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allergology (9)
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epidemiology and statistics (20)
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haematology (25)
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health sciences (22)
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intensive care (28)
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laboratory medicine (8)
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medical education (6)
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microbiology (23)
molecular biology (34)
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movement sciences (15)
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obstetrics (4)
oncology (77)
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Patient Related Research (10)
pediatrics (83)
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Stamcelbiologie (3)
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surgery (94)
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urology (10)
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(Epi)genetic epidemiology (1)
(medical)genetics (5)
5jaars overleving (1)
:psychosocial and lifestyle determinants (4)
aanhoudende lichamelijke klachten (ALK) (1)
abdomen (1)
access to medicine (1)
ACE-inhibitor (1)
Acetabular fracture (1)
Acetylcholine (1)
Achilles tendinopathy (1)
Achilles tendinopatie (1)
ACS-NSQIP surgical risk calculator (1)
activated clotting time (1)
Acute flaccid myelitis (1)
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Acute Myeloid Leukemia (1)
acute myocardial infarction (2)
adpkd (3)
Advanced cell culture (1)
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adverse side effects (1)
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ageing (4)
ageing lungs (1)
Ageing, Nuclear Envelope, Nuclear Pore Complex (1)
aging (1)
airway epithelium (1)
Alcohol (3)
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Allergic asthma (1)
Allergologie (1)
Allergy (1)
allogene stam cel transplantatie (2)
Allogeneic stem cell transplantation (1)
Amalgaam (2)
ambulance (1)
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ANCA associated vasculitis (1)
anesthesia (5)
Anesthesiologie (1)
anesthesiology (2)
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Animal research (2)
ankylosing spondylitis (2)
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antibiotics (3)
anticoagulants (2)
antidepressants (4)
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anxiety (1)
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aortic stenosis (1)
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Appendicitis (2)
arrhythmia (1)
arterioveneuze fistel, dialyse shunt (1)
Artificial Intelligence (3)
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asthma (7)
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astma (1)
asylum seekers (1)
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atherosclerosis (3)
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autoimmune blistering diseases (1)
autoimmune disease (6)
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Autophagy (2)
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beta cell destruction (1)
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biofilm (1)
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brain (3)
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brain tumour (2)
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Breast augmentation mammoplasty (2)
breast cancer (5)
breast conserving surgery (1)
Breast implants (1)
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bronchial epithelium (1)
built environment (1)
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Calorie restriction (1)
Calprotectin (2)
cancer (30)
cancer cell apoptosis (1)
Cancer cell metabolism (1)
cancer cells (1)
cancer patients (2)
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Cardiac Amyloidosis (2)
cardiac differentiation (1)
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cardiac output (1)
cardiac surgery (1)
cardio-pulmonary toxicity (1)
cardiogenetics (2)
