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Project properties

Title Prediction model for identifying ISM patients within the HVA population
Keywords mastocytosis hymenoptera venom allergy
Researchers J.N.G. Oude Elberink
M.C. Onnes
Nature of the research Database research
Fields of study allergology
Background / introduction
Wasp venom allergy (WVA) is a potentially life threatening condition. A group of patients with WVA suffer from an underlying condition called mastocytosis. In these patients reactions are generally more severe, and unfortunately their response to treatment is lower and non-durable, meaning treatment should be continued lifelong. Therefore, identification of these patients within the WVA population is essential. Hence, we perform bone marrow biopsies to confirm or exclude mastocytosis.
Research question / problem definition
As bone marrow biopsies are painful procedures for patients, we aim to reduce the number of biopsies by developing a prediction model for mastocytosis in the WVA population based on clinical and biochemical characteristics.
Workplan
To develop this model, characteristics of mastocytosis and non-mastocytosis patients should be inventoried and assessed. We are looking for a medical bachelor student who wants to do a TTT-project or Pilot Project. You will assist in data extraction from patient files and databases. After extraction you will perform statistical analyses under the supervision of a PhD candidate and write your own report.
If you are interested participation in other research projects is also possible, as is extension of the project into a scientific clerkship or MD/PhD programme.
References
Golden DBK. Insect Sting Anaphylaxis. Immunol Allergy Clin N Am 2007:27;261-272.
Zanotti R, Lombardo C, Passalacqua G et al. Clonal mast cell disorders in patients with severe Hymenoptera venom allergy and normal serum tryptase levels. J Allergy Clin Immunol 2015:136(1);135-9.
Vos BJPR, Van Anrooij B, van Doormaal JJ et al. Fatal Anaphylaxis to Yellow Jacket Stings in Mastocytosis: Options for Identification and Treatment of At-Risk Patients, JACI Pract 2017:5(5);1264-1271.
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