Project details
Choose a field of study
allergology (9)
anesthesiology (30)
biomaterials (12)
cardiology (36)
cardiology and thoracic surgery (14)
cell biology (47)
child and adolescent psychiatry (1)
dentistry (4)
dermatology (10)
diabetes (7)
endocrinology (12)
ENT medicine (10)
epidemiology (56)
epidemiology and statistics (19)
gastroenterology (55)
general internal medicine (9)
genetics (43)
geriatrics (20)
GP medicine (40)
gynaecology (18)
haematology (25)
health psychology (17)
health sciences (23)
immunology (33)
intensive care (24)
internal medicine (36)
laboratory medicine (8)
mass spectrometry (3)
medical biology (18)
medical education (6)
medical physiology (7)
microbiology (23)
molecular biology (34)
molecular imaging (5)
movement sciences (15)
nephrology (40)
neurology (71)
neurosurgery (14)
nuclear medicine (19)
obstetrics (12)
obstetrics (9)
oncology (77)
ophthalmology (6)
orthopedics (17)
pathology (17)
Patient Related Research (8)
pediatrics (78)
pharmacology (28)
plastic surgery (5)
psychiatry (36)
pulmonology (41)
radiology (56)
radiotherapy (7)
rehabilitation (21)
reumatology (11)
Sociale Geneeskunde (14)
Sociale Psychiatrie (3)
sports medicine (5)
Stamcelbiologie (3)
Straling en Stresscelbiologie (1)
Stralingswetenschappen (3)
surgery (90)
traumatology (8)
tropical medicine (7)
urology (10)
vascular medicine (20)
virology (2)
or
Choose a keyword
(Epi)genetic epidemiology (1)
(medical)genetics (5)
5jaars overleving (1)
:psychosocial and lifestyle determinants (4)
abdomen (1)
access to medicine (1)
ACE-inhibitor (1)
Acetabular fracture (1)
Acetylcholine (1)
Achilles tendinopathy (1)
Achilles tendinopatie (1)
ACS-NSQIP surgical risk calculator (1)
activated clotting time (1)
Acute gastroenteritis (1)
Acute Myeloid Leukemia (1)
acute myocardial infarction (2)
adpkd (3)
Advanced cell culture (1)
Advanced imaging (1)
Advanced Microscopy (2)
adverse side effects (1)
Advice (1)
Africa (2)
ageing (4)
ageing lungs (1)
Ageing, Nuclear Envelope, Nuclear Pore Complex (1)
aging (1)
airway epithelium (1)
Alcohol (2)
Allergen immunotherapy (1)
Allergic asthma (1)
Allergologie (1)
Allergy (1)
allogene stam cel transplantatie (2)
Allogeneic stem cell transplantation (1)
Alternative for epidural analgesia (1)
Amalgaam (2)
ambulance (1)
Anaphylaxis (1)
ANCA associated vasculitis (1)
anesthesia (5)
Anesthesiologie (1)
anesthesiology (2)
angiogenesis (1)
animal models (1)
Animal research (2)
ankylosing spondylitis (2)
antenatal care (1)
Anti-epileptics (1)
Antibiotic allergy (1)
antibiotics (3)
anticoagulants (2)
antidepressants (4)
Antimicrobial resistance (2)
Antimicrobial Stewardship (1)
anxiety (1)
Aorta (1)
aortic stenosis (1)
Apoptosis (1)
Appendicitis (2)
arrhythmia (1)
arterioveneuze fistel, dialyse shunt (1)
Artificial Intelligence (3)
Aspergillus fumigatus (1)
Assessment (1)
asthma (7)
Asthma genes (1)
astma (1)
asylum seekers (1)
Ataxia (2)
atherosclerosis (3)
Atrial fibrillation (3)
Attitude medisch specialisten (1)
audiology (1)
autism (1)
autoantibodies (1)
autoantigen (1)
autoimmune blistering diseases (1)
autoimmune disease (6)
autologous stem cell transplantation (1)
Autophagy (2)
Axonal transport (1)
Balance (1)
bariatric surgery (1)
basic research (2)
Behandeling/follow-up (1)
Beslissingsondersteuning (1)
beta cell destruction (1)
Big Data (2)
Bijnier (1)
bile (3)
bile ducts (1)
biliary atresia (4)
bilirubin (1)
bio-informatics (1)
biochemie (2)
biofilm (1)
bioinformatics (1)
biomarker (2)
biomarkers (8)
biomaterials (1)
biomedical technology (3)
biorhythm (1)
bipolar disorder (3)
bleeding (2)