cardiology (10)
cardiometabolic health (1)
cardiopulmonary bypass (1)
Cardiovasculaire effecten (1)
cardiovascular (4)
cardiovascular disease (6)
cardiovascular risk (1)
cardiovascular risk management (1)
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caries (1)
carriers (1)
cartilage (2)
Catheterization lab (1)
celiac disease (4)
cell biology (1)
cell cycle (2)
cell death (3)
cell saver (1)
cellbiology (1)
cellular interactions (1)
Central Sensitization (nociplasticity) (1)
cerebral palsy (1)
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Cervical spine (2)
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child (2)
Child development (1)
child outcome (2)
childbirth (1)
children (9)
ChIP assay (1)
cholangiocyte (1)
cholestasis (1)
cholesterol fluxes (1)
chromosome (1)
chronic depression (2)
chronic disease (2)
Chronic Kidney Disease (5)
chronic lung allograft dysfunction (1)
Chronic rhinosinusitis (1)
chronic ventilatory support (1)
Chronische pijn (2)
Circadian rhythmicity (1)
cirrhosis (2)
Clinical decision making (1)
clinical decision-making (1)
clinical diagnostics (4)
clinical epidemiology (1)
clinical genetics (1)
Clinical retrospective patient outcome study (1)
Clinical Severity Score (1)
co-morbidity (1)
coagulation (1)
coating (1)
coccygodynie (1)
cochlear implant users (1)
Cognition (1)
cognition and outcome (2)
cognitive decline (1)
cognitive function (3)
cognitive impairment (1)
cognitive testing (1)
collect clinical information (1)
Colon carcinoma (1)
colonisation (1)
colorectal cancer (2)
colorectal cancer, CEA value, CT-scan, follow up (1)
colorectal surgery (3)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (1)
competency development (1)
complement (3)
complex congenital heart disease (1)
compliance (1)
complications (4)
Comprehensice geriatric assessment (1)
computed tomography (CT) (3)
Congenital anomalies (1)
congenital heart disease (3)
connective tissue disease (1)
Constipation (1)
continue glucose monitoring (1)
contraction (1)
contrastmiddel (1)
COPD (14)
Coronair angiografie (1)
coronary arteries (1)
coronary artery bypass grafting (1)
Coronary Artery Disease (3)
cosmetic outcome (1)
costs (3)
cough (1)
COVID-19 (6)
craniopharyngioma (2)
Craniotomy (1)
Critically ill children (3)
Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
CT (1)
CT imaging (2)
CT-scan (1)
cystic fibrosis (4)
cytokines (1)
Damage (1)
database (3)
database registry (1)
Deep brain stimulation (DBS) (6)
deletion (2)
delirium (1)
delivery agent (1)
dementia (3)
dental erosion (1)
dental hygiene (1)
dentist (1)
Deprescribing (1)
depression (4)
Depression, (2)
Depression, translational neuroscience (1)
dermatology (3)
Descriptive and retrospective study with clinical results (1)
development (3)
Developmental coordination disorder (1)
developmental disorder (1)
developmental disorders (1)
Developmental Dysplasia of the Hip (DDH) (2)
developmental psychopathology (1)
Dexamethasone (1)
diabetes (3)
Diabetes mellitus (4)
diabetis (1)
diagnostic importance (1)
diagnostic test (1)
diagnostics (3)
dialysis (3)
Diaphragm paralysis (1)
Diet (2)
dilated cardiomyopathy (1)
disease activity (1)
disease models (1)
Disease modifying therapy (1)
DNA (1)
DNA damage (1)
DNA damage response (1)
DNA methylation signatures (1)
donor (1)
Drosophila (2)
drug delivery (1)
Drug Interactions (1)
dry eye (2)
duplication (1)
Dupuytren's disease (1)
Dupuytren's disease (1)
Dystonia (6)
e-health (5)
early detection (1)
early life experiences (1)
Early Onset Ataxia (2)
eating disorders (1)
echo duplex, diagnotische waarde (1)
echocardiography (2)
eco-anxiety (1)
Education (2)
EEG-EMG (1)
effects (1)
Ehealth (10)
Elder (1)
elderly (6)
elderly cancer patients (1)
elderly patients (2)
electroconvulsive therapy (1)
Electronic Nose (1)
EMG (2)
EMG-analysis (1)
emphysema (1)
EMSA (1)
enamel (1)
end-expiratory lung volume (1)
endocrine disrupting chemicals (1)
endocrine therapy (1)
endocrinology (1)
endometriosis (1)
Endophenotypes (1)
Endothelial Cell (2)
endothelial cells (1)
endoveneuze laser behandeling (1)
energy metabolism (3)
engineering (1)
enkelletsel (1)
eNose (1)
epidemiology (9)
