Project details
Choose a field of study
allergology (9)
anesthesiology (28)
biomaterials (12)
cardiology (36)
cardiology and thoracic surgery (14)
cell biology (47)
child and adolescent psychiatry (1)
dentistry (4)
dermatology (10)
diabetes (7)
endocrinology (12)
ENT medicine (10)
epidemiology (55)
epidemiology and statistics (19)
gastroenterology (54)
general internal medicine (9)
genetics (43)
geriatrics (20)
GP medicine (40)
gynaecology (18)
haematology (25)
health psychology (17)
health sciences (23)
immunology (35)
intensive care (21)
internal medicine (36)
laboratory medicine (8)
mass spectrometry (3)
medical biology (18)
medical education (5)
medical physiology (7)
microbiology (22)
molecular biology (33)
molecular imaging (5)
movement sciences (15)
nephrology (40)
neurology (67)
neurosurgery (11)
nuclear medicine (16)
obstetrics (13)
obstetrics (9)
oncology (76)
ophthalmology (6)
orthopedics (17)
pathology (17)
Patient Related Research (8)
pediatrics (76)
pharmacology (28)
plastic surgery (5)
psychiatry (36)
pulmonology (40)
radiology (54)
radiotherapy (7)
rehabilitation (21)
reumatology (13)
Sociale Geneeskunde (14)
Sociale Psychiatrie (2)
sports medicine (4)
Stamcelbiologie (3)
Straling en Stresscelbiologie (1)
Stralingswetenschappen (3)
surgery (86)
traumatology (8)
tropical medicine (7)
urology (10)
vascular medicine (20)
virology (2)
or
Choose a keyword
(Epi)genetic epidemiology (1)
(medical)genetics (5)
5jaars overleving (1)
:psychosocial and lifestyle determinants (4)
abdomen (1)
access to medicine (1)
ACE-inhibitor (1)
Acetabular fracture (1)
Acetylcholine (1)
Achilles tendinopathy (1)
Achilles tendinopatie (1)
ACS-NSQIP surgical risk calculator (1)
activated clotting time (1)
Acute gastroenteritis (1)
Acute Myeloid Leukemia (1)
acute myocardial infarction (2)
adpkd (3)
Advanced cell culture (1)
Advanced imaging (1)
Advanced Microscopy (2)
adverse side effects (1)
Advice (1)
Africa (2)
ageing (4)
ageing lungs (1)
Ageing, Nuclear Envelope, Nuclear Pore Complex (1)
aging (1)
airway epithelium (1)
Alcohol (2)
Allergen immunotherapy (1)
Allergic asthma (1)
Allergologie (1)
Allergy (1)
allogene stam cel transplantatie (2)
Allogeneic stem cell transplantation (1)
Alternative for epidural analgesia (1)
Amalgaam (2)
ambulance (1)
Anaphylaxis (1)
ANCA associated vasculitis (1)
anesthesia (5)
Anesthesiologie (1)
anesthesiology (2)
angiogenesis (1)
animal models (1)
Animal research (2)
ankylosing spondylitis (2)
antenatal care (1)
Anti-epileptics (1)
Antibiotic allergy (1)
antibiotics (3)
anticoagulants (2)
antidepressants (4)
Antimicrobial resistance (2)
Antimicrobial Stewardship (1)
anxiety (1)
Aorta (1)
aortic stenosis (1)
Apoptosis (1)
Appendicitis (2)
arrhythmia (1)
arterioveneuze fistel, dialyse shunt (1)
Artificial Intelligence (3)
Aspergillus fumigatus (1)
Assessment (1)
asthma (7)
Asthma genes (1)
astma (1)
asylum seekers (1)
Ataxia (2)
atherosclerosis (4)
Atrial fibrillation (3)
Attitude medisch specialisten (1)
audiology (1)
autism (1)
auto-antibodies (1)
autoantibodies (1)
autoantigen (1)
autoimmune blistering diseases (1)
autoimmune disease (6)
autologous stem cell transplantation (1)
Autophagy (2)
Axonal transport (1)
Balance (1)
bariatric surgery (1)
basic research (2)
Behandeling/follow-up (1)
Beslissingsondersteuning (1)
beta cell destruction (1)
Big Data (2)
Bijnier (1)
bile (3)
bile ducts (1)
biliary atresia (4)
bilirubin (1)
bio-informatics (1)
biochemie (2)
biofilm (1)
bioinformatics (1)
biomarker (2)
