Popeye or pinnochio? The relationship between muscle mass and grip strength in an elderly population by measuring mass and testing grip strength.

geriatrics muscle mass grip Strength

Prof. dr. S.E.J.A. de Rooij
Dr. B.C. van Munster
F. van Raamt
Dr. P. van Duijvendijk

Type of project:
Stage Wetenschap / Researchproject, Stage Wetenschap / Researchproject of Stage Wetenschap / Researchproject

Nature of the research:
Prospective observational study

Fields of study:
surgery radiology geriatrics

Background / introduction
The quest for eternal life has been challenging the scientific world ever since it existed. Though we all want to become very old, no one wants to be old, or even worse, frail. Frailty is a state of increased vulnerability towards stressors in older individuals, leading to an increased risk of developing adverse health outcomes.1 Weight loss, decreased muscle strength, reduced physical activity, exhaustion, and reduced walking speed, are all symptoms of a physical definition of frailty.2 Physical decline not only is a potential risk factor for the occurrence of adverse events such as falls and postoperative complications3, it also puts elderly at risk for social isolation. On the positive side, physical frailty has a lot of potential anchors for possible treatment in the future. Currently, the decreased physical performance is both described as decline in muscle mass or muscle strength. The first is calculated on a Computer Tomography scans (CT) (L3 level, psoas major)4, the latter by measured with a dynamometer.5 For future research, it is essential to correlate these different measurement tools to each other. Therefore, this project aims to observe both grip strength and muscle mass in elderly in order to describe their relation.
Research question / problem definition
Is grip strength, tested with a dynamometer, related to muscle mass, measured on a CT-scan? Can we correlate objectively measurable symptoms to functional physical state of elderly?
You will prospectively include elderly patients attending the department of radiology for CT of the abdomen. Data will be collected on demographics, reason for CT, functionality and comorbidity. Muscle strength will be measured by handgrip measurement. Muscle mass will be calculated by the Hounsfield Unit Average Calcultation from CT abdomen. A database will be built in SPSS.
The second period of your internship will consist of analyzing and interpreting the collected data. Co-authorship in writing a paper is encouraged. If you are interested, please contact us to discuss the possibilities
Location of research: Gelre Hospitals, department of geriatrics, Apeldoorn and Department of Internal Medicin UMCG
1. Fried, L.P. et al. From bedside to bench: research agenda for frailty. Science Aging Knowledgde Environment. 2005
2. Makaray MA, Segev DL, Pronovost PJ, Sygin D, Bandeen-Roche K, Patel P, Takenga R, Fried LP. Frailty as a predictor of surgical outcomes in older patients. J Ann Coll Surg 2010; 210: 901-908
3. Tan KY, Kawamura YJ, Tokomitsu A, Tang T. Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Ann J Surg 2012; 204: 139-143
4. Joglekar, S., Asghar, A., Mott, S. L., Johnson, B. E., Button, A. M., Clark, E., & Mezhir, J. J. (2014). Sarcopenia is an independent predictor of complications following pancreatectomy for adenocarcinoma. Journal of surgical oncology, 111, 771-775.
5. Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, et al. (2006) Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. The journals of gerontology Series A, Biological sciences and medical sciences 61: 72–77.
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Laatst gewijzigd: 23 februari 2012