Molecular Fluorescence Guided Surgery in intracranial meningiomas

Neurosurgery Meningioma Molecular Fluorescence Guided Surgery

prof.dr. F.A.E. Kruyt
Prof. dr. R.J.M. Groen
mw. B.M Dijkstra

Nature of the research:
This project is part of an ongoing clinical trial. The student can gain experience with intra- and post-operative study procedures, labwork and reviewing literature.

Fields of study:

Background / introduction
Meningiomas are the most frequently occurring intracranial brain tumors in adults. Treatment can be curative with complete surgical resection. To safely increase the extent of resection, improving the intra-operative identification of meningioma tissue is necessary. The approach studied in this project is Molecular Fluorescence Guided Surgery (MFGS). This technique is based on a “red flag” mechanism by fluorescently labelling tumor cells with a tracer. We previously identified Somatostatin Receptor Type 2 (SSTR2) and Vascular Endothelial Growth Factor (VEGF) as candidate biomarkers for MFGS in meningiomas. SSTR2 can be targeted with the novel preclinically evaluated tracer 800CW-TATE, and targeting of VEGF is being done with the already clinically applicable Bevacizumab-IRDye800CW.
Research question / problem definition
Currently, we are investigating the feasibility of using Bevacizumab-IRDye800CW in meningioma patients in a clinical study called the LUMINA trial.
The LUMINA trial is open for patient inclusion. The student will help with conducting the clinical trial under supervision of the PI and an MD/PhD student. Depending on the interests of the student, this could mean involvement in the intra-operative study procedures, postoperative tumor analysis at the department of Pathology or reviewing literature. These contributions may lead to co-authorship and potentially to a MD/PhD project.

This current project is a collaboration between the departments of Neurosurgery, Medical Oncology, and Pathology & Medical Biology, and the Optical Molecular Imaging Groningen (OMIG) in the UMCG, and the department of Radiology & Nuclear Medicine and Molecular Genetics in the ErasmusMC.
Dijkstra, B. M., Jeltema, J. R., Kruijff, S. & Groen, R. J. M. The application of fluorescence techniques in meningioma surgery—a review. Neurosurgical Review 42, 799–809 (2019).

Dijkstra, B. M. et al. SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery. Acta Neurochirurgica 160, 1539–1546 (2018).

Dijkstra, B. M. et al. Evaluation of Ac-Lys(0)(IRDye800CW)Tyr(3)-octreotate as a novel tracer for SSTR(2)-targeted molecular fluorescence guided surgery in meningioma. Journal of neuro-oncology (2021) doi:10.1007/s11060-021-03739-1.

Koller, M. et al. Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers. Nature communications 9, 3739 (2018).
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