biomarkers (9)
biomaterials (1)
biomedical technology (3)
biorhythm (1)
bipolar disorder (3)
bleeding (2)
blood flow autoregulation (1)
blood loss (1)
Blood pressure (2)
Blood pressure variability (1)
blood-brain barrier (1)
bloodpressure (1)
borderline tumors of the ovary (1)
brain (3)
brain metastases (2)
brain tumour (2)
BRCA1/2 (1)
BRCA1/2 mutation (1)
Breast (a)symmetry (1)
Breast augmentation mammoplasty (2)
breast cancer (5)
breast conserving surgery (1)
Breast implants (1)
Breast symmetry (1)
bronchial epithelium (1)
built environment (1)
Buruli Ulcer (3)
Calorie restriction (1)
Calprotectin (2)
cancer (31)
cancer cell apoptosis (1)
Cancer cell metabolism (1)
cancer cells (1)
cancer patients (2)
cannabis (1)
carcinogenesis (1)
Cardiac Amyloidosis (2)
cardiac differentiation (1)
Cardiac function (1)
cardiac output (1)
cardiac surgery (1)
cardio-pulmonary toxicity (1)
cardiogenetics (2)
cardiology (10)
cardiometabolic health (1)
cardiopulmonary bypass (1)
Cardiovasculaire effecten (1)
cardiovascular (4)
cardiovascular disease (6)
cardiovascular risk (1)
cardiovascular risk management (1)
cardiovascular surgery (1)
Cardiovascular toxicity (2)
care outside the guideliness (1)
caries (1)
carriers (1)
cartilage (2)
Catheterization lab (1)
celiac disease (4)
cell biology (1)
cell cycle (2)
cell death (3)
cell saver (1)
cellbiology (1)
cellular interactions (1)
cerebral palsy (1)
cervical radiculopathy (1)
Cervical spine (2)
cesarean delivery (1)
CHARGE syndrome (2)
chemotaxis (1)
chemotherapy (5)
chest CT (1)
child (2)
Child development (1)
child outcome (1)
childbirth (1)
children (7)
ChIP assay (1)
cholangiocyte (1)
cholestasis (1)
cholesterol fluxes (1)
chromosomal abnormalities (1)
chromosome (1)
chronic depression (2)
chronic disease (2)
Chronic Kidney Disease (5)
chronic lung allograft dysfunction (1)
chronic ventilatory support (1)
Chronische pijn (2)
Circadian rhythmicity (1)
cirrhosis (2)
Clinical decision making (1)
clinical decision-making (1)
clinical diagnostics (4)
clinical epidemiology (1)
clinical genetics (1)
Clinical retrospective patient outcome study (1)
Clinical Severity Score (1)
co-morbidity (1)
coagulation (1)
coating (1)
coccygodynie (1)
cochlear implant users (1)
cognition and outcome (2)
cognitive function (3)
cognitive impairment (1)
cognitive testing (1)
collect clinical information (1)
Colon carcinoma (1)
colonisation (1)
colorectal cancer (2)
colorectal cancer, CEA value, CT-scan, follow up (1)
colorectal surgery (3)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (1)
competency development (1)
complement (3)
complex congenital heart disease (1)
compliance (1)
complications (4)
Comprehensice geriatric assessment (1)
computed tomography (CT) (3)
Congenital anomalies (1)
congenital heart disease (3)
connective tissue disease (1)
Constipation (1)
continue glucose monitoring (1)
contraction (1)
contrastmiddel (1)
COPD (14)
Coronair angiografie (1)
coronary arteries (1)
coronary artery bypass grafting (1)
Coronary Artery Disease (3)
cosmetic outcome (1)
costs (3)
COVID-19 (6)
craniopharyngioma (2)
Craniotomy (1)
Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
CT (1)
CT imaging (2)
CT-scan (1)
cystic fibrosis (4)
cytokines (1)
Damage (1)
database (3)
database registry (1)
Deep brain stimulation (DBS) (4)
deletion (2)
delirium (1)
delivery agent (1)
dementia (3)
dental erosion (1)
dental hygiene (1)
dentist (1)
depression (4)
Depression, (2)
Depression, translational neuroscience (1)
