List of projects by field of study



Below you see a list of researchprojects within a certain field of study. Please use the selectbox to view researchprojects of another field of research.

It  is also possible to search for keywords.

Click the title of a researchproject for more details.

 

A three-dimensional cell culture system for the study of intestinal epithelial integrity

Researchers
Dr. S.C.D. van IJzendoorn

Keywords:
intestinal integrity epithelial cells Advanced cell culture

Altered resistance of "diseased" liver cells to cell death

Researchers
prof.dr. A.J. Moshage

Keywords:
cell death cholestasis fibrosis

Aquaglyceroporin-3 (AQP3) as an “elusive” drug target for cancer treatment: development of new approaches to study its structure and function

Researchers
Dr. A. Casini
dr. A. Kocer

Keywords:
cancer aquaporins biophysics

Assessing the potential of aneuploidy targeting drugs

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

Cardiomyopathies due to mutations in Heat Shock Protein

Researchers
prof. dr. H.H. Kampinga
Dr. B.J.J.M. Brundel

Keywords:
heat shock proteins cell biology cardiomyopathy

Cause and Effect: Genetic susceptibility to noxious particles and the influence of these factors on chromosomal stability

Researchers
dr. H.I. Heijink
dr. M. van den Berge
dr. A. Faiz

Keywords:
COPD smoking ageing lungs

Cellular and organismal ageing and (neuro)degeneration: effects of molecular chaperones

Researchers
prof. dr. H.H. Kampinga
dr. S. Carra

Keywords:
heat shock proteins molecular chaperones protein folding diseases chaperonopathies

Chaperoning DNA repair

Researchers
Dr. S. Bergink

Keywords:
DNA repair genome stability

Characterizing genes that convert aneuploid cells into aneuploid cancer cells

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

Chemotherapy-induced cellular senescence

Researchers
Dr. M. Demaria

Keywords:
chemotherapy Cellular senescence Skin cancer

Dissecting the role of cofilin and phospholipase D1 interactions in actin cytoskeletal dynamics driven pathogen/host interactions and innate immune responses.

Researchers
prof. dr. M. Schmidt
dr. M.R. Groves

Keywords:
Innate immune response Actin dynamic small interfering molecules

DNA damage and protein quality control (no place available in 2013/14)

Researchers
Dr. S. Bergink
Prof. dr. ir. E.A.A. Nollen

Keywords:
neurodegeneration DNA repair protein quality control

Drosophila as model organism for neurodegeneration and aging

Researchers
prof. dr. O.C.M. Sibon

Keywords:
ageing neurodegenerative diseases Drosophila

Drosophila models to understand rare genetic disorders

Researchers
No researchers found

Keywords:
Drosophila neurodegeneration genetics

Dysfunctional crosstalk between epithelial cells and fibroblasts in COPD and the ageing lung

Researchers
Dr. C.A. Brandsma
dr. H.I. Heijink

Keywords:
COPD cigarette smoke ageing

Elucidate DNA damage signaling pathway in experimental and human atrial fibrillation

Researchers
Dr. B.J.J.M. Brundel

Keywords:
Atrial fibrillation DNA damage

From hibernation to the clinic: novel drugs that protect from cellular damage and organ injury

Researchers
Prof. dr. R.H. Henning
Dr. B.J.J.M. Brundel

Keywords:
heat shock proteins Hibernation hydrogen sulfide

Functional characterization of genetic susceptibility variants of Celiac disease

Researchers
V. Kumar
dr. S. Withoff
prof. dr. C. Wijmenga

Keywords:
transcription factor celiac disease autoimmune disease EMSA ChIP assay

Genome instability and neurodegeneration

Researchers
prof. dr. H.H. Kampinga
Dr. S. Bergink

Keywords:
neurodegeneration DNA damage

Hemagglutinin targeting small molecules as next generation influenza drugs

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
influenza small molecule hemagglutinin

How do tumor cells survive genomic instability?

Researchers
dr. M.A.T.M. van Vugt
Dr. R.S.N. Fehrmann

Keywords:
breast cancer genomic instability bio-informatics

How do tumors with a DNA repair defect survive their genomic instability?

Researchers
dr. M.A.T.M. van Vugt

Keywords:
cell cycle BRCA1 DNA repair

Hydrogen Sulfide in Biology and Disease

Researchers
dr. H.G.D. Leuvenink
Prof. dr. H. van Goor
Prof. dr. J.L. Hillebrands

Keywords:
hydrogen sulfide renal disease transplantatation

Identification and characterization of novel mTOR regulators

Researchers
prof. dr. K. Thedieck

Keywords:
proteomics Metabolic signaling systems biology

Identification of the gene regulatory processes underlying the pathophysiology of type 2 diabetes.