blood flow autoregulation (1)
blood loss (1)
Blood pressure (2)
Blood pressure variability (1)
blood-brain barrier (1)
bloodpressure (1)
borderline tumors of the ovary (1)
brain (3)
brain metastases (2)
Brain metastasis (1)
brain tumour (2)
BRCA1/2 (1)
BRCA1/2 mutation (1)
Breast (a)symmetry (1)
Breast augmentation mammoplasty (2)
breast cancer (5)
breast conserving surgery (1)
Breast implants (1)
Breast symmetry (1)
bronchial epithelium (1)
built environment (1)
Buruli Ulcer (3)
Calorie restriction (1)
Calprotectin (2)
cancer (32)
cancer cell apoptosis (1)
Cancer cell metabolism (1)
cancer cells (1)
cancer patients (2)
cannabis (1)
carcinogenesis (1)
Cardiac Amyloidosis (2)
cardiac differentiation (1)
Cardiac function (1)
cardiac output (1)
cardiac surgery (1)
cardio-pulmonary toxicity (1)
cardiogenetics (2)
cardiology (10)
cardiometabolic health (1)
cardiopulmonary bypass (1)
Cardiovasculaire effecten (1)
cardiovascular (4)
cardiovascular disease (6)
cardiovascular risk (1)
cardiovascular risk management (1)
cardiovascular surgery (1)
Cardiovascular toxicity (2)
care outside the guideliness (1)
caries (1)
carriers (1)
cartilage (2)
Catheterization lab (1)
celiac disease (4)
cell biology (1)
cell cycle (2)
cell death (3)
cell saver (1)
cellbiology (1)
cellular interactions (1)
cerebral palsy (1)
cervical radiculopathy (2)
Cervical spine (2)
cesarean delivery (1)
CHARGE syndrome (2)
chemotaxis (1)
chemotherapy (5)
chest CT (1)
child (2)
Child development (1)
child outcome (2)
childbirth (1)
children (7)
ChIP assay (1)
cholangiocyte (1)
cholestasis (1)
cholesterol fluxes (1)
chromosomal abnormalities (1)
chromosome (1)
chronic depression (2)
chronic disease (2)
Chronic Kidney Disease (5)
chronic lung allograft dysfunction (1)
chronic ventilatory support (1)
Chronische pijn (2)
Circadian rhythmicity (1)
cirrhosis (2)
Clinical decision making (1)
clinical decision-making (1)
clinical diagnostics (4)
clinical epidemiology (1)
clinical genetics (1)
Clinical retrospective patient outcome study (1)
Clinical Severity Score (1)
co-morbidity (1)
coagulation (1)
coating (1)
coccygodynie (1)
cochlear implant users (1)
cognition and outcome (2)
cognitive function (3)
cognitive impairment (1)
cognitive testing (1)
collect clinical information (1)
Colon carcinoma (1)
colonisation (1)
colorectal cancer (2)
colorectal cancer, CEA value, CT-scan, follow up (1)
colorectal surgery (3)
comorbidity: anxiety, aggression, emotion regulation problems, depression (1)
compensatory movements (1)
competency development (1)
complement (3)
complex congenital heart disease (1)
compliance (1)
complications (4)
Comprehensice geriatric assessment (1)
computed tomography (CT) (3)
Congenital anomalies (1)
congenital heart disease (3)
connective tissue disease (1)
Constipation (1)
continue glucose monitoring (1)
contraction (1)
contrastmiddel (1)
COPD (14)
Coronair angiografie (1)
coronary arteries (1)
coronary artery bypass grafting (1)
Coronary Artery Disease (3)
cosmetic outcome (1)
costs (3)
COVID-19 (6)
craniopharyngioma (2)
Craniotomy (1)
Critically ill children (1)
Crohn's disease (2)
Crohn's disease (3)
Crohn's disease (1)
CT (1)
CT imaging (2)
CT-scan (1)
cystic fibrosis (4)
cytokines (1)
Damage (1)
database (3)
database registry (1)
Deep brain stimulation (DBS) (6)
deletion (2)
delirium (1)
delivery agent (1)
dementia (3)
dental erosion (1)
dental hygiene (1)
dentist (1)
depression (4)
Depression, (2)
Depression, translational neuroscience (1)
dermatology (3)
development (3)
Developmental coordination disorder (1)
developmental disorder (1)