dermatology (3)
development (3)
Developmental coordination disorder (1)
developmental disorder (1)
developmental disorders (1)
Developmental Dysplasia of the Hip (DDH) (1)
developmental psychopathology (1)
Dexamethasone (1)
diabetes (3)
Diabetes mellitus (4)
diabetis (1)
diagnostic importance (1)
diagnostic test (1)
diagnostics (3)
dialysis (3)
Diaphragm paralysis (1)
Diet (2)
dilated cardiomyopathy (1)
disease activity (1)
disease models (1)
Disease modifying therapy (1)
DNA (1)
DNA damage (1)
DNA damage response (1)
DNA methylation signatures (1)
donor (1)
Drosophila (2)
drug delivery (1)
Drug Interactions (1)
dry eye (2)
duplication (1)
Dupuytren's disease (1)
Dupuytren's disease (1)
Dystonia (4)
e-health (5)
early detection (1)
Early Onset Ataxia (2)
echo duplex, diagnotische waarde (1)
echocardiography (2)
echogenic bowel (1)
eco-anxiety (1)
Education (2)
EEG-EMG (1)
effects (1)
Ehealth (10)
Elder (1)
elderly (6)
elderly cancer patients (1)
elderly patients (2)
electroconvulsive therapy (1)
Electronic Nose (1)
EMG (1)
EMG-analysis (1)
emphysema (1)
EMSA (1)
enamel (1)
end-expiratory lung volume (1)
endocrine disrupting chemicals (1)
endocrine therapy (1)
endocrinology (1)
endometriosis (2)
Endophenotypes (1)
Endothelial Cell (2)
endothelial cells (1)
endoveneuze laser behandeling (1)
energy metabolism (3)
engineering (1)
enkelletsel (1)
eNose (1)
epidemiology (9)
epidermolysis bullosa (1)
epigenetics (4)
epithelial cells (1)
epithelial disorders (1)
ercp (1)
errors (1)
erythropoietin (1)
Esophageal cancer (1)
esophageal carcinoma (2)
Esophageal pressure (1)
esophagus surgery (2)
Essential tremor (3)
ESWL (2)
ethics (1)
evidence-based medicine (1)
EVLT (1)
Ex vivo lung perfussion (1)
exercise testing (1)
exercise therapy (1)
Exercise training (1)
Exergames (1)
exome sequencing (3)
Extreme prematuur (1)
Faecalibacterium prausnitzii (1)
familial hypercholesterolemia (1)
Family history (2)
Farmacologie (1)
farmacology (1)
fatigue (2)
fatty acids (1)
fatty liver disease (1)
FDG PET/CT (2)
fecal incontinence (1)
fertility (1)
fetal gender (1)
fibrosis (3)
filling (2)
First Episode Psychosis (2)
first trimester anomaly scan (1)
first trimester ultrasound (1)
fitness (1)
fluid administration, hemodynamic monitoring (1)
Fluorescence imaging (1)
fMRI (1)
fNIRS-monitoring (1)
foot ulcers (1)
frailty (2)
Frailty screening (2)
functional genetics (2)
Functional stroke mimic (1)
Fungal Infections (1)
fysiotherapie (1)
gait (1)
galectin-3 (1)
Galgangatresie (1)
game (1)
gangliosides (1)
GBA1-gene (1)
GECKO (1)
Gender (1)
gene enrichment (1)
gene expression (1)
gene regulation (1)
general medicine (1)
general movements (1)
general practice (3)
general practitioner (1)
genetic diseases (1)
Genetic sequencing (1)
genetic testing (1)
genetics (5)
genome analysis (1)
genomic instability (1)
genotype-phenotype correlation (1)
geriatric oncology (1)
geriatrics (2)
glaucoma (2)
Glioblastoma (1)
Gliomas (1)
global child health (1)
global health (2)
Glomerular filtration rate (1)
Glucocorticoids (1)
glucose homeostasis (1)
Group antenatal care (1)
growth hormone deficiency (1)
Guidelines (2)
Gunanine Nucleotide Exchange Factor (1)
Gut Microbiota Composition (2)
gut-liver acis (1)
gyneacological oncology (1)
gynecological oncology surgery (1)
haemophilia (2)
hand (1)
Head and neck cancer (5)
Health care professionals (1)
Health care utilization (1)
health economics (3)
Health indicators (1)
Health literacy (1)
health-related quality of life (4)