epidermolysis bullosa (2)
epigenetics (4)
epithelial cells (1)
epithelial disorders (1)
ercp (1)
errors (1)
erythropoietin (1)
Esophageal cancer (1)
esophageal carcinoma (2)
Esophageal pressure (1)
esophagus surgery (2)
Essential tremor (3)
ESWL (2)
ethics (1)
evidence-based medicine (1)
EVLT (1)
Ex vivo lung perfussion (1)
exercise testing (1)
exercise therapy (1)
Exercise training (1)
Exergames (1)
exome sequencing (3)
Faecalibacterium prausnitzii (1)
familial hypercholesterolemia (1)
Family history (2)
Farmacologie (1)
farmacology (1)
fatigue (4)
fatty acids (1)
fatty liver disease (1)
FDG PET/CT (2)
fecal incontinence (1)
fertility (1)
fetal gender (1)
fibrosis (3)
filling (2)
First Episode Psychosis (2)
first trimester anomaly scan (1)
first trimester ultrasound (1)
fitness (1)
fluid administration, hemodynamic monitoring (1)
fluid management (1)
Fluorescence imaging (1)
fMRI (1)
fNIRS-monitoring (1)
foot ulcers (1)
frailty (3)
Frailty screening (2)
Function Endoscopic Sinus Surgery (1)
functional genetics (2)
functional somatic symptoms (1)
Functional stroke mimic (1)
functionele symptomen (1)
Fungal Infections (1)
fysiotherapie (1)
gait (1)
galectin-3 (1)
Galgangatresie (1)
game (1)
gangliosides (1)
GBA1-gene (1)
GECKO (1)
Gender (1)
gene enrichment (1)
gene expression (1)
gene regulation (1)
general movements (1)
general practice (3)
general practitioner (1)
genetic diseases (1)
Genetic sequencing (1)
genetic testing (1)
genetics (5)
genome analysis (1)
genomic instability (1)
genotype-phenotype correlation (1)
geriatric oncology (1)
geriatrics (2)
glaucoma (2)
Glioblastoma (1)
Gliomas (1)
global child health (1)
global health (2)
Glomerular filtration rate (1)
Glucocorticoids (1)
glucose homeostasis (1)
growth hormone deficiency (1)
Guidelines (2)
Guillain-Barré syndrome (1)
Gunanine Nucleotide Exchange Factor (1)
Gut Microbiota Composition (2)
gut-liver acis (1)
haemophilia (2)
hand (1)
Head and neck cancer (5)
Health care professionals (1)
Health care utilization (1)
health economics (3)
Health indicators (1)
Health literacy (1)
Health Related Quality of Life (1)
health-related quality of life (4)
healthcare education (1)
healthcare transformation (1)
hearing impairment (1)
hearing rehabilitation (1)
heart (14)
heart failure (7)
Heart rate variability (1)
heart transplantation (1)
heart valve replacement (1)
heat shock proteins (1)
Heel prick Screening (1)
hematology, cancer, critical care, outcome (3)
hematopoiesis (5)
hemodynamic monitoring (2)
hemodynamics (1)
hemostasis (2)
heparin induced thrombocytopenia (1)
hepatitis (2)
hepatocellular carcinoma (1)
hereditary cancer (1)
hereditary kidney disease (1)
HFOV (2)
Hibernation (4)
Hidradenitis suppurativa (1)
hip (1)
hip and knee prothesis (2)
Hip artroplasty (1)
Historical controls (1)
HIV (3)
Hodgkin lymphoma (2)
Home mechanical ventilation (3)
Honours education (1)
hormone receptors (1)
HPB surgery (1)
huisarts (1)
Huisartsgeneeskunde (1)
human genetics (1)
human hematopoietic stem cells (3)
Humeral Fractures (1)
hydrochlorothiazide (1)
hydrogen sulfide (1)
hymenoptera venom allergy (1)
hyperglycaemia (1)
Hyperkinetic movement disorders (2)
Hypertensie (1)
hypoglycemia (1)
hypophospatemic rickets (1)
hypoplastic left heart syndrome (1)
hypotension (1)
IBD (4)
IGF-1 (1)
image biomarker (2)
imaging (12)
imaging, biomarkers (1)
Immune checkpoint inhibitors (3)
immune response (1)
immune suppression (1)
Immune-related adverse events (1)
immunity (1)
immunology (10)
immunosuppression (1)
immunotherapy (4)
impact (1)
implant infection (2)
in vitro (1)
in vitro fertilization (1)
Inborn Error of Metabolism (1)
incidence (1)
incontinence (2)
individualised treatment (1)
infant (2)
infant assessment (2)
infant development (3)
Infant Stool Colour Card (1)
infection (3)
Infection and inflammation (1)
Infectious diseases (1)
Infective Endocarditis (1)
inflammation (5)
Inflammatory bowel disease (3)
Inflammatory rheumatic disease (3)
Informatie-uitwisseling (1)
Information technology (1)
Inguinal Hernia Surgery (1)
innovatie van zorg (2)
insulin (1)
insulitis (1)
Integrative care (1)
intellectual disability (1)
Intensive care (1)
interactie (1)