developmental disorders (1)
Developmental Dysplasia of the Hip (DDH) (1)
developmental psychopathology (1)
Dexamethasone (1)
diabetes (3)
Diabetes mellitus (4)
diabetis (1)
diagnostic importance (1)
diagnostic test (1)
diagnostics (3)
dialysis (3)
Diaphragm paralysis (1)
Diet (2)
dilated cardiomyopathy (1)
disease activity (1)
disease models (1)
Disease modifying therapy (1)
DNA (1)
DNA damage (1)
DNA damage response (1)
DNA methylation signatures (1)
donor (1)
Drosophila (2)
drug delivery (1)
Drug Interactions (1)
dry eye (2)
duplication (1)
Dupuytren's disease (1)
Dupuytren's disease (1)
Dystonia (6)
e-health (5)
early detection (1)
early life experiences (1)
Early Onset Ataxia (2)
echo duplex, diagnotische waarde (1)
echocardiography (2)
echogenic bowel (1)
eco-anxiety (1)
Education (2)
EEG-EMG (1)
effects (1)
Ehealth (10)
Elder (1)
elderly (6)
elderly cancer patients (1)
elderly patients (2)
electroconvulsive therapy (1)
Electronic Nose (1)
EMG (2)
EMG-analysis (1)
emphysema (1)
EMSA (1)
enamel (1)
end-expiratory lung volume (1)
endocrine disrupting chemicals (1)
endocrine therapy (1)
endocrinology (1)
endometriosis (2)
Endophenotypes (1)
Endothelial Cell (2)
endothelial cells (1)
endoveneuze laser behandeling (1)
energy metabolism (3)
engineering (1)
enkelletsel (1)
eNose (1)
epidemiology (9)
epidermolysis bullosa (1)
epigenetics (4)
epithelial cells (1)
epithelial disorders (1)
ercp (1)
errors (1)
erythropoietin (1)
Esophageal cancer (1)
esophageal carcinoma (2)
Esophageal pressure (1)
esophagus surgery (2)
Essential tremor (3)
ESWL (2)
ethics (1)
evidence-based medicine (1)
EVLT (1)
Ex vivo lung perfussion (1)
exercise testing (1)
exercise therapy (1)
Exercise training (1)
Exergames (1)
exome sequencing (3)
Extreme prematuur (1)
Faecalibacterium prausnitzii (1)
familial hypercholesterolemia (1)
Family history (2)
Farmacologie (1)
farmacology (1)
fatigue (2)
fatty acids (1)
fatty liver disease (1)
FDG PET/CT (2)
fecal incontinence (1)
fertility (1)
fetal gender (1)
fibrosis (3)
filling (2)
First Episode Psychosis (2)
first trimester anomaly scan (1)
first trimester ultrasound (1)
fitness (1)
fluid administration, hemodynamic monitoring (1)
fluid management (1)
Fluorescence imaging (1)
fMRI (1)
fNIRS-monitoring (1)
foot ulcers (1)
frailty (2)
Frailty screening (2)
functional genetics (2)
Functional stroke mimic (1)
Fungal Infections (1)
fysiotherapie (1)
gait (1)
galectin-3 (1)
Galgangatresie (1)
game (1)
gangliosides (1)
GBA1-gene (1)
GECKO (1)
Gender (1)
gene enrichment (1)
gene expression (1)
gene regulation (1)
general medicine (1)
general movements (1)
general practice (3)
general practitioner (1)
genetic diseases (1)
Genetic sequencing (1)
genetic testing (1)
genetics (5)
genome analysis (1)
genomic instability (1)
genotype-phenotype correlation (1)
geriatric oncology (1)
geriatrics (2)
glaucoma (2)
Glioblastoma (1)
Gliomas (1)
global child health (1)
global health (2)
Glomerular filtration rate (1)
Glucocorticoids (1)
glucose homeostasis (1)
growth hormone deficiency (1)
Guidelines (2)
Gunanine Nucleotide Exchange Factor (1)
Gut Microbiota Composition (2)
gut-liver acis (1)
gyneacological oncology (1)
gynecological oncology surgery (1)
haemophilia (2)
hand (1)
Head and neck cancer (5)
Health care professionals (1)
Health care utilization (1)
health economics (3)
Health indicators (1)
Health literacy (1)
health-related quality of life (4)
healthcare education (1)
hearing impairment (1)
hearing rehabilitation (1)
heart (14)
heart failure (7)
Heart rate variability (1)
heart transplantation (1)
