle mass (1)
Skin cancer (3)
SLE (2)
Sleep (1)
small for gestational age (1)
small molecular drugs (1)
Social media (1)
soft tissue sarcoma (2)
spataderen (1)
spectroscopy (1)
sport (1)
sport medicine (1)
sports injury (1)
Stage wetenschap / research project (1)
statistics (1)
steatosis hepatis (1)
Stem cell division (2)
stem cells (4)
stenose (1)
Streptococcus pneumoniae (2)
stress (3)
stroke (2)
Stuitbevalling (1)
stuitpijn (1)
subarachnoid hemorrhage (1)
surgery (7)
surgery induced muscle loss (1)
surgical oncology (2)
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Automatic speech analysis for early detection of delirium
Keywords: delirium
Researchers:
prf. dr. B. van Munster
S.G. Brederoo
Nature of the research:
Prospective cohort study
Fields of study:
health psychology
geriatrics
Background / introduction
Older patients, especially frail older patients are at risk for postoperative delirium. In daily practice delirium is frequently missed leading to negative outcomes like complications and long term cognitive impairment. Often prodromal symptoms precede the full-blown syndrome, providing an ideal opportunity to optimize non-pharmacological preventive interventions for delirium. Diagnosis of delirium is based on psychiatric examination using among others impressions of speech. Automatically extracted speech parameters have been shown to accurately discriminate patients with a schizophrenia-spectrum disorder from healthy controls and might be able to classify delirium as well.
Research question / problem definition
1. Are automatically extracted speech parameters able to discriminate delirious from non-delirious patient?
2. Are automatically extracted speech parameters able to predict delirium?
Workplan
We will include 100 patients aged >70 years after a planned surgical procedure. Inclusion criterium is an increased risk for delirium based on the VMS criteria for delirium and the Dutch language as mother tongue. Exclusion criteria: no informed consent, speech disorder (e.g. stutter), uncorrected hearing impairment. Patients will be monitored daily by the delirium observations scale (DOS). In case of DOS>3 a physician will diagnose delirium according to the DSM5 criteria.
Speech will be recorded daily with a structured interview of 5 minutes. Acoustic parameters will be extracted with OpenSMILE, including a range of acoustic features such as speech quality and pauses. Speech parameters will be fed into a random forest algorithm with leave-ten-out cross-validation to assess their value for a delirium diagnosis.
You will write a report on the results, which can be optionally submitted for publication in a scientific journal.