interprofessional education (1)
Interviews (1)
Interviewstudie (1)
intestinal disease (2)
intestinal disorder (1)
intestinal integrity (1)
intestinal transplantation (2)
Intestinal wall permeability (1)
intestine (1)
Intracraniele druk (1)
Intraoperative neurophysiology (1)
IONM (1)
iPSC (1)
iron deficiency (2)
ischemia (3)
ischemia-reperfusion injury (1)
ischemia/reperfusion injury (2)
ischemic stroke (2)
Isolation (1)
isotopes (1)
IVF (3)
jaundice (2)
joint (2)
Ki67 proliferation index (1)
kidney (6)
kidney disease (5)
Kidney Donation (3)
kidney transplantation (13)
kidneydonor (1)
Kindergeneeskunde (1)
kinetic modeling (1)
Klinische onderzoeksstage (1)
knockout mouse (1)
kwaliteit van leven (2)
kwaliteit van zorg (1)
laboratory animals (10)
language development (1)
language screening (1)
laparoscopy (1)
laryngectomy (3)
late effects of treatment (1)
Leadership (1)
learning curve sonologist (1)
learning organization (1)
leefstijl (1)
leukemia (3)
leukemic stem cells (2)
LifeLines (2)
lifestyle (4)
liposomes (1)
lipotoxicity (1)
liver (3)
liver cancer (1)
liver disease (5)
liver diseases (1)
liver failure (1)
liver fibrosis (1)
liver metastases (1)
liver resection (1)
liver transplantation (10)
livercirrhosis (1)
locally advanced rectal caner (1)
locomotion (1)
long-term survival (1)
longitudinal (1)
lumg transplantation (1)
lung (4)
lung cancer (5)
Lung function (1)
lung mechanics (2)
lung nodules (2)
lung recruitment (1)
lung transplantation (5)
lymphoma (2)
lynch syndrome (1)
machine learning (Matlab/Rstudio) (1)
machine perfusion (2)
major depressive disorder (1)
mass spectrometry (2)
mast cells (1)
mastocytosis (3)
measurement tool (1)
mechanical ventilation (10)
medical comorbidity (1)
medical device (4)
medical education (2)
medical imaging (8)
medically unexplained symptoms (2)
medication (3)
Medication reviews (1)
medication safety (1)
medication treatment (1)
medicine (1)
melanoma (5)
Meningioma (2)
meno-pauze (1)
mental retardation (1)
metabolic diseases (5)
Metabolic signaling (1)
metabolic syndrome (3)
metabolism (3)
metabolites (1)
metabool syndroom (3)
metformin (1)
method development (2)
microbiome (1)
microbiota (3)
microcephaly (1)
Microglia (1)
microRNA (2)
Minimally invasive parathyroidectomy (1)
mitochondria (1)
MitraClip (1)
Mobile electrocardiogram devices (1)
Mobility (1)
molecular biology (2)
molecular chaperones (1)
Molecular Fluorescence Guided Surgery (1)
molecular mechanisms (1)
molecular microbiology (1)
Molecular tumour board (1)
molecular typing (1)
Monoclonal antibodies (1)
monocytes (1)
mood disorders (1)
Motor development (2)
Mouse models (1)
movement disorders (3)
MRI (8)
MRI / CT (1)
MRI / magnetic resonance imaging (3)
MRI brain (1)
MRS (1)
mucosal melanoma (1)
mucus clearance (1)
multi-morbidity (1)
Multi-organ failure (1)
Multi-phase CT (1)
multidrug resistance (1)
Multimorbidity (3)
multiple myeloma (2)
multiple sclerosis (4)
Musculoskeletal pain (1)
Music (1)
music intervention (1)
music therapy (4)
mutations (2)
myelin (1)
myocardial infarction (2)
myoclonus (1)
myoclonus dystonia (1)
NASH (1)
nasopharyngeal carcinoma (1)
Necrotische Enterocolitis (1)
necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
Neglected Tropical Diseases (1)
neoadjuvant chemoradiotherapy (1)
neonatal hypoglycemia (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
Neonatal outcome (1)
neonatale icterus (1)
neonates (2)
neonatology (1)
nephrology (2)
neuro-endocrine tumors (1)
neurobiology (1)
neurocognition (1)
neurodegeneration (4)
neurodegenerative diseases (3)
neurodevelopmental impairment (1)
neurodevelopmental outcome (1)
neuroendocrine tumor (1)
Neuroimaging (5)
neuroinflammation (1)
neurological development (1)
neurology (1)
neuromuscular blockade (1)
neuropathic pain (1)
neuropathy (1)
neuropsychiatric symptoms (1)
Neurosurgery (4)
neurotransmitters (1)
neutropenia (1)
new genes (1)
nier (1)
non-Hodgkin's disease (1)
Non-invasive ventilation (2)
Non-motor symptoms (2)
Noordzeeziekte (1)
Nuclear Medicine (1)
nuclear receptors (1)
nursing home (1)
Nursing home residentss (1)
nutrient addiction (1)
nutrition (8)
obesity (6)
Occupational exposures (1)
