Projectdetails

of


Risk factors for skin cancer after solid organ transplantation

Keywords:
Skin cancer organ transplantation immunosuppression

Researchers:
prof. dr. S.J.L. Bakker
dr. E. Racz

Nature of the research:
Prospective cohort study

Fields of study:
dermatology pathology internal medicine

Background / introduction
This research is embedded in the longitudinal cohort TransplantLines. The UMCG is the only center in the Netherlands which has the license to perform all kind of organ transplantations. Chronic immunosuppression after solid organ transplantation is a risk factor for cutaneous squamous cell carcinoma (cSCC) development, and organ transplant recipients have a >50-times higher risk of developing squamous cell carcinoma than the general population.
Although factors including immunosuppression, age, sex, pigment, and UV exposure play
critical roles in the risk of developing KC, these risk factors do not explain well enough why some patients develop high risk skin cancer after transplantation and others do not. In a recent large cohort study HLA antigen mismatch between a donor and a recipient was associated with a protective effect against posttransplant skin cancer. We would like to explore this in the Transplantlines cohort and look for further novel factors that contribute to post-transplant skin cancer development.
Research question / problem definition
Can we find factors that even better predict the development of skin cancer after organ transplantation than currently possible?
Workplan
All histology reports of patients in the Transplantlines cohort are currently being retrieved from PALGA, a nationwide network for registry of histo- and cytopathology in the Netherlands. You will enter skin cancer data in the Transplantlines database, and after this characterize the subset of patients who developed skin cancer after organ transplantation and compare to those who have not.

During this research clerkship you will learn how to perform statistical analysis in a large dataset and how to write an article.
References
Vos M, Plasmeijer EI, van Bemmel BC, van der Bij W, Klaver NS, Erasmus ME, de Bock GH, Verschuuren EAM, Rácz E. Azathioprine to mycophenolate mofetil transition and risk of squamous cell carcinoma after lung transplantation. J Heart Lung Transplant. 2018 Jul;37(7):853-859.

Gao Y, Twigg AR, Hirose R, Roll GR, Nowacki AS, Maytin EV, Vidimos AT, Rajalingam R, Arron ST. Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant. JAMA Dermatol. 2019 Jan 23. doi: 10.1001/jamadermatol.2018.4983
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Laatst gewijzigd: 23 februari 2012