healthcare education (1)
hearing impairment (1)
hearing rehabilitation (1)
heart (14)
heart failure (7)
heart transplantation (1)
heart valve replacement (1)
heat shock proteins (1)
Heel prick Screening (1)
hematology, cancer, critical care, outcome (3)
hematopoiesis (5)
hemodynamic monitoring (2)
hemodynamics (1)
hemostasis (2)
heparin induced thrombocytopenia (1)
hepatitis (2)
hepatocellular carcinoma (1)
hereditary cancer (1)
hereditary kidney disease (1)
hereditary tumours (1)
herniated discs (1)
HFOV (2)
Hibernation (4)
Hidradenitis suppurativa (1)
hip (1)
hip and knee prothesis (2)
Hip artroplasty (1)
Historical controls (1)
HIV (3)
Hodgkin lymphoma (2)
Home mechanical ventilation (3)
Honours education (1)
hormone receptors (1)
HPB surgery (1)
huisarts (1)
Huisartsgeneeskunde (1)
human genetics (1)
human hematopoietic stem cells (3)
Humeral Fractures (1)
hydrochlorothiazide (1)
hydrogen sulfide (1)
hymenoptera venom allergy (1)
hyperglycaemia (1)
Hyperkinetic movement disorders (2)
Hypertensie (1)
hypoglycemia (1)
hypophospatemic rickets (1)
hypoplastic left heart syndrome (1)
hypotension (1)
IBD (4)
IGF-1 (1)
image biomarker (2)
imaging (10)
imaging, biomarkers (1)
Immune checkpoint inhibitors (3)
immune response (1)
immune suppression (1)
Immune-related adverse events (1)
immunity (1)
immunology (11)
immunosuppression (1)
immunotherapy (4)
implant infection (2)
in vitro (1)
in vitro fertilization (1)
Inborn Error of Metabolism (1)
incidence (1)
incontinence (2)
individualised treatment (1)
infant (2)
infant assessment (2)
infant development (3)
Infant Stool Colour Card (1)
infection (3)
Infectious diseases (1)
Infective Endocarditis (1)
inflammation (5)
Inflammatory bowel disease (3)
Inflammatory rheumatic disease (3)
Informatie-uitwisseling (1)
Information technology (1)
Inguinal Hernia Surgery (1)
innovatie van zorg (2)
insulin (1)
insuline-glucose metabolism (1)
insulitis (1)
Integrative care (1)
intellectual disability (1)
interactie (1)
interprofessional education (2)
interventions in obstetrics (1)
Interviews (1)
Interviewstudie (1)
intestinal disease (2)
intestinal disorder (1)
intestinal integrity (1)
intestinal transplantation (2)
Intestinal wall permeability (1)
intestine (1)
Intracraniele druk (1)
Intraoperative neurophysiology (1)
IONM (1)
iPSC (1)
iron deficiency (2)
ischemia (3)
ischemia-reperfusion injury (1)
ischemia/reperfusion injury (2)
ischemic stroke (2)
Isolation (1)
isotopes (1)
IVF (3)
jaundice (2)
joint (2)
Ki67 proliferation index (1)
kidney (6)
kidney disease (5)
Kidney Donation (3)
kidney transplantation (13)
kidneydonor (1)
kinetic modeling (1)
Klinische onderzoeksstage (1)
knockout mouse (1)
kwaliteit van leven (2)
kwaliteit van zorg (1)
laboratory animals (10)
language development (1)
language screening (1)
laparoscopy (1)
laryngectomy (3)
late effects of treatment (1)
Leadership (1)
learning curve sonologist (1)
leefstijl (1)
leukemia (3)
leukemic stem cells (2)
LifeLines (2)
lifestyle (3)
liposomes (1)
lipotoxicity (1)
liver (3)
liver cancer (1)
liver disease (5)
liver diseases (1)
liver failure (1)
liver fibrosis (1)
liver metastases (1)
liver resection (1)
liver transplantation (9)
livercirrhosis (1)
locally advanced rectal caner (1)
locomotion (1)
long-term survival (1)
lumg transplantation (1)
lung (4)
lung cancer (5)
Lung function (1)
lung mechanics (2)
lung nodules (2)
lung recruitment (1)
lung transplantation (4)
lymphoma (2)
lynch syndrome (1)
machine learning (Matlab/Rstudio) (1)
