Projectenlijst per vakgebied



Hieronder ziet u een lijst van projecten behorende tot een bepaald vakgebied. Gebruik de bovenstaande keuzelijst om projecten van een ander vakgebied te tonen.

Het is ook mogelijk om te zoeken op trefwoord.

Klik op de titel van het project voor meer informatie.

 

A three-dimensional cell culture system for the study of intestinal epithelial integrity

Researchers
Dr. S.C.D. van IJzendoorn

Keywords:
intestinal integrity epithelial cells Advanced cell culture

Altered resistance of "diseased" liver cells to cell death

Researchers
prof.dr. A.J. Moshage

Keywords:
cell death cholestasis fibrosis

Aquaglyceroporin-3 (AQP3) as an “elusive” drug target for cancer treatment: development of new approaches to study its structure and function

Researchers
Dr. A. Casini
dr. A. Kocer

Keywords:
cancer aquaporins biophysics

Assessing the potential of aneuploidy targeting drugs

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

Cardiomyopathies due to mutations in Heat Shock Protein

Researchers
prof. dr. H.H. Kampinga
Dr. B.J.J.M. Brundel

Keywords:
heat shock proteins cell biology cardiomyopathy

Cause and Effect: Genetic susceptibility to noxious particles and the influence of these factors on chromosomal stability

Researchers
dr. H.I. Heijink
dr. M. van den Berge
dr. A. Faiz

Keywords:
COPD smoking ageing lungs

Cellular and organismal ageing and (neuro)degeneration: effects of molecular chaperones

Researchers
prof. dr. H.H. Kampinga
dr. S. Carra

Keywords:
heat shock proteins molecular chaperones protein folding diseases chaperonopathies

Chaperoning DNA repair

Researchers
Dr. S. Bergink

Keywords:
DNA repair genome stability

Characterizing genes that convert aneuploid cells into aneuploid cancer cells

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

Chemotherapy-induced cellular senescence

Researchers
Dr. M. Demaria

Keywords:
chemotherapy Cellular senescence Skin cancer

Dissecting the role of cofilin and phospholipase D1 interactions in actin cytoskeletal dynamics driven pathogen/host interactions and innate immune responses.

Researchers
prof. dr. M. Schmidt
dr. M.R. Groves

Keywords:
Innate immune response Actin dynamic small interfering molecules

DNA damage and protein quality control (no place available in 2013/14)

Researchers
Dr. S. Bergink
Prof. dr. ir. E.A.A. Nollen

Keywords:
neurodegeneration DNA repair protein quality control

Drosophila as model organism for neurodegeneration and aging

Researchers
prof. dr. O.C.M. Sibon

Keywords:
ageing neurodegenerative diseases Drosophila

Drosophila models to understand rare genetic disorders

Researchers
No researchers found

Keywords:
Drosophila neurodegeneration genetics

Dysfunctional crosstalk between epithelial cells and fibroblasts in COPD and the ageing lung

Researchers
Dr. C.A. Brandsma
dr. H.I. Heijink

Keywords:
COPD cigarette smoke ageing

Elucidate DNA damage signaling pathway in experimental and human atrial fibrillation

Researchers
Dr. B.J.J.M. Brundel

Keywords:
Atrial fibrillation DNA damage

From hibernation to the clinic: novel drugs that protect from cellular damage and organ injury

Researchers
Prof. dr. R.H. Henning
Dr. B.J.J.M. Brundel

Keywords:
heat shock proteins Hibernation hydrogen sulfide

Functional characterization of genetic susceptibility variants of Celiac disease

Researchers
V. Kumar
dr. S. Withoff
prof. dr. C. Wijmenga

Keywords:
transcription factor celiac disease autoimmune disease EMSA ChIP assay

Genome instability and neurodegeneration

Researchers
prof. dr. H.H. Kampinga
Dr. S. Bergink

Keywords:
neurodegeneration DNA damage

Hemagglutinin targeting small molecules as next generation influenza drugs

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
influenza small molecule hemagglutinin

How do tumor cells survive genomic instability?

Researchers
dr. M.A.T.M. van Vugt
Dr. R.S.N. Fehrmann

Keywords:
breast cancer genomic instability bio-informatics

How do tumors with a DNA repair defect survive their genomic instability?

Researchers
dr. M.A.T.M. van Vugt

Keywords:
cell cycle BRCA1 DNA repair

Hydrogen Sulfide in Biology and Disease

Researchers
dr. H.G.D. Leuvenink
Prof. dr. H. van Goor
Prof. dr. J.L. Hillebrands

Keywords:
hydrogen sulfide renal disease transplantatation

Identification and characterization of novel mTOR regulators

Researchers
prof. dr. K. Thedieck

Keywords:
proteomics Metabolic signaling systems biology

Identification of the gene regulatory processes underlying the pathophysiology of type 2 diabetes.

Researchers
dr. J.W. Jonker

Keywords:
gene regulation energy metabolism type 2 diabetes

Inducing regeneration through manipulation of Wnt signaling

Researchers
dr. P.M. Weissert
Prof. dr. E.V. Berezikov

Keywords:
stem cells regeneration Wnt signaling

Interactions between CNS and immune system in neurodegenerative diseases.