Occupational health (1)
Older adults (1)
oligodendrocytes (1)
oncological epidemiology (1)
oncology (6)
oncoplastic surgery (1)
ongeplande heropname (1)
online wearables (1)
opthalmologic problems (1)
organ preservation (3)
organ transplant (1)
organ transplantation (2)
orthopedics (3)
osteomyelitis (1)
otolaryngology (1)
Ouderen (1)
outcome (2)
outcome and cognition (1)
Outcome Assessment (1)
Outcome measurement (4)
Outcomes (2)
Outocome (1)
ovarian cancer (1)
Overactieve blaas (2)
overweight (2)
Overweight/obesity (1)
oxidative stress (2)
oxygenation (1)
pain (2)
Pain (Chronic) (1)
PALB2 mutation (1)
palliatief (1)
Palliatieve zorg (3)
palliative care (1)
pancreatic resection (1)
pancreatoduodenectomie (1)
paralysis (1)
parental support (1)
Parkinson disease (4)
Parkinson's disease (4)
Parkinson's disease (2)
Parkinson’s disease (1)
Parkinson's disease (4)
Participation restriction (1)
pathological complete response (1)
pathology (1)
pathway analysis (1)
Patiënt-gerichtheid (1)
patient centered care (1)
patient experiences (2)
Patient perspective (1)
patient related research (1)
patient satisfaction (1)
Patient-Reported-Outcomes (1)
PD-L1 immunohistochemistry (1)
pediatric cardiology (2)
Pediatric gastroenterology (1)
Pediatric rehabilitation (1)
pediatrics (6)
Percutane Nefro-Litholapaxy (2)
Percutaneous coronary intervention (PCI) (1)
Percutaneous intervention (2)
Peri-Acetabular Osteotomy (PAO) or Bernese/Ganz osteotomy (2)
perinatal care and psychiatry (1)
perineal wound healing (1)
periodontitis (1)
perioperative care (1)
Periprosthetic joint infection (1)
peritonitis (1)
Persistent somatic symptoms (1)
personal medicine (1)
personalized (1)
Personalized medicine (3)
personalized treatment (1)
PET (6)
pet scintigraphy (1)
PET-tracer (1)
Peyronie disease (1)
pharmacodynamics (1)
pharmacokinetics (1)
pharmacology (4)
Phelan-McDermid syndrome (1)
phenomenology (1)
phenotype-genotype study (1)
phenylketonuria (1)
photometry (1)
physical activity (3)
physical and mental functioning (1)
physical therapy (1)
physiology (2)
placenta (1)
plasmacytoma (1)
plastic surgery (1)
platelet (1)
polisomnography (1)
Polycomb (1)
polypharmacy (7)
population cohort study (1)
population screening (2)
portal hypertension (1)
Positron Emission Tomography (1)
Postgraduate Medical Education (2)
postoperative complications (2)
postoperative outcome (1)
postoperative pain (1)
posttraumatic (1)
postural control (1)
potassium (1)
pre-clinical imaging (1)
Precision medicine (1)
predictiemodel (1)
Predictiemodellen (1)
prediction (1)
prediction modeling (2)
pregnancy (8)
Prehabilitation (1)
Prematuren (1)
prenatal diagnosis (1)
prenatal diagnostics (2)
prenatal programming (1)
preservation fluids (1)
preterm (1)
preterm birth (1)
Prevalence of cancer (1)
prevention (3)
preventive cardiovascular medication (1)
primairy health care (1)
primary care (7)
primary care, gastro-enteritis, children, out-of-hours service, pediatrics. (2)
Primary Hyperparathyroidism (1)
probiotics (1)
Proefschrift (1)
prognosis (3)
Prolapse surgery (1)
proliferation (1)
Promoveren (1)
prospective cohort study (1)
prostate cancer (1)
Prosthetic Valve (1)
protein aggregation (1)
protein kinase inhibitors (1)
protein restoration therapy (1)
proteomics (3)
prothrombin complex concentrate (1)
PSMA PET/CT (1)
Psychiatric symptoms (1)
psychiatry (1)
psychiatry, high-field MRI (1)
psychological stress (1)
Psychology (1)
psychosis (1)
psychosocial (2)
psychosocial and lifestyle determinants (1)
psychotherapy (1)
Publiceren (1)
pulmonary embolism (1)
pulmonary hypertension (2)
pulmonary rehabilitaion (1)
Pulmonary rehabilitation (1)
QST (1)
qualitative research (3)
quality improvement (1)
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Background / introduction
Oxidative stress is characterized by increased production of reactive oxygen species (ROS) and decreased antioxidant defense and plays a pivotal role in a variety of human diseases. (1) Generally, oxidative stress is considered as a major disease mechanism responsible for extensive cellular and molecular damage, perpetuation of inflammatory reactions and tissue destruction.
