Projectenlijst per vakgebied



Hieronder ziet u een lijst van projecten behorende tot een bepaald vakgebied. Gebruik de bovenstaande keuzelijst om projecten van een ander vakgebied te tonen.

Het is ook mogelijk om te zoeken op trefwoord.

Klik op de titel van het project voor meer informatie.

 

Abnormal tissue repair and remodeling in COPD; from genomics to biological function

Researchers
Dr. C.A. Brandsma
prof. dr. W. Timens
dr. M. van den Berge

Keywords:
COPD eQTL Fibroblast

Airway epithelial-to-mesenchymal transition: Compartmentalized cyclic AMP signaling?

Researchers
prof. dr. M. Schmidt

Keywords:
epithelial-mesenchymal compartmentalization drug targeting

Application of Next-Generation Sequencing in managing hospital outbreaks with Multidrug Resistant Gram-Negative Bacteria

Researchers
Prof. dr. A.W. Friedrich

Keywords:
molecular biology molecular microbiology

Aquaglyceroporin-3 (AQP3) as an “elusive” drug target for cancer treatment: development of new approaches to study its structure and function

Researchers
Dr. A. Casini
dr. A. Kocer

Keywords:
cancer aquaporins biophysics

Assessing the potential of aneuploidy targeting drugs

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

Cardiomyopathies due to mutations in Heat Shock Protein

Researchers
prof. dr. H.H. Kampinga
Dr. B.J.J.M. Brundel

Keywords:
heat shock proteins cell biology cardiomyopathy

Caspase-1 inhibitors to fight neuroinflammation

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
crystallography Alzheimers Caspse 1

Cause and Effect: Genetic susceptibility to noxious particles and the influence of these factors on chromosomal stability

Researchers
dr. H.I. Heijink
dr. M. van den Berge
dr. A. Faiz

Keywords:
COPD smoking ageing lungs

Cellular and organismal ageing and (neuro)degeneration: effects of molecular chaperones

Researchers
prof. dr. H.H. Kampinga
dr. S. Carra

Keywords:
heat shock proteins molecular chaperones protein folding diseases chaperonopathies

Chaperoning DNA repair

Researchers
Dr. S. Bergink

Keywords:
DNA repair genome stability

Characterizing genes that convert aneuploid cells into aneuploid cancer cells

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

Chemical Correction of FVII Mutation

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
hemophilia factor VIII crystallography

Chemical correction of the R175C p53 missmutation

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
p53 missmutation chemical correction novel cancer drug

Chemotherapy-induced cellular senescence

Researchers
Dr. M. Demaria

Keywords:
chemotherapy Cellular senescence Skin cancer

COPZ1:COPgamma interaction as a target for the treatment of metastatic and dormant cancers in humans

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
cancer Structural biology Non-metastatic

Defining the molecular mechanisms for high-frequency transmission of the Staphylococcus aureus USA300 lineage

Researchers
Prof. dr. J.M. van Dijl
Prof. dr. A.W. Friedrich
dr. E. Tsompanidou
C. Glasner

Keywords:
molecular microbiology Staphylococcus aureus transmission

Development of new chemotherapeutic compounds targeted at histone acetyl transferases

Researchers
Dr. F.J. Dekker
Prof. dr. H.J. Haisma

Keywords:
cancer histone

Dissecting the role of cellular senescence in the pathogenesis of COPD

Researchers
Dr. C.A. Brandsma
dr. H.I. Heijink
Dr. M. Demaria
Dr. M. de Vries

Keywords:
COPD stem cells ageing

DNA damage and protein quality control (no place available in 2013/14)

Researchers
Dr. S. Bergink
Prof. dr. ir. E.A.A. Nollen

Keywords:
neurodegeneration DNA repair protein quality control

Eat more molecular! Modulating the gastrointestinal immune system to support health

Researchers
P. de Vos

Keywords:
immunology carbohydrates intestine

Elucidate DNA damage signaling pathway in experimental and human atrial fibrillation