machine perfusion (2)
major depressive disorder (1)
mass spectrometry (2)
mast cells (1)
mastocytosis (3)
measurement tool (1)
mechanical ventilation (9)
medical comorbidity (1)
medical device (4)
medical education (3)
medical imaging (8)
medically unexplained symptoms (2)
medication (3)
Medication reviews (1)
medication safety (1)
medication treatment (1)
medicine (1)
melanoma (5)
Meningioma (1)
meno-pauze (1)
mental retardation (1)
metabolic diseases (5)
Metabolic signaling (1)
metabolic syndrome (3)
metabolism (3)
metabool syndroom (3)
metformin (1)
method development (2)
microbiome (1)
microbiota (3)
microcephaly (1)
Microglia (1)
microRNA (2)
Minimally invasive parathyroidectomy (1)
mitochondria (1)
MitraClip (1)
Mobile electrocardiogram devices (1)
Mobility (1)
Modus partus (1)
molecular biology (2)
molecular chaperones (1)
Molecular Fluorescence Guided Surgery (1)
molecular mechanisms (1)
molecular microbiology (1)
Molecular tumour board (1)
molecular typing (1)
Monoclonal antibodies (1)
monocytes (1)
mood disorders (1)
Motor development (2)
Mouse models (1)
movement disorders (3)
MRI (7)
MRI / CT (1)
MRI / magnetic resonance imaging (3)
MRI brain (1)
MRS (1)
mucus clearance (1)
multi-morbidity (1)
Multi-organ failure (1)
Multi-phase CT (1)
multidrug resistance (1)
Multimorbidity (3)
multiple myeloma (2)
multiple sclerosis (3)
Musculoskeletal pain (1)
Music (1)
music intervention (1)
mutations (2)
myelin (1)
myocardial infarction (2)
myoclonus (1)
myoclonus dystonia (1)
NASH (1)
nasopharyngeal carcinoma (1)
Necrotische Enterocolitis (1)
necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
Neglected Tropical Diseases (1)
neoadjuvant chemoradiotherapy (1)
Neonatal growth (1)
neonatal hypoglycemia (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
Neonatal outcome (1)
neonates (2)
neonatology (1)
nephrology (2)
neuro-endocrine tumors (1)
neurobiology (1)
neurocognition (1)
neurodegeneration (4)
neurodegenerative diseases (3)
neurodevelopmental impairment (1)
neurodevelopmental outcome (1)
neuroendocrine tumor (1)
Neuroimaging (3)
neuroinflammation (1)
neurological development (1)
neurology (1)
neuromuscular blockade (1)
neuropathic pain (1)
neuropathy (1)
neuropsychiatric symptoms (1)
Neurosurgery (1)
neurotransmitters (1)
neutropenia (1)
new genes (1)
nier (1)
non-Hodgkin's disease (1)
Non-invasive ventilation (2)
Non-motor symptoms (2)
Noordzeeziekte (1)
nuclear receptors (1)
nursing home (1)
Nursing home residentss (1)
nutrient addiction (1)
nutrition (8)
obesity (6)
Occupational exposures (1)
Occupational health (1)
Older adults (1)
oligodendrocytes (1)
oncological epidemiology (2)
oncology (5)
oncoplastic surgery (1)
ongeplande heropname (1)
online wearables (1)
operative surgical procedure (1)
opthalmologic problems (1)
organ preservation (3)
organ transplant (1)
organ transplantation (2)
orthopedics (3)
osteomyelitis (1)
otolaryngology (1)
Ouderen (1)
outcome (1)
outcome and cognition (1)
Outcome Assessment (1)
Outcome measurement (5)
Outcomes (2)
ovarian cancer (3)
Overactieve blaas (2)
overweight (2)
Overweight/obesity (1)
oxidative stress (2)
oxygenation (1)
pain (2)
PALB2 mutation (1)
palliatief (1)
Palliatieve zorg (3)
palliative care (1)
pancreatic resection (1)
pancreatoduodenectomie (1)
parental support (1)
Parkinson disease (4)
Parkinson's disease (4)
Parkinson's disease (2)
Parkinson’s disease (1)
Parkinson's disease (4)
Participation restriction (1)
pathological complete response (1)
pathology (1)