heart valve replacement (1)
heat shock proteins (1)
Heel prick Screening (1)
hematology, cancer, critical care, outcome (3)
hematopoiesis (5)
hemodynamic monitoring (2)
hemodynamics (1)
hemostasis (2)
heparin induced thrombocytopenia (1)
hepatitis (2)
hepatocellular carcinoma (1)
hereditary cancer (1)
hereditary kidney disease (1)
hereditary tumours (1)
HFOV (2)
Hibernation (4)
Hidradenitis suppurativa (1)
hip (1)
hip and knee prothesis (2)
Hip artroplasty (1)
Historical controls (1)
HIV (3)
Hodgkin lymphoma (2)
Home mechanical ventilation (3)
Honours education (1)
hormone receptors (1)
HPB surgery (1)
huisarts (1)
Huisartsgeneeskunde (1)
human genetics (1)
human hematopoietic stem cells (3)
Humeral Fractures (1)
hydrochlorothiazide (1)
hydrogen sulfide (1)
hymenoptera venom allergy (1)
hyperglycaemia (1)
Hyperkinetic movement disorders (2)
Hypertensie (1)
hypoglycemia (1)
hypophospatemic rickets (1)
hypoplastic left heart syndrome (1)
hypotension (1)
IBD (4)
IGF-1 (1)
image biomarker (2)
imaging (10)
imaging, biomarkers (1)
Immune checkpoint inhibitors (3)
immune response (1)
immune suppression (1)
Immune-related adverse events (1)
immunity (1)
immunology (11)
immunosuppression (1)
immunotherapy (4)
implant infection (2)
in vitro (1)
in vitro fertilization (1)
Inborn Error of Metabolism (1)
incidence (1)
incontinence (2)
individualised treatment (1)
infant (2)
infant assessment (2)
infant development (3)
Infant Stool Colour Card (1)
infection (3)
Infection and inflammation (1)
Infectious diseases (1)
Infective Endocarditis (1)
inflammation (5)
Inflammatory bowel disease (3)
Inflammatory rheumatic disease (3)
Informatie-uitwisseling (1)
Information technology (1)
Inguinal Hernia Surgery (1)
innovatie van zorg (2)
insulin (1)
insuline-glucose metabolism (1)
insulitis (1)
Integrative care (1)
intellectual disability (1)
Intensive care (1)
interactie (1)
interprofessional education (2)
interventions in obstetrics (1)
Interviews (1)
Interviewstudie (1)
intestinal disease (2)
intestinal disorder (1)
intestinal integrity (1)
intestinal transplantation (2)
Intestinal wall permeability (1)
intestine (1)
Intracraniele druk (1)
Intraoperative neurophysiology (1)
IONM (1)
iPSC (1)
iron deficiency (2)
ischemia (3)
ischemia-reperfusion injury (1)
ischemia/reperfusion injury (2)
ischemic stroke (2)
Isolation (1)
isotopes (1)
IVF (3)
jaundice (2)
joint (2)
Ki67 proliferation index (1)
kidney (6)
kidney disease (5)
Kidney Donation (3)
kidney transplantation (13)
kidneydonor (1)
kinetic modeling (1)
Klinische onderzoeksstage (1)
knockout mouse (1)
kwaliteit van leven (2)
kwaliteit van zorg (1)
laboratory animals (10)
language development (1)
language screening (1)
laparoscopy (1)
laryngectomy (3)
late effects of treatment (1)
Leadership (2)
learning curve sonologist (1)
learning organization (1)
leefstijl (1)
leukemia (3)
leukemic stem cells (2)
LifeLines (2)
lifestyle (3)
liposomes (1)
lipotoxicity (1)
liver (3)
liver cancer (1)
liver disease (5)
liver diseases (1)
liver failure (1)
liver fibrosis (1)
liver metastases (1)
liver resection (1)
liver transplantation (10)
livercirrhosis (1)
locally advanced rectal caner (1)
locomotion (1)
long-term survival (1)
lumg transplantation (1)
lung (4)
lung cancer (5)
Lung function (1)
lung mechanics (2)
lung nodules (2)
lung recruitment (1)
lung transplantation (5)
lymphoma (2)
lynch syndrome (1)
machine learning (Matlab/Rstudio) (1)
machine perfusion (2)
major depressive disorder (1)
mass spectrometry (2)
mast cells (1)
mastocytosis (3)
measurement tool (1)
mechanical ventilation (9)
