Frailty as a predictor of postoperative outcomes and survival after colorectal cancer surgery

colorectal cancer Frailty screening

Dr. P. van Duijvendijk
mw T (Tanja) Argillander
B.C. van Munster

Nature of the research:
Retrospective cohort study

Fields of study:
surgery geriatrics

Background / introduction
Surgical resection is the only curative treatment option for colorectal cancer. Frail older patients are at risk for adverse outcomes which may outweigh the benefits of surgery. The first step in preventing adverse outcomes is to identify the patients at risk. The Groningen Frailty Indicator (GFI) is a 15-item frailty screening instrument that has been shown to predict adverse outcomes after hip fracture surgery1 and in patients with end-stage renal disease2. Its utility in the outcome prediction for older patients with colorectal cancer has not been studied previously.
Research question / problem definition
Can the GFI be used to predict postoperative outcomes and survival after colorectal cancer surgery?
The student will complete a database with relevant patient information, perform statistical analysis, and write a report on the findings. Data collection will be performed at Isala Hospital in Zwolle. There will be a possibility to contribute to a publication of the findings in a peer-reviewed journal. The student will work under direct supervision of a PhD student.
1. Winters AM, Hartog LC, Roijen H, et al. Relationship between clinical outcomes and Dutch frailty score among elderly patients who underwent surgery for hip fracture. Clin Interv Aging. 2018;13:2481–2486.

2. Meulendijks FG, Hamaker ME, Boereboom FT, et al. Groningen frailty indicator in older patients with end-stage renal disease. Ren Fail. 2015;37(9):1419-1424.
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