pathway analysis (1)
Patiënt-gerichtheid (1)
patient centered care (1)
patient experiences (2)
Patient perspective (1)
patient related research (1)
patient satisfaction (1)
Patient-Reported-Outcomes (1)
PD-L1 immunohistochemistry (1)
pediatric cardiology (2)
Pediatric gastroenterology (1)
Pediatric rehabilitation (1)
pediatrics (6)
Percutane Nefro-Litholapaxy (2)
Percutaneous coronary intervention (PCI) (1)
Percutaneous intervention (2)
Peri-Acetabular Osteotomy (PAO) or Bernese/Ganz osteotomy (1)
perinatal care and psychiatry (1)
perineal wound healing (1)
periodontitis (1)
perioperative care (1)
Periprosthetic joint infection (1)
peritonitis (1)
Persistent somatic symptoms (1)
personal medicine (1)
personalized (1)
Personalized medicine (3)
PET (4)
pet scintigraphy (1)
PET-tracer (1)
Peyronie disease (1)
pharmacodynamics (1)
pharmacokinetics (1)
pharmacology (4)
Phelan-McDermid syndrome (1)
phenomenology (1)
phenotype-genotype study (1)
phenylketonuria (1)
photometry (1)
physical activity (3)
physical and mental functioning (1)
physical therapy (1)
physiology (2)
placenta (1)
plasmacytoma (1)
plastic surgery (1)
platelet (1)
polisomnography (1)
Polycomb (1)
polypharmacy (6)
population screening (2)
portal hypertension (1)
Positron Emission Tomography (1)
Postgraduate Medical Education (2)
postoperative complications (2)
postoperative outcome (1)
postoperative pain (1)
posttraumatic (1)
postural control (1)
potassium (1)
pre-clinical imaging (1)
pre-peritoneal wound catheters (1)
Precision medicine (1)
predictiemodel (1)
Predictiemodellen (1)
prediction (1)
prediction modeling (2)
preeclampsia (1)
pregnancy (11)
Prematuren (1)
prenatal diagnosis (2)
prenatal diagnostics (2)
prenatal programming (1)
preservation fluids (1)
preterm (1)
preterm birth (1)
Prevalence of cancer (1)
prevention (4)
preventive cardiovascular medication (1)
primairy health care (1)
primary care (7)
primary care, gastro-enteritis, children, out-of-hours service, pediatrics. (2)
Primary Hyperparathyroidism (1)
probiotics (1)
Proefschrift (1)
prognosis (2)
Prolapse surgery (1)
proliferation (1)
Promoveren (1)
prospective cohort study (1)
prostate cancer (1)
Prosthetic Valve (1)
protein aggregation (1)
protein kinase inhibitors (1)
protein restoration therapy (1)
proteomics (3)
prothrombin complex concentrate (1)
PSMA PET/CT (1)
Psychiatric symptoms (1)
psychiatry (1)
psychiatry, high-field MRI (1)
Psychology (1)
psychosis (1)
psychosocial (2)
psychosocial and lifestyle determinants (1)
psychotherapy (1)
Publiceren (1)
pulmonary embolism (1)
pulmonary hypertension (1)
pulmonary rehabilitaion (1)
Pulmonary rehabilitation (1)
QST (1)
qualitative research (4)
quality of life (7)
quality of reduction (1)
Quantification (1)
quantitative sensory testing (1)
questionnaire (3)
questionnaire research (1)
Radiology (11)
radiotherapy (31)
Randomized comparative trial (1)
randomized controlled trial (1)
raynaud (1)
RCT (1)
real world dosing (1)
Recommendation (1)
recovery (1)
rectal cancer (2)
rectum carcinoma (1)
referral (1)
Refugee women (1)
refugees (1)
regeneration (3)
rehabilitation (5)
Relatives (1)
Renal cell carcinoma (1)
renal disease (2)
renal transplantation (1)
renal tubular epithelium (1)
reperfusion (2)
Reproducibility of Results (1)
Reproduction (1)
reproductive health (1)
reproductive immunology (2)
respiratory failure (1)
respiratory viruses (1)
restoration (1)
retina (2)
retinal physiology (1)
retrospective (1)
revision surgery (1)
