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Make a choice Prof. dr. R.T. Gansevoort E. Meijer M. van Gastel

Project properties

Title	Quality of Life and life style in ADPKD
Keywords	health-related quality of life adpkd
Researchers	Prof. dr. R.T. Gansevoort E. Meijer M. van Gastel
Nature of the research	Observational study
Fields of study	Sociale Geneeskunde internal medicine nephrology

Background / introduction

ADPKD is the most frequent hereditary kidney disease. Patients develop cysts in their kidney and ultimately develop kidney failure. Although increasing knowledge of the underlying pathophysiology had led to identification of potential targets for pharmacologic therapy, not much is known about life style factors influencing the disease course. Another subject that deserves attention in this population is their quality of life

Research question / problem definition
to investigate influence of life style factore (smoking, alcohol, BMI) on kidney growth and change in eGFR and to investigate quality of life by questionnaires

Workplan
measurement of total kidney volume on MRI processing of questionnaires statistical analyses. Of note: we have a well phenotyped, national cohort of ADPKD patients, consisting of 10% of the total ADPKD population in the Netherlands. If the student is interested, there are numerous possibilities for further research in our research group

References

1. Bart J Kramers , Iris W Koorevaar , Joost P H Drenth , Johan W de Fijter , Antonio Gomes Neto , Dorien J M Peters , Priya Vart , Jack F Wetzels , Robert Zietse , Ron T Gansevoort , Esther Meijer Salt, but not protein intake, is associated with accelerated disease progression in autosomal dominant polycystic kidney disease. Kidney Int 2020 2. Meijer E, Visser FW, van Aerts RMM, Blijdorp CJ, Casteleijn NF, D'Agnolo HMA, Dekker SEI, Drenth JPH, de Fijter JW, van Gastel MDA, Gevers TJ, Lantinga MA, Losekoot M, Messchendorp AL, Neijenhuis MK, Pena MJ, Peters DJM, Salih M, Soonawala D, Spithoven EM, Wetzels JF, Zietse R, Gansevoort RT. Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial. ; JAMA. 2018 Nov 20;320(19):2010-2019.