Potassium supplementation in chronic kidney disease patients - a randomized double blind placebo control study [copy]

nutrition Chronic Kidney Disease potassium

Dr. M.H. de Borst
SMH Yeung

Nature of the research:
Clinical trial

Fields of study:

Background / introduction
Fruits and vegetables are part of a healthy diet which is known to be beneficial for our health (1,2). Potassium is enriched in fruits and vegetables. Large observational studies accross different patient cohorts have shown that higher urinary potassium excretion, a surrogate marker for potassium intake, is inversely associated with cardiovascular events, hypertension, chronic kidney disease (CKD), and mortality (3-10). Here, we want to study the beneficial effect of potassium supplementation on blood pressure and kidney function in CKD patients. This clinical trial is part of a consortium, thus we cooperate with Erasmus MC, LUMC, and Amsterdam UMC in order to complete the clinical trial.
Research question / problem definition
Does potassium supplementation improve kidney function and/or blood pressure in chronic kidney disease patients?
We ask the student to support our clinical trial. The student will learn about the design, execution, and interpretation of a clinical trial performed in an academic medical centre.

Epidemiological data is readily available to analyze associations of potassium excretion with other variables or adverse outcomes.

What we can offer:
- Data collection, data entry and analyses of follow-up data of trial patients
- Possibility for investigating related research questions in your own field of interest
- Development of your writing and statistical skills
- Development of your presentation skills by presenting data on international meetings
- Possibility to publish in international peer-reviewed scientific journals

We are looking for an independent student with:
- Coordination and cooperation skills
- Clear in communication
- Writing skills are a pre
- Mastering the Dutch and English language
1) Sacks FM, Svetkey LP, Vollmer WM, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med. 2001;344(1):3-10.
2) Appel LJ, Moore TJ, Obarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997;336(16):1117-1124.
3) Mente A, O'Donnell MJ, Rangarajan S, et al. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014;371(7):601-611.
4) Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ. 2013;346:f1378.
5) O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-623.
6) Chang HY, Hu YW, Yue CS, et al. Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men. Am J Clin Nutr. 2006;83(6):1289-1296.
7) He J, Mills KT, Appel LJ, et al. Urinary Sodium and Potassium Excretion and CKD Progression. J Am Soc Nephrol. 2016;27(4):1202-1212.
8) Smyth A, Dunkler D, Gao P, et al. The relationship between estimated sodium and potassium excretion and subsequent renal outcomes. Kidney Int. 2014;86(6):1205-1212.
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