rheologic and oxygen transport capacity (1)
risk factors (2)
RNA (1)
Robot-assisted surgery (1)
ROC curve (1)
running (1)
saliva (1)
SARS-CoV-2 vaccination (1)
Schildklierkanker (1)
schizophrenia (2)
screening (1)
Screening tools (3)
Seating devices (1)
Second opinion (1)
Selective Internal Radiotherapy (1)
Self - Determination Theory (1)
self-management (1)
self-renewal (2)
sensitisatie van het centraal zenuwstelsel (1)
Sentinel lymph node (1)
Sepsis (2)
serious gaming (1)
severe mental disorders (1)
sex-specific (1)
shared decision making (1)
shear wave ultrasound (1)
signal transduction (1)
Single Nucleotide Polymorphisms (SNP) (1)
siRNA (1)
Sjogren's syndrome (1)
Sjögren's syndrome (1)
skeletal muscle mass (1)
Skin cancer (3)
SLE (2)
Sleep (1)
small for gestational age (1)
small molecular drugs (1)
Social media (1)
soft tissue sarcoma (2)
spataderen (1)
spectroscopy (1)
Spine surgery (1)
sport (1)
sport medicine (1)
sports injury (1)
Stage wetenschap / research project (1)
statistics (1)
steatosis hepatis (1)
Stem cell division (2)
stem cells (4)
stenose (1)
stoma (1)
Streptococcus pneumoniae (2)
stress (4)
stroke (2)
Stuitbevalling (1)
stuitpijn (1)
subarachnoid hemorrhage (1)
surgery (7)
surgery induced muscle loss (1)
surgical oncology (2)
surgical resection (1)
surgical treatment (3)
survey (2)
survival (2)
survival, Epstein-Barr virus (1)
Survivor care (3)
synaptic density (1)
syndrome (1)
Systematic Review (3)
systemische sclerose (1)
systems biology (1)
T cell genes (1)
TARC (1)
target organ injury (1)
teeth restoration (1)
teleconsultatie (1)
telemonitoring (1)
tendinopathy (1)
therapy compliance (1)
therapy resistance (1)
Thiosulphate sulfurtransferase activation (1)
thoracic endovascular aortic repair (1)
thoracic irradiation (1)
thrombolysis (1)
thrombosis (5)
Thyroid cancer (1)
thyroid gland (1)
time alignment (1)
TIPS (1)
TNF (1)
tolerance induction (1)
tolvaptan (1)
total hip arthroplasty (2)
total knee arthroplasty (1)
Toxicities (1)
Transanal TME (1)
transcatheter aortic valve implantation (1)
transcraniëel Doppler onderzoek (TCD) (1)
Transcranial Magnetic Stimulation (2)
transcription factor (1)
transcriptional regulation (2)
translation validation (1)
translational (4)
transplant rejection (1)
transplantatation (1)
Transplantatie (1)
transplantation (33)
Transplantation surgery (1)
TransplantLines (1)
transport proteins (1)
Transpulmonary pressure (1)
traumachirurgie (1)
traumatic brain injury (2)
traumatisch hersenletsel (1)
Treatment (3)
Treatment goals (1)
Treatment response (1)
tremor (1)
tricyclic antidepressants (1)
triglyceride (1)
trombose (1)
tropical medicine (1)
TSST (1)
Tuberculosis (1)
type 2 diabetes (2)
tyrosinemia (1)
uitdroging (1)
uitkomst (1)
ulcerative colitis (5)
ultrasound (4)
underrepresentation women (1)
upper extremity (2)
urinary tract infection (2)
Urolithiasis (3)
vaatmetingen (1)
vaccine (2)
Validation study (2)
vascular graft infection (1)
vascular medicine (4)
vascular surgery (3)
vasculitis (1)
venous thrombosis (4)
Ventilator induced lung injury (2)
Verteporfin (1)
vesicular trafficking (1)
vestibular dysfunction (1)
Virtual Reality (4)
virus (2)
visual field testing (1)
visual neuroscience (1)
vitamin D (1)
vitamin D deficiency (1)
vitamin K antagonists (1)
voetletsel (1)
volumetry (1)
Von Hippel-Lindau (1)
waiting list (1)
Weaning (1)
Wegener's granulomatosis (2)
West Africa (1)
whole exome sequencing (1)
Wnt signaling (1)
Work capacity evaluation (1)
Work of breathing (1)
X-rays (1)