Researchers
P.F. Dijkers

Keywords:
Drosophila Alzheimer's disease Genetic screens

Involvement of the immune system in neurodegerative diseases

Researchers
P.F. Dijkers

Keywords:
immunology neurodegeneration

Keeping inflammation under control: new insights in the NF-kB signaling pathway at the organismal level

Researchers
dr. A.J.A. van de Sluis

Keywords:
inflammation gene expression NF-kB signaling

Liver syndecan-1 shedding and dyslipidaemia in renal diseases

Researchers
Dr. J. van den Born
S. Adepu

Keywords:
cardiovascular kidney triglyceride

Long non-coding RNA in liver disease

Researchers
dr. A.J.A. van de Sluis
Dr. J. Fu
Prof. M.H. Hofker

Keywords:
genomics molecular genetics cardiometabolic risk

Nanocarrier-mediated drug delivery into the brain

Researchers
I.M.S. Degors
dr. I.S. Zuhorn

Keywords:
drug delivery blood-brain barrier transcytosis

Novel miRNA - target gene interactions in B cell lymphoma

Researchers
dr. A. van den Berg
dr. J.L. Kluiver

Keywords:
microRNA B cell lymphoma microRNA target genes

Nuclear Envelope deformation in Ageing

Researchers
dr. L.M. Veenhoff

Keywords:
Ageing, Nuclear Envelope, Nuclear Pore Complex

Protein damage control in diseases of aging

Researchers
No researchers found

Keywords:
protein aggregation C. elegans Parkinson's disease Alzheimer's disease Huntington's disease

Regeneration of myelin in multiple sclerosis lesions

Researchers
prof.dr. D. Hoekstra

Keywords:
multiple sclerosis oligodendrocytes assembly of myelin membranes

Regulation of aging and age-related disease by transcription factors, chromatin states, and the epigenome

Researchers
dr. C.G. Riedel

Keywords:
epigenetics transcriptional regulation aging

Reversal of cardiomyocyte remodeling in Atrial Fibrillation

Researchers
Dr. B.J.J.M. Brundel
drs. M. Wiersma

Keywords:
Atrial fibrillation

Small molecules for the cancer relevant protein protein interaction p53 mdm2

Researchers
prof.dr. A.S.S. Doemling
dr. M.R. Groves

Keywords:
crystallography protein protein interaction small molecule inhibitor

Sorting membrane proteins: understanding the role of a novel dynamic protein-network in intracellular cargo transport and delivery

Researchers
dr. A.J.A. van de Sluis

Keywords:
cardiovascular disease cellular trafficking cholesterol homoestasis

Stem cells and oncogenesis in a novel model organism

Researchers
Prof. dr. E.V. Berezikov
dr. D. Olivieri

Keywords:
cancer stem cells DNA damage response

Telomeres, Genome Integrity, and Replicative Ageing

Researchers
Dr. M. Chang

Keywords:
ageing telomere genome integrity

The effect of human cytomegalovirus-encoded viral chemokine receptors on renal fibrogenesis in renal transplantation

Researchers
Dr. J. van den Born
prof. dr. W.J. van Son

Keywords:
virus kidney transplantation fibrosis

The role of aneuploidy in ageing

Researchers
No researchers found

Keywords:
Mouse models Aneuploidy Chromosomal instability

The role of Nrf2 in ovarian carcinogenesis

Researchers
prof. dr. M.G. Rots

Keywords:
carcinogenesis gene expression oxidative stress

The role of p53 in Atrial Fibrillation

Researchers
Dr. B.J.J.M. Brundel
drs. M. Wiersma

Keywords:

The role of phospholipid flippases in autophagy

Researchers
Dr. F. Kriegenburg
Prof. dr. F.M. Reggiori

Keywords:
Autophagy lipid flippases Ymr1

The role of the cargo during the induction of selective autophagy

Researchers
Prof. dr. F.M. Reggiori
dr. R. Gómez-Sánchez

Keywords:
Autophagy Yeast Cvt pathway

Therapeutic blockade of lymphangiogenesis in renal diseases

Researchers
Dr. J. van den Born

Keywords:
inflammation fibrosis angiogenesis

Tissue repair in COPD: WNT you get it right?

Researchers
Dr. R. Gosens

Keywords:
COPD WNT tissue repair

Understanding the pathogenesis of microvillus inclusion disease

Researchers
Dr. S.C.D. van IJzendoorn

Keywords:
intestinal disease cellular architecture microvillus inclusion disease

Understanding the role of fibulin-1 in the ECM niche in Idiopathic Pulmonary Fibrosis

Researchers
dr. B.N. Melgert
J.K. Burgess
R.A. Bank

Keywords:
fibrosis extracellular matrix

Unraveling the genetic and biological pathways of spinocerebellar ataxia

Researchers
Dr. D.S. Verbeek

Keywords:
neurodegeneration exome sequencing human genetics

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