Researchers
Dr. B.J.J.M. Brundel

Keywords:
Atrial fibrillation DNA damage

Endothelial-Mesenchymal Transition in Cardiovascular Disease

Researchers
dr. G. Krenning
dr. J.A.J. Moonen

Keywords:
microRNA epigenetics signal transduction

Epigenetic edeting

Researchers
D. Goubert

Keywords:
breast cancer epigenetics CRISP/Cas

Epigenetic editing towards directed gene silencing of oncogenes

Researchers
No researchers found

Keywords:
gene expression epigenetics gene regulation

Epigenetics of Endothelial Dysfunction

Researchers
dr. G. Krenning
Dr. M.C. Harmsen
M. Maleszewska

Keywords:
epigenetics Endothelial Cell Polycomb

Fibulin-5; a key player in elastogenesis and emphysema development in COPD?

Researchers
Dr. C.A. Brandsma
prof. dr. W. Timens
J.C. Wolters

Keywords:
COPD proteomics lung tissue

Fragment based drug discovery of antagonists of the Il17-Il17rec. interaction

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
crystallography interleukin small molecule

Functional characterization of genetic susceptibility variants of Celiac disease

Researchers
V. Kumar
dr. S. Withoff
prof. dr. C. Wijmenga

Keywords:
transcription factor celiac disease autoimmune disease EMSA ChIP assay

Genome instability and neurodegeneration

Researchers
prof. dr. H.H. Kampinga
Dr. S. Bergink

Keywords:
neurodegeneration DNA damage

Hemagglutinin targeting small molecules as next generation influenza drugs

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
influenza small molecule hemagglutinin

Identification and characterization of novel mTOR regulators

Researchers
prof. dr. K. Thedieck

Keywords:
proteomics Metabolic signaling systems biology

Identification of the gene regulatory processes underlying the pathophysiology of type 2 diabetes.

Researchers
dr. J.W. Jonker

Keywords:
gene regulation energy metabolism type 2 diabetes

IL-17A receptor inhibitors for the treatment of inflammation

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
inflammation Structural biology auto-immune

Illustrating the role of microbiome in human health

Researchers
Dr. J. Fu
Prof. M.H. Hofker
D.P.Y. Koonen

Keywords:
metabolism bioinformatics metagenomics

Imaging of Cancer Cell Death: pre-clinical development of new probes for quantification of caspase-3 activity and PS exposure

Researchers
prof. dr. S. de Jong
dr. H.H. Boersma
dr. A. Rybczynska
prof. dr. R.A. Dierckx
Prof. dr. P.H. Elsinga

Keywords:
pre-clinical imaging cancer cell apoptosis kinetic modeling

Inducing regeneration through manipulation of Wnt signaling

Researchers
dr. P.M. Weissert
Prof. dr. E.V. Berezikov

Keywords:
stem cells regeneration Wnt signaling

Investigating the role of lincRNAs in autoimmune diseases

Researchers
dr. S. Withoff
V. Kumar
prof. dr. C. Wijmenga

Keywords:
RNA celiac disease autoimmune disease

Investigating the role of miRNAs in autoimmune diseases

Researchers
dr. S. Withoff
V. Kumar
prof. dr. C. Wijmenga

Keywords:
microRNA miRNA celiac disease autoimmune disease non-coding RNA

Keeping inflammation under control: new insights in the NF-kB signaling pathway at the organismal level

Researchers
dr. A.J.A. van de Sluis

Keywords:
inflammation gene expression NF-kB signaling

Menin:MLL interactions as a target for the treatment of acute leukemia

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
leukemia Structural biology Drug design

microRNAs in Diabetic Retinopathy

Researchers
dr. G. Krenning
J.F. Friedrich

Keywords:
microRNA diabetes Endothelial Cell

Novel miRNA - target gene interactions in B cell lymphoma

Researchers
dr. A. van den Berg
dr. J.L. Kluiver

Keywords:
microRNA B cell lymphoma microRNA target genes

Optogenetic and chemogenetic approach to tackle neuronal cell death

Researchers
prof. dr. M. Schmidt
Asst. Prof. A. Dolga

Keywords:
mitochondria Optogenetics SK channels

Protein damage control in diseases of aging

Researchers
No researchers found

Keywords:
protein aggregation C. elegans Parkinson's disease Alzheimer's disease Huntington's disease