medical comorbidity (1)
medical device (4)
medical education (3)
medical imaging (8)
medically unexplained symptoms (2)
medication (3)
Medication reviews (1)
medication safety (1)
medication treatment (1)
medicine (1)
melanoma (5)
Meningioma (2)
meno-pauze (1)
mental retardation (1)
metabolic diseases (5)
Metabolic signaling (1)
metabolic syndrome (3)
metabolism (3)
metabool syndroom (3)
metformin (1)
method development (2)
microbiome (1)
microbiota (3)
microcephaly (1)
Microglia (1)
microRNA (2)
Minimally invasive parathyroidectomy (1)
mitochondria (1)
MitraClip (1)
Mobile electrocardiogram devices (1)
Mobility (1)
Modus partus (1)
molecular biology (2)
molecular chaperones (1)
Molecular Fluorescence Guided Surgery (1)
molecular mechanisms (1)
molecular microbiology (1)
Molecular tumour board (1)
molecular typing (1)
Monoclonal antibodies (1)
monocytes (1)
mood disorders (1)
Motor development (2)
Mouse models (1)
movement disorders (3)
MRI (7)
MRI / CT (1)
MRI / magnetic resonance imaging (3)
MRI brain (1)
MRS (1)
mucus clearance (1)
multi-morbidity (1)
Multi-organ failure (1)
Multi-phase CT (1)
multidrug resistance (1)
Multimorbidity (3)
multiple myeloma (2)
multiple sclerosis (3)
Musculoskeletal pain (1)
Music (1)
music intervention (1)
music therapy (1)
mutations (2)
myelin (1)
myocardial infarction (2)
myoclonus (1)
myoclonus dystonia (1)
NASH (1)
nasopharyngeal carcinoma (1)
Necrotische Enterocolitis (1)
necrotising enterocolitis (1)
nefropathie (1)
neglected diseases (1)
Neglected Tropical Diseases (1)
neoadjuvant chemoradiotherapy (1)
Neonatal growth (1)
neonatal hypoglycemia (1)
Neonatal hypoxic-ischaemic encephalopathy (1)
Neonatal outcome (1)
neonates (2)
neonatology (1)
nephrology (2)
neuro-endocrine tumors (1)
neurobiology (1)
neurocognition (1)
neurodegeneration (4)
neurodegenerative diseases (3)
neurodevelopmental impairment (1)
neurodevelopmental outcome (1)
neuroendocrine tumor (1)
Neuroimaging (5)
neuroinflammation (1)
neurological development (1)
neurology (1)
neuromuscular blockade (1)
neuropathic pain (1)
neuropathy (1)
neuropsychiatric symptoms (1)
Neurosurgery (4)
neurotransmitters (1)
neutropenia (1)
new genes (1)
nier (1)
non-Hodgkin's disease (1)
Non-invasive ventilation (2)
Non-motor symptoms (2)
Noordzeeziekte (1)
Nuclear Medicine (1)
nuclear receptors (1)
nursing home (1)
Nursing home residentss (1)
nutrient addiction (1)
nutrition (8)
obesity (6)
Occupational exposures (1)
Occupational health (1)
Older adults (1)
oligodendrocytes (1)
oncological epidemiology (2)
oncology (5)
oncoplastic surgery (1)
ongeplande heropname (1)
online wearables (1)
operative surgical procedure (1)
opthalmologic problems (1)
organ preservation (3)
organ transplant (1)
organ transplantation (2)
orthopedics (3)
osteomyelitis (1)
otolaryngology (1)
Ouderen (1)
outcome (1)
outcome and cognition (1)
Outcome Assessment (1)
Outcome measurement (4)
Outcomes (2)
ovarian cancer (3)
Overactieve blaas (2)
overweight (2)
Overweight/obesity (1)
oxidative stress (2)
oxygenation (1)
pain (2)
PALB2 mutation (1)
palliatief (1)
Palliatieve zorg (3)
palliative care (1)
pancreatic resection (1)
pancreatoduodenectomie (1)
paralysis (1)
parental support (1)
Parkinson disease (4)
Parkinson's disease (4)
Parkinson's disease (2)
Parkinson’s disease (1)
Parkinson's disease (4)
Participation restriction (1)
pathological complete response (1)
pathology (1)
pathway analysis (1)
Patiënt-gerichtheid (1)
patient centered care (1)
patient experiences (2)
Patient perspective (1)
patient related research (1)
patient satisfaction (1)
Patient-Reported-Outcomes (1)