young patients (1)
zebrafish (2)
Zelfbeoordelingslijst (1)
zuurstofsaturatie (1)
Beyond the borders of motor symptoms: Quality of life and non-motor symptoms in patients with movement disorders
Keywords: quality of life
movement disorders
Non-motor symptoms
Researchers:
prof. dr. M.A.J. de Koning-Tijssen
dr. T.J. de Koning
drs. E.R. Timmers
S.S. Polet
Nature of the research:
Retrospective cohort study with data from various groups of patients with movement disorders
Fields of study:
neurology
Background / introduction
Movement disorders can involve an excess of movement (hyperkinetic movement disorders, e.g. myoclonus, tremor), a paucity of movement (hypokinetic movement disorders, e.g. parkinsonism), or having problems with coordination of movement (ataxia).
This research project will specifically focus on hyperkinetic movement disorders with various etiologies involved, including metabolic disorders. Within the field of movement disorders, still little is known about the presence of non-motor symptoms (e.g. depression, anxiety, sleep, pain) and the quality of life in patients.
The project will be embedded in the national and European expertise center Movement Disorders Groningen (www.movementdisordersgroningen.com) and the research line of Prof. Marina AJ de Koning-Tijssen.
Research question / problem definition
1. What is the degree of non-motor symptoms and quality of life in different groups of patients with movement disorders, and how do those groups differ?
2. Which questionnaires are used most frequently in clinical practice and how are the questions in the non-motor questionnaires influenced by the motor symptoms of the patients?
Workplan
During the past years we have collected data from different groups of patients with hyperkinetic movement disorders. These data include both the motor symptoms but also the non-motor symptoms. We want to fuse all the data and compare the degree of non-motor symptoms and quality of life among these groups of patients, and will also relate this to to their motor symptoms.
During the project an overview will be made of the questionnaires that are used by researchers in the expertise centre. The student will analyse the data and focus on which questionnaires are influenced by the motor scores (e.g. asking for anxiety includes questions like : do you tremble when you are scared? Patients with tremor always tremble so this is an inappropriate question). The student will enquire which problems are encountered when using those questionnaires. In addition, based on this problems a literature search is performed to make additional recommendations for questionnaires to be used in clinical practice.
We are looking for an student writing his/her master thesis (stage wetenschap) who is interested in the field of neurology. The student will be able to join activities at the department such as weekly research meetings in which current research is presented and where advise can be asked within the research group.
References
Zutt R, Smit M, Zijl van J, Gelauff J, Stone J, Tijssen MAJ. The presence of depression and anxiety do not distinguish between functional jerks and cortical myoclonus. Parkinsonism and Related Disorders 2017; 45: 90-93.
Timmers ER, Smit M, Kuiper A, Bartels AL, Veen van der S, Stouwe van der MMA, Santens P, Bergmans B, Tijssen MAJ. Myoclonus-dystonia: Distinctive motor and non-motor phenotype from other dystonia syndromes. Parkinsonism and Related Disorders 2019; 69: 85-90.