Researchers
dr. J.W. Jonker

Keywords:
gene regulation energy metabolism type 2 diabetes

Inducing regeneration through manipulation of Wnt signaling

Researchers
dr. P.M. Weissert
Prof. dr. E.V. Berezikov

Keywords:
stem cells regeneration Wnt signaling

Interactions between CNS and immune system in neurodegenerative diseases.

Researchers
P.F. Dijkers

Keywords:
Drosophila Alzheimer's disease Genetic screens

Involvement of the immune system in neurodegerative diseases

Researchers
P.F. Dijkers

Keywords:
immunology neurodegeneration

Keeping inflammation under control: new insights in the NF-kB signaling pathway at the organismal level

Researchers
dr. A.J.A. van de Sluis

Keywords:
inflammation gene expression NF-kB signaling

Liver syndecan-1 shedding and dyslipidaemia in renal diseases

Researchers
Dr. J. van den Born
S. Adepu

Keywords:
cardiovascular kidney triglyceride

Long non-coding RNA in liver disease

Researchers
dr. A.J.A. van de Sluis
Dr. J. Fu
Prof. M.H. Hofker

Keywords:
genomics molecular genetics cardiometabolic risk

Nanocarrier-mediated drug delivery into the brain

Researchers
I.M.S. Degors
dr. I.S. Zuhorn

Keywords:
drug delivery blood-brain barrier transcytosis

Novel miRNA - target gene interactions in B cell lymphoma

Researchers
dr. A. van den Berg
dr. J.L. Kluiver

Keywords:
microRNA B cell lymphoma microRNA target genes

Nuclear Envelope deformation in Ageing

Researchers
dr. L.M. Veenhoff

Keywords:
Ageing, Nuclear Envelope, Nuclear Pore Complex

Protein damage control in diseases of aging

Researchers
No researchers found

Keywords:
protein aggregation C. elegans Parkinson's disease Alzheimer's disease Huntington's disease

Regeneration of myelin in multiple sclerosis lesions

Researchers
prof.dr. D. Hoekstra

Keywords:
multiple sclerosis oligodendrocytes assembly of myelin membranes

Regulation of aging and age-related disease by transcription factors, chromatin states, and the epigenome

Researchers
dr. C.G. Riedel

Keywords:
epigenetics transcriptional regulation aging

Reversal of cardiomyocyte remodeling in Atrial Fibrillation

Researchers
Dr. B.J.J.M. Brundel
drs. M. Wiersma

Keywords:
Atrial fibrillation

Small molecules for the cancer relevant protein protein interaction p53 mdm2

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
crystallography protein protein interaction small molecule inhibitor

Sorting membrane proteins: understanding the role of a novel dynamic protein-network in intracellular cargo transport and delivery

Researchers
dr. A.J.A. van de Sluis

Keywords:
cardiovascular disease cellular trafficking cholesterol homoestasis

Stem cells and oncogenesis in a novel model organism

Researchers
Prof. dr. E.V. Berezikov
dr. D. Olivieri

Keywords:
cancer stem cells DNA damage response

Telomeres, Genome Integrity, and Replicative Ageing

Researchers
Dr. M. Chang

Keywords:
ageing telomere genome integrity

The effect of human cytomegalovirus-encoded viral chemokine receptors on renal fibrogenesis in renal transplantation

Researchers
Dr. J. van den Born
prof. dr. W.J. van Son

Keywords:
virus kidney transplantation fibrosis

The role of aneuploidy in ageing

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

The role of Nrf2 in ovarian carcinogenesis

Researchers
prof. dr. M.G. Rots

Keywords:
carcinogenesis gene expression oxidative stress

The role of p53 in Atrial Fibrillation

Researchers
Dr. B.J.J.M. Brundel
drs. M. Wiersma

Keywords:

The role of phospholipid flippases in autophagy

Researchers
Dr. F. Kriegenburg
Prof. dr. F.M. Reggiori

Keywords:
Autophagy lipid flippases Ymr1

The role of the cargo during the induction of selective autophagy

Researchers
Prof. dr. F.M. Reggiori
dr. R. Gómez-Sánchez

Keywords:
Autophagy Yeast Cvt pathway

Therapeutic blockade of lymphangiogenesis in renal diseases

Researchers
Dr. J. van den Born

Keywords:
inflammation fibrosis angiogenesis

Tissue repair in COPD: WNT you get it right?

Researchers
Dr. R. Gosens

Keywords:
COPD WNT tissue repair

Understanding the pathogenesis of microvillus inclusion disease

Researchers
Dr. S.C.D. van IJzendoorn

Keywords:
intestinal disease cellular architecture microvillus inclusion disease

Understanding the role of fibulin-1 in the ECM niche in Idiopathic Pulmonary Fibrosis

Researchers
dr. B.N. Melgert
J.K. Burgess
R.A. Bank

Keywords:
fibrosis extracellular matrix

Unraveling the genetic and biological pathways of spinocerebellar ataxia

Researchers
Dr. D.S. Verbeek

Keywords:
neurodegeneration exome sequencing human genetics

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