PD-L1 immunohistochemistry (1)
pediatric cardiology (2)
Pediatric gastroenterology (1)
Pediatric rehabilitation (1)
pediatrics (6)
Percutane Nefro-Litholapaxy (2)
Percutaneous coronary intervention (PCI) (1)
Percutaneous intervention (2)
Peri-Acetabular Osteotomy (PAO) or Bernese/Ganz osteotomy (1)
perinatal care and psychiatry (1)
perineal wound healing (1)
periodontitis (1)
perioperative care (1)
Periprosthetic joint infection (1)
peritonitis (1)
Persistent somatic symptoms (1)
personal medicine (1)
personalized (1)
Personalized medicine (3)
PET (5)
pet scintigraphy (1)
PET-tracer (1)
Peyronie disease (1)
pharmacodynamics (1)
pharmacokinetics (1)
pharmacology (4)
Phelan-McDermid syndrome (1)
phenomenology (1)
phenotype-genotype study (1)
phenylketonuria (1)
photometry (1)
physical activity (3)
physical and mental functioning (1)
physical therapy (1)
physiology (2)
placenta (1)
plasmacytoma (1)
plastic surgery (1)
platelet (1)
polisomnography (1)
Polycomb (1)
polypharmacy (6)
population cohort study (1)
population screening (2)
portal hypertension (1)
Positron Emission Tomography (1)
Postgraduate Medical Education (2)
postoperative complications (2)
postoperative outcome (1)
postoperative pain (1)
posttraumatic (1)
postural control (1)
potassium (1)
pre-clinical imaging (1)
pre-peritoneal wound catheters (1)
Precision medicine (1)
predictiemodel (1)
Predictiemodellen (1)
prediction (1)
prediction modeling (2)
preeclampsia (1)
pregnancy (10)
Prehabilitation (1)
Prematuren (1)
prenatal diagnosis (2)
prenatal diagnostics (2)
prenatal programming (1)
preservation fluids (1)
preterm (1)
preterm birth (1)
Prevalence of cancer (1)
prevention (4)
preventive cardiovascular medication (1)
primairy health care (1)
primary care (7)
primary care, gastro-enteritis, children, out-of-hours service, pediatrics. (2)
Primary Hyperparathyroidism (1)
probiotics (1)
Proefschrift (1)
prognosis (2)
Prolapse surgery (1)
proliferation (1)
Promoveren (1)
prospective cohort study (1)
prostate cancer (1)
Prosthetic Valve (1)
protein aggregation (1)
protein kinase inhibitors (1)
protein restoration therapy (1)
proteomics (3)
prothrombin complex concentrate (1)
PSMA PET/CT (1)
Psychiatric symptoms (1)
psychiatry (1)
psychiatry, high-field MRI (1)
psychological stress (1)
Psychology (1)
psychosis (1)
psychosocial (2)
psychosocial and lifestyle determinants (1)
psychotherapy (1)
Publiceren (1)
pulmonary embolism (1)
pulmonary hypertension (1)
pulmonary rehabilitaion (1)
Pulmonary rehabilitation (1)
QST (1)
qualitative research (4)
quality improvement (1)
quality of life (7)
quality of reduction (1)
Quantification (1)
quantitative sensory testing (1)
questionnaire (3)
questionnaire research (1)
Radiology (11)
radiotherapy (32)
Randomized comparative trial (1)
randomized controlled trial (1)
raynaud (1)
RCT (1)
real world dosing (1)
Recommendation (1)
recovery (1)
rectal cancer (2)
rectum carcinoma (1)
Recurrence (1)
referral (1)
refugees (1)
regeneration (3)
rehabilitation (5)
Relatives (1)
Renal cell carcinoma (1)
renal disease (2)
renal transplantation (1)
renal tubular epithelium (1)
reperfusion (2)
Reproducibility of Results (1)
Reproduction (1)
reproductive health (1)
reproductive immunology (2)
respiratory failure (1)
respiratory viruses (2)
restoration (1)
retina (2)
retinal physiology (1)
retrospective (1)
revision surgery (1)
rheologic and oxygen transport capacity (1)
risk factors (2)
RNA (1)
Robot-assisted surgery (1)
ROC curve (1)
running (1)
saliva (1)
SARS-CoV-2 vaccination (1)
Schildklierkanker (1)
schizophrenia (2)
