Projectdetails

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Prevalence, predictors and clinical outcome of new-onset heart failure with preserved ejection fraction after an acute myocardial infarction

Keywords:
acute myocardial infarction heart failure

Researchers:
Prof. dr. A.A. Voors

Nature of the research:
clinical, epidemiology

Fields of study:
epidemiology cardiology

Background / introduction
Much is known about the prevalence, predictors and treatment of heart fialure with reduced ejection fraction after an acute myocardial infarction. However, due to early reperfusion using primary PCI, the gerat mjority of patients have a normal left ventricular ejection fraction after an acute myocardial infarction and these patients can still develop heart failure. However, data on the prevalence, predictors and clinical outcome of new-onset heart failure with preserved ejection fraction after an acute myocardial infarction is very limited.
Research question / problem definition
What is the prevalence, predictors and clinical outcome of new-onset heart failure with preserved ejection fraction after an acute myocardial infarction
Workplan
The department of cardiology of the UMCG has collected blood smples and information from approximately 2000 patients with a myocardial infarction who already signed informed consent. The student will collect information abou the follow-up of these patients, to capture which patients died, had another myocardial infarction or had to be admitted to the hopsital for heart failure. The student will analyse the information and will build risk prediction models for these clinical outcomes after an acute myocardial infarction.
References
1. ST-segment elevation myocardial infarction. Vogel B, Claessen BE, Arnold SV, Chan D, Cohen DJ, Giannitsis E, Gibson CM, Goto S, Katus HA, Kerneis M, Kimura T, Kunadian V, Pinto DS, Shiomi H, Spertus JA, Steg PG, Mehran R. Nat Rev Dis Primers. 2019 Jun 6;5(1):39.
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