Onderzoeksproject aanpassen

Projecten zijn uitsluitend aan te passen door bij het project behorende onderzoekers.

Geef via het uitrolmenu aan welke onderzoeker u bent. Nadat op u de button 'Edit project' heeft geklikt, wordt automatisch een e-mail verstuurd naar het e-mailadres van de onderzoeker die u heeft gespecificeerd.

In deze e-mail staat een link waarmee u het project kunt wijzigen.

Your name

Make a choice Dr. P. van Duijvendijk mw T (Tanja) Argillander B.C. van Munster

Project properties

Title	Frailty as a predictor of postoperative outcomes and survival after colorectal cancer surgery
Keywords	colorectal cancer Frailty screening
Researchers	Dr. P. van Duijvendijk mw T (Tanja) Argillander B.C. van Munster
Nature of the research	Retrospective cohort study
Fields of study	surgery geriatrics

Background / introduction

Surgical resection is the only curative treatment option for colorectal cancer. Frail older patients are at risk for adverse outcomes which may outweigh the benefits of surgery. The first step in preventing adverse outcomes is to identify the patients at risk. The Groningen Frailty Indicator (GFI) is a 15-item frailty screening instrument that has been shown to predict adverse outcomes after hip fracture surgery1 and in patients with end-stage renal disease2. Its utility in the outcome prediction for older patients with colorectal cancer has not been studied previously.

Research question / problem definition
Can the GFI be used to predict postoperative outcomes and survival after colorectal cancer surgery?

Workplan
The student will complete a database with relevant patient information, perform statistical analysis, and write a report on the findings. Data collection will be performed at Isala Hospital in Zwolle. There will be a possibility to contribute to a publication of the findings in a peer-reviewed journal. The student will work under direct supervision of a PhD student.

References
References: 1. Winters AM, Hartog LC, Roijen H, et al. Relationship between clinical outcomes and Dutch frailty score among elderly patients who underwent surgery for hip fracture. Clin Interv Aging. 2018;13:2481–2486. 2. Meulendijks FG, Hamaker ME, Boereboom FT, et al. Groningen frailty indicator in older patients with end-stage renal disease. Ren Fail. 2015;37(9):1419-1424.