screening (1)
Screening tools (3)
Seating devices (1)
Second opinion (1)
Selective Internal Radiotherapy (1)
Self - Determination Theory (1)
self-management (1)
self-renewal (2)
sensitisatie van het centraal zenuwstelsel (1)
Sentinel lymph node (1)
Sepsis (2)
Sequencing (1)
serious gaming (1)
severe mental disorders (1)
sex-specific (1)
shared decision making (1)
shear wave ultrasound (1)
signal transduction (1)
Single Nucleotide Polymorphisms (SNP) (1)
siRNA (1)
Sjogren's syndrome (1)
Sjögren's syndrome (1)
skeletal muscle mass (1)
Skin cancer (3)
Sleep (1)
small for gestational age (1)
small molecular drugs (1)
Social media (1)
soft tissue sarcoma (2)
spataderen (1)
spectroscopy (1)
Spine surgery (1)
sport (1)
sport medicine (1)
sports injury (1)
Stage wetenschap / research project (1)
statistics (1)
steatosis hepatis (1)
Stem cell division (2)
stem cells (4)
stenose (1)
stoma (1)
Streptococcus pneumoniae (2)
stress (4)
stroke (2)
Stuitbevalling (1)
stuitpijn (1)
subarachnoid hemorrhage (1)
surgery (7)
surgery induced muscle loss (1)
surgical oncology (2)
surgical resection (1)
surgical treatment (1)
survey (2)
survival (2)
survival, Epstein-Barr virus (1)
Survivor care (3)
symptom perception (1)
synaptic density (1)
syndrome (1)
Systematic Review (3)
systemische sclerose (1)
systems biology (1)
T cell genes (1)
TARC (1)
target organ injury (1)
teeth restoration (1)
teleconsultatie (1)
telemonitoring (1)
tendinopathy (1)
therapy compliance (1)
therapy resistance (1)
Thiosulphate sulfurtransferase activation (1)
thoracic endovascular aortic repair (1)
thoracic irradiation (1)
thrombolysis (1)
thrombosis (5)
Thyroid cancer (1)
thyroid gland (1)
time alignment (1)
TIPS (1)
TNF (1)
tolerance induction (1)
tolvaptan (1)
total hip arthroplasty (2)
total knee arthroplasty (1)
Toxicities (1)
Transanal TME (1)
transcatheter aortic valve implantation (1)
transcraniëel Doppler onderzoek (TCD) (1)
Transcranial Magnetic Stimulation (2)
transcription factor (1)
transcriptional regulation (2)
translation validation (1)
translational (4)
transplant rejection (1)
transplantatation (1)
Transplantatie (1)
transplantation (34)
transplantation medicine (1)
Transplantation surgery (1)
TransplantLines (2)
transport proteins (1)
Transpulmonary pressure (1)
traumachirurgie (1)
traumatic brain injury (2)
traumatisch hersenletsel (1)
Treatment (3)
Treatment goals (1)
Treatment response (1)
tremor (1)
tricyclic antidepressants (1)
triglyceride (1)
trombose (1)
tropical medicine (1)
TSST (1)
Tuberculosis (1)
type 2 diabetes (2)
tyrosinemia (1)
uitdroging (1)
uitkomst (1)
ulcerative colitis (5)
ultrasound (4)
underrepresentation women (1)
upper extremity (2)
urinary tract infection (2)
Urolithiasis (3)
vaatmetingen (1)
vaccine (2)
Validation study (2)
vascular graft infection (1)
vascular medicine (4)
vascular surgery (3)
vasculitis (1)
Venous thromboembolisms (1)
venous thrombosis (4)
Ventilator induced lung injury (2)
Verteporfin (1)
vesicular trafficking (1)
vestibular dysfunction (1)
Virtual Reality (4)
virus (2)
visual field testing (1)
visual neuroscience (1)
vitamin D (1)
vitamin D deficiency (1)
vitamin K antagonists (1)
voetletsel (1)
volumetry (1)
Von Hippel-Lindau (1)
VTE (1)
waiting list (1)
Weaning (1)
Wegener's granulomatosis (1)
West Africa (1)
whole exome sequencing (1)
Wnt signaling (1)
Work capacity evaluation (1)
Work of breathing (1)
X-rays (1)
young patients (1)
zebrafish (2)
Zelfbeoordelingslijst (1)
zuurstofsaturatie (1)
Novel gene mutation imaging with 2-HG MR spectroscopy in low grade gliomas; a validation study.