An example of such a disease affected by oxidative stress is inflammatory bowel disease (IBD). (2) IBD is an umbrella term used to describe two main entities: Crohn’s disease (CD) and ulcerative colitis (UC). IBD has a multifactorial disease origin, with a complex interplay between genetics, gut microbiota, the host immune system and lifestyle factors. Patients with IBD typically show a relapse-remitting disease course that is difficult to predict and adequately treat. Nowadays, an invasive endoscopic procedure is the gold standard diagnostic modality to determine IBD disease activity, however, this investigation is accompanied by poor patient acceptance, risk of complications and high costs. For this reason, a large area of research is focused on the discovery of novel biomarkers for inflammatory disease activity in IBD.
Recently, we have investigated serum free thiols (R-SH, sulfhydryl groups) as biomarker for IBD disease activity and found favorable associations with several disease activity markers. (3-4) Free thiols are considered a robust and reliable read-out of systemic levels of oxidative stress. Typically, systemic oxidative stress is associated with decreased free thiol levels, whereas high levels of free thiols are representative of a favorable redox status. (1) In addition, there have been other studies that focused on free thiols as potential biomarker, though in different diseases. For instance, a study in renal transplant recipients investigated serum free thiols and found free thiol levels to be associated with improved patient and graft survival. (5) Another study demonstrated favorable associations of serum free thiols with markers of severity and prognosis of heart failure. (6)
Overall, these results indicate that a simple measurement of total serum thiol status may be highly useful for measuring systemic oxidative stress and may act as potentially predictive tool in future translational research. Since serum free thiols can also be therapeutically modulated, they form a potential target for therapy, which makes them even more interesting and valuable to study.
Research question / problem definition
In this research, we have several questions that we would like to answer:
What is the role of serum free thiols in diseases affected by oxidative stress?
What is the value of serum free thiols as biomarker for disease activity in IBD and related disorders?
What are the effects of therapeutic interventions on systemic oxidative stress?
What is the predictive capacity of serum free thiols regarding response to therapy and disease prognosis?
Workplan
The student will help to discover the possible roles of free thiol status in IBD and other diseases affected by oxidative stress. A large amount of data has already been collected that has to be explored to be able to assess free thiol status as potentially predictive tool for disease-specific outcomes and prognosis. These studies will be clinically-oriented and of translational origin, and an easy shift could be made towards more fundamental research (if preferred). The student will learn a lot about disease mechanisms and develop skills for data analysis and data interpretation.
References
(1) Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, et al. The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine. Antiox Redox Signal 2017;27(10):684-712.
(2) Pereira C, Grácio D, Teixeira JP, Magro F. Oxidative Stress and DNA Damage: Implications in Inflammatory Bowel Disease. Inflamm Bowel Dis 2015;21(10):2403-17.
(3) Bourgonje AR, von Martels JZH, Bulthuis MLC, van Londen M, Faber KN, Dijkstra G, van Goor H. Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress. Front Physiol 2019;10:499.
(4) Bourgonje AR, Gabriëls RY, de Borst MH, Bulthuis MLC, Faber KN, van Goor H, Dijkstra G. Serum Free Thiols Are Superior to Fecal Calprotectin in Reflecting Endoscopic Disease Activity in Inflammatory Bowel Disease. Antioxidants (Basel) 2019;8(9):351.
(5) Frenay AS, de Borst MH, Bachtler M, Tschopp N, Keyzer CA, van den Berg E, Bakker SJL, Feelisch M, Pasch A, van Goor H. Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients. Free Radic Biol Med 2016;99:345-51.
(6) Koning AM, Meijers WC, Pasch A, Leuvenink HGD, Frenay AS, Dekker MM, Feelisch M, de Boer RA, van Goor H. Serum free thiols in chronic heart failure. Pharmacol Res 2016;111:452-58.