Regulation of aging and age-related disease by transcription factors, chromatin states, and the epigenome

Researchers
dr. C.G. Riedel

Keywords:
epigenetics transcriptional regulation aging

Reversal of cardiomyocyte remodeling in Atrial Fibrillation

Researchers
Dr. B.J.J.M. Brundel
drs. M. Wiersma

Keywords:
Atrial fibrillation

Small molecules for the cancer relevant protein protein interaction p53 mdm2

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
crystallography protein protein interaction small molecule inhibitor

Sorting membrane proteins: understanding the role of a novel dynamic protein-network in intracellular cargo transport and delivery

Researchers
dr. A.J.A. van de Sluis

Keywords:
cardiovascular disease cellular trafficking cholesterol homoestasis

Stem cells and oncogenesis in a novel model organism

Researchers
Prof. dr. E.V. Berezikov
dr. D. Olivieri

Keywords:
cancer stem cells DNA damage response

Telomeres, Genome Integrity, and Replicative Ageing

Researchers
Dr. M. Chang

Keywords:
ageing telomere genome integrity

The effect of O-glycosylation of Death Receptor 4 and 5 on TRAIL sensitivity

Researchers
prof. dr. W.J. Quax
I.A.M. van Roosmalen
MSc. D. Wilffert

Keywords:
O-glycosylation cancer cell apoptosis TRAIL Death Receptors

The Epac1 and Epac2 signalosome – unravelling molecular mechanisms underlying unwanted effects of β2-agonists with focus on biased signaling

Researchers
prof. dr. M. Schmidt

Keywords:
Biased agonism

The functionale relevance of microRNAs in COPD; their role in regulating pulmonary fibroblast function in COPD development

Researchers
Dr. C.A. Brandsma
prof. dr. W. Timens
dr. A. van den Berg

Keywords:
COPD miRNA

The role of aneuploidy in ageing

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

The role of noncoding RNAs in B cell lymphoma

Researchers
dr. A. van den Berg
dr. J.L. Kluiver

Keywords:
Long non-coding RNAs miRNAs Regulating networks

The role of Nrf2 in ovarian carcinogenesis

Researchers
prof. dr. M.G. Rots

Keywords:
carcinogenesis gene expression oxidative stress

The role of p53 in Atrial Fibrillation

Researchers
Dr. B.J.J.M. Brundel
drs. M. Wiersma

Keywords:

The role of phospholipid flippases in autophagy

Researchers
Dr. F. Kriegenburg
Prof. dr. F.M. Reggiori

Keywords:
Autophagy lipid flippases Ymr1

The role of the cargo during the induction of selective autophagy

Researchers
Prof. dr. F.M. Reggiori
dr. R. Gómez-Sánchez

Keywords:
Autophagy Yeast Cvt pathway

Unraveling disease mechanisms in Noordzeeziekte (progressive myoclonus epilepsy due to GOSR2 mutations)

Researchers
prof. dr. O.C.M. Sibon
prof. dr. M.A.J. de Koning-Tijssen
dr. T.J. de Koning
Dr. D.S. Verbeek
dr. A.J.A. van de Sluis

Keywords:
Noordzeeziekte basic research disease models

Unraveling the causative genes – and pathways - for autoimmune diseases

Researchers
V. Kumar
dr. S. Withoff
prof. dr. C. Wijmenga

Keywords:
pathway analysis celiac disease autoimmune disease gene enrichment T cell genes

Unraveling the genetic and biological pathways of spinocerebellar ataxia

Researchers
Dr. D.S. Verbeek

Keywords:
neurodegeneration exome sequencing human genetics

Unraveling the non-coding RNA network involved in IGF signaling

Researchers
dr. A. van den Berg
dr. J.L. Kluiver
dr. L. Visser

Keywords:
non-coding RNA B-cell lymphoma IGF signaling

back to toptop