Keywords: imaging
oncology
Radiology
Researchers:
prof. dr. R.A. Dierckx
dr. A van der Hoorn
dr. P.J. van Laar
Nature of the research:
This research is conducted at the department of radiology in the UMCG in close collaboration with tin department of neurology, neurosurgery, laboratory medicine and pathology. The current project will be embedded in the research line: Diagnosis, treatment-planning and -evaluation in brain and head/neck tumours. This research line is a main research focus of the department of radiology as part of the Medical Imaging Center (MIC) in the UMCG. For MPDI students it fits to both the ‘oncology’ and ‘medical neurosciences and neurological diseases’ track. The current project will consist of a prospective patient study.
Fields of study:
neurology
oncology
radiology
Background / introduction
Gliomas are the most common primary brain tumour. The incidence is relatively low with 7 per 100.000 (1), however they account for a large number of lost of healthy life years (2). Gliomas are divided in low and high grade gliomas. Low grade gliomas occur in a relatively young population of 30-50 years (3). Surgery in not always possible as tumours might be located next to an eloquent brain area. Treatment with only chemo- and radiotherapy is preferred in these cases. However, the diagnosis should be firmly established beforehand. A biopsy is currently the only option to establish the diagnosis. However a biopsy is invasive and has associated complications and mortality. The complication rate of a biopsy of a primary brain tumour is 4,5% (4). This is most commonly a haemorrhage which is also responsible for most of the mortality of about 2%. A non-invasive method to assess the diagnosis is clearly wanted.
A novel MR spectroscopy method might help. MR spectroscopy is able to differentiate different metabolites based upon the resonance frequency of these metabolites. The majority (80-90%) of the low grade gliomas have a isocitrate dehydrogenases-1 (IDH-1) or ID-2 gene mutation (5,6). An IDH mutation always result in the production of the onometabolite 2-hydrocyglutarate (2-HG). 2-HG can be measured with MR spectroscopy (7). 2-HG is characteristic for low grade gliomas only and might provide a non-invasive alterative to establish the diagnosis.
2-HG is limited investigates thus far, but provide the unique opportunities to visualise a gene mutation with MR and establish the diagnosis of low grade gliomas non-invasively. However, further validation of 2-HG MR spectroscopy is needed. The correlation between in vivo 2-HG MR spectroscopy and ex vivo 2-HG concentration should be validated and is the subject of the current project.
Research question / problem definition
What is the correlation between 2-HG MR spectroscopy and IDH mutation status in low grade gliomas? What is the correlation between the concentration of 2-HG on MR spectroscopy and the 2-HG concentration of ex vivo tissue?
Workplan
research project. 2-HG MR spectroscopy already has been tested on our MR scanners and is feasible (see figure 1). Slight optimisation of the post processing might be needed. The student will be supervised by MR spectroscopy expert for this part. Supervisions will be also provided by clinical experts and the student will work in close collaboration with the department of laboratory medicine. A pro-active work attitude is expected from the student.
To acquire a clinical view on the patients involved in this research, it will be possible for the student to visit the neurology department and see the out patients visits. Joining the neuro-radiologist during reporting is also possible. Joining the multidisciplinary team discussions on Wednesdays furthers adds to the clinical knowledge within this research subject.
References
1. Ostrom QT, Gittleman H, Xu J et al. CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2009–2013. Neuro Oncol 2016; 18: v1-v75.
2. Burnet NG, Jefferies SJ, Benson RJ, Hunt DP, Treasure FP. Years of life lost (YLL) from cancer is an important measure of population burden – and should be considered when allocating research funds. Br J Cancer 2005; 31: 241-245.
3. Van den Bent MJ, Wefel JS, Schiff D, et al. Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas. Lancet Oncol. 2011;12(6):583-593.
4. Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI. Complications following stereotactic biopsy needle biopsy of intracranial tumors. World Neurosurg 2015; 84: 1084-1089.
5. Sanson M, Marie Y, Paris S, et al. Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol 2009; 27: 4150-4154.
6. Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009; 360: 765-773.
7. Leather T, Jenkinson MD, Das K, Poptani H. Magnetic resonance spectroscopy for detection of 2-hydroxyglutarate as a biomarker for IDH mutation in gliomas. Metabolites 2017; 7: 1-16.